YRC Public Data Repository - Protein Structure Prediction

Protein:	trm8
Organism:	Schizosaccharomyces pombe
Length:	273 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for trm8.

Description	E-value	Query Range	Subject Range
gi\|77961509, gi\|... - gi\|77961509\|ref\|ZP_00825345.1\| COG0220: Predicted S-adenosylmethionine-dependent methyltransferase [...	187.0	[0..9]	[270..3]
TRMB_PHOPR - tRNA (guanine-N(7)-)-methyltransferase OS=Photobacterium profundum GN=trmB PE=3 SV=1 TRMB_PHOPR - tRNA (guanine-N(7)-)-methyltransferase OS=Photobacterium profundum (strain SS9) GN=trmB PE=3 SV=1	186.0	[0..1]	[270..1]
gi\|77974451 - gi\|77974451\|ref\|ZP_00829991.1\| COG0220: Predicted S-adenosylmethionine-dependent methyltransferase [...	186.0	[0..9]	[270..16]
gi\|90412031, gi\|... - gi\|90412031\|ref\|ZP_01220038.1\| tRNA (guanine-N(7)-)-methyltransferase [Photobacterium profundum 3TCK...	186.0	[0..1]	[270..1]
gi\|90438578, gi\|... - gi\|90580276\|ref\|ZP_01236083.1\| tRNA (guanine-N(7)-)-methyltransferase [Vibrio angustum S14], gi\|9043...	186.0	[0..1]	[270..1]
gi\|186699683, gi... - gi\|186896657\|ref\|YP_001873769.1\| tRNA (guanine-N(7)-)-methyltransferase [Yersinia pseudotuberculosis... TRMB_YERP3 - tRNA (guanine-N(7)-)-methyltransferase OS=Yersinia pseudotuberculosis serotype O:1b (strain IP 31758...	185.0	[0..9]	[270..3]
gi\|77976486 - gi\|77976486\|ref\|ZP_00831972.1\| COG0220: Predicted S-adenosylmethionine-dependent methyltransferase [...	185.0	[0..9]	[270..16]
gi\|162354476, gi... - gi\|77633208\|ref\|ZP_00795352.1\| COG0220: Predicted S-adenosylmethionine-dependent methyltransferase [... gi\|165923261, gi... - gi\|165925061\|ref\|ZP_02220893.1\| tRNA (guanine-N(7)-)-methyltransferase [Yersinia pestis biovar Orien... gi\|165914683, gi... - gi\|165937209\|ref\|ZP_02225773.1\| tRNA (guanine-N(7)-)-methyltransferase [Yersinia pestis biovar Orien... gi\|166010280, gi... - gi\|166010280\|ref\|ZP_02231178.1\| tRNA (guanine-N(7)-)-methyltransferase [Yersinia pestis biovar Antiq... gi\|166212782, gi... - gi\|166212782\|ref\|ZP_02238817.1\| tRNA (guanine-N(7)-)-methyltransferase [Yersinia pestis biovar Antiq... gi\|167050525, gi... - gi\|167399817\|ref\|ZP_02305335.1\| tRNA (guanine-N(7)-)-methyltransferase [Yersinia pestis biovar Antiq... gi\|45443229, gi\|... - gi\|45443229\|ref\|NP_994768.1\| tRNA (guanine-N(7))-methyltransferase [Yersinia pestis biovar Microtus ... gi\|167421899, gi... - gi\|167421899\|ref\|ZP_02313652.1\| tRNA (guanine-N(7)-)-methyltransferase [Yersinia pestis biovar Orien... gi\|22127214, gi\|... - gi\|22127214\|ref\|NP_670637.1\| tRNA (guanine-N(7))-methyltransferase [Yersinia pestis KIM], gi\|2196028... gi\|167426711, gi... - gi\|167426711\|ref\|ZP_02318464.1\| tRNA (guanine-N(7)-)-methyltransferase [Yersinia pestis biovar Media... TRMB_YERPA - tRNA (guanine-N(7)-)-methyltransferase OS=Yersinia pestis bv. Antiqua (strain Antiqua) GN=trmB PE=3 ... gi\|15979020, gi\|... - gi\|218928122\|ref\|YP_002345997.1\| tRNA (guanine-N(7)-)-methyltransferase [Yersinia pestis CO92], gi\|1... gi\|229842568, gi... - gi\|229842568\|ref\|ZP_04462723.1\| tRNA (m7G46) methyltransferase, SAM-dependent [Yersinia pestis biova... TRMB_YERPN - tRNA (guanine-N(7)-)-methyltransferase OS=Yersinia pestis bv. Antiqua (strain Nepal516) GN=trmB PE=3... gi\|229840871, gi... - gi\|229840871\|ref\|ZP_04461030.1\| tRNA (m7G46) methyltransferase, SAM-dependent [Yersinia pestis biova... gi\|229837647, gi... - gi\|229837647\|ref\|ZP_04457809.1\| tRNA (m7G46) methyltransferase, SAM-dependent [Yersinia pestis Pesto... TRMB_YERPE - tRNA (guanine-N(7)-)-methyltransferase OS=Yersinia pestis GN=trmB PE=3 SV=1 TRMB_YERPP - tRNA (guanine-N(7)-)-methyltransferase OS=Yersinia pestis (strain Pestoides F) GN=trmB PE=3 SV=1 gi\|149290655, gi... - gi\|149367041\|ref\|ZP_01889074.1\| Putative methyltransferase [Yersinia pestis CA88-4125], gi\|149290655...	185.0	[0..9]	[270..3]
gi\|170023070, gi... - gi\|170023070\|ref\|YP_001719575.1\| tRNA (guanine-N(7)-)-methyltransferase [Yersinia pseudotuberculosis... TRMB_YERPS - tRNA (guanine-N(7)-)-methyltransferase OS=Yersinia pseudotuberculosis GN=trmB PE=3 SV=1 TRMB_YERPS - tRNA (guanine-N(7)-)-methyltransferase OS=Yersinia pseudotuberculosis serotype I (strain IP32953) GN...	185.0	[0..9]	[270..3]
gi\|89074116, gi\|... - gi\|89074116\|ref\|ZP_01160615.1\| tRNA (guanine-N(7)-)-methyltransferase [Photobacterium sp. SKA34], gi...	185.0	[0..1]	[270..1]

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Predicted Domain #1

Region A:
Residues: [1-273]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSATAKKSAA QLQREEEEAR KKLKRLSKQG GVEGRLPMKR LFRQRAHANV LSDHELEYPR  60
   61 SPSEMDWSPY YPDFDVESNK KVEIVDIGCG YGGLTVALGP QFPDTLVLGM EIRMQVSDYL 120
  121 KEKIQALRYR ADHEEPVPGG YKNISVLRMN CQKFLPNFFE KGQLSKMFFC FPDPHFKARK 180
  181 HKNRIITSTL ASEYAYFIRP HGTLYTITDV EELHVWMAQH LDAHPLFRRF TKEEEENDIC 240
  241 VTLMTNETEE GKKVARNGGK KFVACYERIP NPK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	32.0
Match:	1yzhA
Description:	Crystal Structure of the Conserved Hypothetical Protein, Methyltransferase from Streptococcus pneumoniae TIGR4
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
methyltransferase activity	4.15445027778357	bayes_pls_golite062009
N-methyltransferase activity	4.07806017452628	bayes_pls_golite062009
transferase activity, transferring one-carbon groups	4.07153733729662	bayes_pls_golite062009
protein methyltransferase activity	3.92746815303714	bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity	3.39429041855776	bayes_pls_golite062009
RNA methyltransferase activity	3.07428840534971	bayes_pls_golite062009
histone methyltransferase activity	2.99461585647365	bayes_pls_golite062009
tRNA methyltransferase activity	2.5931020126592	bayes_pls_golite062009
DNA-methyltransferase activity	2.43145108778901	bayes_pls_golite062009
arginine N-methyltransferase activity	2.41876112831625	bayes_pls_golite062009
protein-arginine N-methyltransferase activity	2.41876112831625	bayes_pls_golite062009
rRNA methyltransferase activity	2.29640050660273	bayes_pls_golite062009
transferase activity	2.22303238506686	bayes_pls_golite062009
histone-arginine N-methyltransferase activity	2.04296107639729	bayes_pls_golite062009
tRNA (cytosine-5-)-methyltransferase activity	1.88889414729709	bayes_pls_golite062009
tRNA (cytosine)-methyltransferase activity	1.88889414729709	bayes_pls_golite062009
protein-arginine omega-N monomethyltransferase activity	1.66871163498737	bayes_pls_golite062009
tRNA (adenine-N1-)-methyltransferase activity	1.53559006858264	bayes_pls_golite062009
tRNA (adenine)-methyltransferase activity	1.53559006858264	bayes_pls_golite062009
catalytic activity	1.25333584501255	bayes_pls_golite062009
histone methyltransferase activity (H4-R3 specific)	1.1103522853299	bayes_pls_golite062009
transcription regulator activity	0.914549843668268	bayes_pls_golite062009
protein-arginine omega-N asymmetric methyltransferase activity	0.89325812193225	bayes_pls_golite062009
DNA binding	0.86027591375666	bayes_pls_golite062009
rRNA (guanine) methyltransferase activity	0.720972789045101	bayes_pls_golite062009
site-specific DNA-methyltransferase (adenine-specific) activity	0.703178429468566	bayes_pls_golite062009
nucleic acid binding	0.616949327277483	bayes_pls_golite062009
rRNA (adenine) methyltransferase activity	0.533090627724779	bayes_pls_golite062009
rRNA (adenine-N6,N6-)-dimethyltransferase activity	0.455449410561251	bayes_pls_golite062009
RNA binding	0.417524996559564	bayes_pls_golite062009
binding	0.383237930789959	bayes_pls_golite062009
tRNA (guanine) methyltransferase activity	0.203168546434167	bayes_pls_golite062009
rRNA (uridine) methyltransferase activity	0.0858581024725429	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: