YRC Public Data Repository - Protein Structure Prediction

Protein:	trt1
Organism:	Schizosaccharomyces pombe
Length:	988 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for trt1.

Description	E-value	Query Range	Subject Range
gi\|7493461, gi\|2... - pir\|\|T03838 telomerase catalytic chain - fission yeast (Schizosaccharomyces pombe), gi\|2340169\|gb\|A...	653.0	[0..1]	[988..1]
gi\|38110208, gi\|... - gi\|39951949\|ref\|XP_363691.1\| hypothetical protein MGG_01617 [Magnaporthe grisea 70-15], gb\|EAA55966....	464.0	[0..14]	[945..55]
gi\|46108320, gi\|... - gi\|46108320\|ref\|XP_381218.1\| hypothetical protein FG01042.1 [Gibberella zeae PH-1], gi\|42545017\|gb\|E...	358.0	[0..12]	[922..31]
gi\|22324593 - gi\|22324593\|gb\|AAM95622.1\| telomerase reverse transcriptase [Moneuplotes crassus]	357.0	[0..25]	[923..32]
gi\|67526591, gi\|... - gi\|67526591\|ref\|XP_661357.1\| hypothetical protein AN3753.2 [Aspergillus nidulans FGSC A4], ref\|XP_40...	354.0	[0..14]	[920..53]
gi\|37654330 - gi\|37654330\|gb\|AAQ96270.1\| LRRGT00057 [Rattus norvegicus]	351.0	[0..186]	[962..1164]
gi\|90299156, gi\|... - gi\|90299156\|gb\|EAS28787.1\| hypothetical protein CIMG_07533 [Coccidioides immitis RS], gi\|119177095\|r...	334.0	[0..14]	[893..110]

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Predicted Domain #1

Region A:
Residues: [1-187]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTEHHTPKSR ILRFLENQYV YLCTLNDYVQ LVLRGSPASS YSNICERLRS DVQTSFSIFL  60
   61 HSTVVGFDSK PDEGVQFSSP KCSQSELIAN VVKQMFDESF ERRRNLLMKG FSMNHEDFRA 120
  121 MHVNGVQNDL VSTFPNYLIS ILESKNWQLL LEIIGSDAMH YLLSKGSIFE ALPNDNYLQI 180
  181 SGIPLFK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	19.522879
Match:	2b2aA
Description:	Crystal Structure of the TEN domain of the Telomerase Reverse Transcriptase
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [188-273]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NNVFEETVSK KRKRTIETSI TQNKSARKEV SWNSISISRF SIFYRSSYKK FKQDLYFNLH  60
   61 SICDRNTVHM WLQWIFPRQF GLINAF

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	10.0
Match:	1vybA
Description:	Endonuclease domain of human LINE1 ORF2p
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [274-363]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QVKQLHKVIP LVSQSTVVPK RLLKVYPLIE QTAKRLHRIS LSKVYNHYCP YIDTHDDEKI  60
   61 LSYSLKPNQV FAFLRSILVR VFPKLIWGNQ

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	1.4
Match:	2ijd1
Description:	No description for 2ijd1 was found.

Predicted Domain #4

Region A:
Residues: [364-900]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RIFEIILKDL ETFLKLSRYE SFSLHYLMSN IKISEIEWLV LGKRSNAKMC LSDFEKRKQI  60
   61 FAEFIYWLYN SFIIPILQSF FYITESSDLR NRTVYFRKDI WKLLCRPFIT SMKMEAFEKI 120
  121 NENNVRMDTQ KTTLPPAVIR LLPKKNTFRL ITNLRKRFLI KMGSNKKMLV STNQTLRPVA 180
  181 SILKHLINEE SSGIPFNLEV YMKLLTFKKD LLKHRMFGRK KYFVRIDIKS CYDRIKQDLM 240
  241 FRIVKKKLKD PEFVIRKYAT IHATSDRATK NFVSEAFSYF DMVPFEKVVQ LLSMKTSDTL 300
  301 FVDFVDYWTK SSSEIFKMLK EHLSGHIVKI GNSQYLQKVG IPQGSILSSF LCHFYMEDLI 360
  361 DEYLSFTKKK GSVLLRVVDD FLFITVNKKD AKKFLNLSLR GFEKHNFSTS LEKTVINFEN 420
  421 SNGIINNTFF NESKKRMPFF GFSVNMRSLD TLLACPKIDE ALFNSTSVEL TKHMGKSFFY 480
  481 KILRSSLASF AQVFIDITHN SKFNSCCNIY RLGYSMCMRA QAYLKRMKDI FIPQRMF

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	1.31
Match:	1rdrA
Description:	POLIOVIRUS 3D POLYMERASE
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
DNA polymerase activity	5.39280130797076	bayes_pls_golite062009
DNA-directed DNA polymerase activity	5.37020615560876	bayes_pls_golite062009
nucleotidyltransferase activity	4.29265204071625	bayes_pls_golite062009
DNA primase activity	3.72505743683034	bayes_pls_golite062009
binding	1.65023283997779	bayes_pls_golite062009
nucleic acid binding	1.58132518850155	bayes_pls_golite062009
DNA binding	1.49092185389589	bayes_pls_golite062009
exonuclease activity	1.38951646742998	bayes_pls_golite062009
DNA-directed RNA polymerase activity	1.30261666633966	bayes_pls_golite062009
RNA polymerase activity	1.30261666633966	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.15351831059877	bayes_pls_golite062009
catalytic activity	0.985794797454925	bayes_pls_golite062009
transferase activity	0.562916058192021	bayes_pls_golite062009
3'-5' exonuclease activity	0.427833022898625	bayes_pls_golite062009
protein binding	0.267061490746095	bayes_pls_golite062009
damaged DNA binding	0.251544222192079	bayes_pls_golite062009
chromatin binding	0.154937729400031	bayes_pls_golite062009
nuclease activity	0.126991239633667	bayes_pls_golite062009

Predicted Domain #5

Region A:
Residues: [901-988]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ITDLLNVIGR KIWKKLAEIL GYTSRRFLSS AEVKWLFCLG MRDGLKPSFK YHPCFEQLIY  60
   61 QFQSLTDLIK PLRPVLRQVL FLHRRIAD

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	0.968
Match:	1rw3A
Description:	The crystal structure of the monomeric reverse transcriptase from Moloney murine leukemia virus
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: