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Protein Overview: trt1

General Information:
Name(s) found: trt1 / SPBC29A3.14c [Sanger Pombe]
Description(s) found:
Found 20 descriptions.
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  • telomerase reverse transcriptase 1 protein Trt1 [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 988 amino acids

    Gene Ontology:
    Cellular Component: chromosome, telomeric region [ICLink to PubMed article]
    nucleus [IDALink to PubMed article]
    nuclear chromosome [ICLink to PubMed article]
    telomerase catalytic core complex [IDALink to PubMed article]
    Biological Process: RNA-dependent DNA replication [ICLink to PubMed article]
    telomere maintenance via telomerase [IMPLink to PubMed article]
    Molecular Function: telomeric template RNA reverse transcriptase activity [IMPLink to PubMed article]
    DNA binding [IEA]
    RNA binding [IPILink to PubMed article]
    protein binding [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTEHHTPKSR ILRFLENQYV YLCTLNDYVQ LVLRGSPASS YSNICERLRS DVQTSFSIFL  60
   61 HSTVVGFDSK PDEGVQFSSP KCSQSELIAN VVKQMFDESF ERRRNLLMKG FSMNHEDFRA 120
  121 MHVNGVQNDL VSTFPNYLIS ILESKNWQLL LEIIGSDAMH YLLSKGSIFE ALPNDNYLQI 180
  181 SGIPLFKNNV FEETVSKKRK RTIETSITQN KSARKEVSWN SISISRFSIF YRSSYKKFKQ 240
  241 DLYFNLHSIC DRNTVHMWLQ WIFPRQFGLI NAFQVKQLHK VIPLVSQSTV VPKRLLKVYP 300
  301 LIEQTAKRLH RISLSKVYNH YCPYIDTHDD EKILSYSLKP NQVFAFLRSI LVRVFPKLIW 360
  361 GNQRIFEIIL KDLETFLKLS RYESFSLHYL MSNIKISEIE WLVLGKRSNA KMCLSDFEKR 420
  421 KQIFAEFIYW LYNSFIIPIL QSFFYITESS DLRNRTVYFR KDIWKLLCRP FITSMKMEAF 480
  481 EKINENNVRM DTQKTTLPPA VIRLLPKKNT FRLITNLRKR FLIKMGSNKK MLVSTNQTLR 540
  541 PVASILKHLI NEESSGIPFN LEVYMKLLTF KKDLLKHRMF GRKKYFVRID IKSCYDRIKQ 600
  601 DLMFRIVKKK LKDPEFVIRK YATIHATSDR ATKNFVSEAF SYFDMVPFEK VVQLLSMKTS 660
  661 DTLFVDFVDY WTKSSSEIFK MLKEHLSGHI VKIGNSQYLQ KVGIPQGSIL SSFLCHFYME 720
  721 DLIDEYLSFT KKKGSVLLRV VDDFLFITVN KKDAKKFLNL SLRGFEKHNF STSLEKTVIN 780
  781 FENSNGIINN TFFNESKKRM PFFGFSVNMR SLDTLLACPK IDEALFNSTS VELTKHMGKS 840
  841 FFYKILRSSL ASFAQVFIDI THNSKFNSCC NIYRLGYSMC MRAQAYLKRM KDIFIPQRMF 900
  901 ITDLLNVIGR KIWKKLAEIL GYTSRRFLSS AEVKWLFCLG MRDGLKPSFK YHPCFEQLIY 960
  961 QFQSLTDLIK PLRPVLRQVL FLHRRIAD

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..187] PSI-BLAST 19.522879 Crystal Structure of the TEN domain of the Telomerase Reverse Transcriptase
    2 View Details [188..273] PSI-BLAST 10.0 Endonuclease domain of human LINE1 ORF2p
    3 View Details [274..363] FFAS03 1.4 No description for 2ijd1 was found.
    4 View Details [364..900] FFAS03 1.31 POLIOVIRUS 3D POLYMERASE
    5 View Details [901..988] FFAS03 0.968 The crystal structure of the monomeric reverse transcriptase from Moloney murine leukemia virus

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • DNA polymerase activity
    		•  5.39280130797076 bayes_pls_golite062009
  • DNA-directed DNA polymerase activity
    		•  5.37020615560876 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  4.29265204071625 bayes_pls_golite062009
  • DNA primase activity
    		•  3.72505743683034 bayes_pls_golite062009
  • binding
    		•  1.65023283997779 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.58132518850155 bayes_pls_golite062009
  • DNA binding
    		•  1.49092185389589 bayes_pls_golite062009
  • exonuclease activity
    		•  1.38951646742998 bayes_pls_golite062009
  • DNA-directed RNA polymerase activity
    		•  1.30261666633966 bayes_pls_golite062009
  • RNA polymerase activity
    		•  1.30261666633966 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.15351831059877 bayes_pls_golite062009
  • catalytic activity
    		•  0.985794797454925 bayes_pls_golite062009
  • transferase activity
    		•  0.562916058192021 bayes_pls_golite062009
  • 3'-5' exonuclease activity
    		•  0.427833022898625 bayes_pls_golite062009
  • protein binding
    		•  0.267061490746095 bayes_pls_golite062009
  • damaged DNA binding
    		•  0.251544222192079 bayes_pls_golite062009
  • chromatin binding
    		•  0.154937729400031 bayes_pls_golite062009
  • nuclease activity
    		•  0.126991239633667 bayes_pls_golite062009
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.77

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle