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Protein Overview: rga2

General Information:
Name(s) found: rga2 / SPAC26A3.09c [Sanger Pombe]
Description(s) found:
Found 18 descriptions.
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  • GTPase activating protein Rga2 [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 1275 amino acids

    Gene Ontology:
    Cellular Component: cell division site [IDALink to PubMed article]
    cell tip [IDALink to PubMed article]
    Biological Process: regulation of Rho GTPase activity [ISS]
    Molecular Function: Rho GTPase activator activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVKMDVVRTT GFFLRSEPTT CRITTFAYSA EIIYFHAETT FLFEKIMKEG NELEKYSKIE  60
   61 LNSEIWEDEE EEDNSGIVSQ NERLMKLVNK QREIIYELHK DLEKVKKDNT SLRMRLSKYE 120
  121 STDSFPSSQP SRANSPQSDS YSSPYEKGKL FPKISLKSSK DVPTASAHIS SSDHEKSSSV 180
  181 SLSALNNYNK TTDIKARSLD RLSDMTRPKL LLNTKRSHRS SEEPGASSPV TSPILKDSQK 240
  241 ERIQALRNKA IKTYSVSTES AERIDSIRSD NLSPLSLNTS SFRRPITKPT PFNSDSNISI 300
  301 DPKDNNSNKQ DHFAEIEDEL RQQFLDIKVG RANASSPRRK SISIVKPHGI SSPKHSTNNL 360
  361 SSKSGKFHSD FRVVSENVLL QARSETNSPI IENKEANNFL APTSNVPAYS TPARPTESPP 420
  421 PPPISSSSTT PRPDDKPSLP PRGLSEDNDS LSLQKTGSSD TRRSSFSTLK IPDSDICFTR 480
  481 RRSDSNRTWT VIDPHHSQSF DNDILAEIPT SKLDNSSQKS PGKLSSKGLL NSFSPISPFS 540
  541 KSKSHNHHPS SQVEKSTSNS KGSMLPLDTL YNNKLSFRLD ESLVRYLRFE LMKTSLASLS 600
  601 PDFDCIGLQF VVGVSASSHL ASQWKDEVWS FTRSIGECRS FATSFVLDIG APPFPTLDWF 660
  661 TNDSSVIQNE LLRRSVDTYF RYIFQTDLKL EQRIKLLEFL SSDTLREYLH DVFFLPPEHA 720
  721 QKEGVLLKYI ENSGLVSRYF YLKDNILYFA ENRNSPVLGT IHLKDAQVNR YNANLPIFSI 780
  781 IDPPHEFLTG ENYQSAFVIQ EKQTETRTGT ATVHVLLARD VEDQKSWLRA ILRQVPGSTS 840
  841 PLNASPFSVL SSDFPGSSRY RDQSSPIRFY GKADSRPVSQ EAILSQDISS SPSPVLPPSE 900
  901 NVASYADDSL VSNLTMSPKL RDSMEQVPLE NHREFEISDR VSELSFDSST GSVLEIADTR 960
  961 RNQDAPEKHV PVIEIQSSRP SLEKTDQSTP VELLIDSHSQ NSQNEEKRSR MKFWAFPHHK1020
 1021 AENYEQISDT NIPVIETNVM LSPSSTTSAE PLQKHIVRKS GIFGLPLNEA VNISTQFNDS1080
 1081 GLPIVVYRCI EYLESCRAEK EEGIYRLSGS ASTIKHLKEQ FNEGVDYDLL SSDEEFDVHV1140
 1141 IAGLLKLYLR NLPTNLLDTS MHKLFELLPN VPNDSAALGE LCDVISKLPP ENFALLDSLL1200
 1201 HHLRRIIAFE KVNKMNIRNV CIVFSPTLNI PSDIFMMLIL NYDHIFTDIS RQTNGAQNES1260
 1261 DSDVSDDNGE DNEFF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..130] deduced N/A No confident structure predictions are available.
    2 View Details [131..347] deduced N/A No confident structure predictions are available.
    3 View Details [348..450] MSA 3.231995 View MSA. No confident structure predictions are available.
    4 View Details [451..561] MSA 4.213992 View MSA. No confident structure predictions are available.
    5 View Details [562..642] deduced N/A No confident structure predictions are available.
    6 View Details [643..721] PSI-BLAST 6.30103 crystal structure of CISK-PX domain with sulfates
    7 View Details [722..839] PSI-BLAST 31.154902 Triglycine variant of the Grp1 Pleckstrin Homology Domain unliganded
    8 View Details [840..1275] PSI-BLAST 80.522879 Crystal Structure of the Human Beta2-Chimaerin

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6
    Term Confidence Notes
  • binding
    		•  2.39207685184342 bayes_pls_golite062009
  • protein binding
    		•  1.80677432725077 bayes_pls_golite062009
    7 No functions predicted.
    8
    Term Confidence Notes
  • Rho GTPase activator activity
    		•  4.45527136122296 bayes_pls_golite062009
  • Rac GTPase activator activity
    		•  4.36872878750284 bayes_pls_golite062009
  • GTPase regulator activity
    		•  2.61511682702035 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  2.59032629780818 bayes_pls_golite062009
  • binding
    		•  2.15139804299723 bayes_pls_golite062009
  • guanyl-nucleotide exchange factor activity
    		•  1.96768465804738 bayes_pls_golite062009
  • enzyme regulator activity
    		•  1.87657402052119 bayes_pls_golite062009
  • small GTPase regulator activity
    		•  1.85037053674911 bayes_pls_golite062009
  • protein binding
    		•  1.29100556128076 bayes_pls_golite062009
  • diacylglycerol binding
    		•  1.02792245495259 bayes_pls_golite062009
  • Ras GTPase activator activity
    		•  0.982302027631241 bayes_pls_golite062009
  • Rho guanyl-nucleotide exchange factor activity
    		•  0.890065668535699 bayes_pls_golite062009
  • Ras guanyl-nucleotide exchange factor activity
    		•  0.874385217290396 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.690843185161327 bayes_pls_golite062009
  • GTPase activator activity
    		•  0.635863123494771 bayes_pls_golite062009
  • kinase activity
    		•  0.411929190066223 bayes_pls_golite062009
  • enzyme activator activity
    		•  0.223298136783465 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.164035505126366 bayes_pls_golite062009
  • Rho GTPase binding
    		•  0.150587174126097 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle