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Protein Overview: smc6

General Information:
Name(s) found: smc6 / SPCC5E4.06 [Sanger Pombe]
Description(s) found:
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  • pir||T41457 dna repair protein rad18 - fission yeast (Schizosaccharomyces pombe) [NCBI NR]
  • gi|3859084|emb|CAA21961.1| Smc5-6 complex SMC subunit Smc6 [Schizosaccharomyces pombe] [NCBI NR]
  • gi|19075406|ref|NP_587906.1| Smc5-6 complex SMC subunit Smc6 [Schizosaccharomyces pombe 972h-] [NCBI NR]
  • gi|1709997|sp|P53692.1|SMC6_SCHPO RecName: Full=Structural maintenance of chromosomes protein 6; AltName: Full=DNA repair protein rad18 [NCBI NR]
  • gi|1150622|emb|CAA56900.1| rad18 [Schizosaccharomyces pombe] [NCBI NR]
  • Smc5-6 complex SMC subunit Smc6 [Sanger Pombe]
  • Structural maintenance of chromosomes protein 6 OS=Schizosaccharomyces pombe GN=smc6 PE=1 SV=1 [Swiss-Prot]
  • (P53692) DNA repair protein rad18 [Swiss-Prot]
  • DNA REPAIR PROTEIN; SIMILAR TO S. CEREVISIAE RHC18: P53692; [pompepVF.fasta]
  • DNA REPAIR PROTEIN RAD18: P53692; [pompepV13]
  • DNA repair protein rad18 [pompep4896]
  • |rad18||DNA repair protein [pompepnew.fasta]
  • |rad18|smc6|SMC family|Schizosaccharomyces pombe|chr 3|||Manual [pombe041504.fasta]
  • |smc6|rad18|Smc5-6 complex SMC subunit|Schizosaccharomyces pombe|chr 3|||Manual [pompep2242005.fasta]
  • dna repair protein rad18 [Schizosaccharomyces pombe]gi|1150622|emb|CAA56900.1| rad18 [Schizosaccharomyces pombe]gi|3859084|emb|CAA21961.1| rad18 [Schizosaccharomyces pombe]gi|1709997|sp|P53692|RA18_SCHPO DNA repair protein rad18gi|7490474|pir||T41457 [nrdb_11152004_Chlamydomonas]
  • |smc6|rad18|Smc5-6 complex SMC subunit Smc6|Schizosaccharomyces pombe|chr 3|||Manual [SGD_S-Pombe_na_10-23-2009_con_reversed.fasta]
  • hypothetical protein SPCC5E4.06 [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta]
  • SPCC5E4.06 [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • Structural maintenance of chromosome 6 (DNA repair protein rad18) [nr-271106-contam.fasta]
  • rad18 [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • Structural maintenance of chromosomes protein 6 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=smc6 PE=1 SV=1 [uniprot_sprot.fasta.20160308]
    • Organism: Schizosaccharomyces pombe
    Length: 1140 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ICLink to PubMed article][IDALink to PubMed article]
    Smc5-Smc6 complex [IDALink to PubMed article]
    Biological Process: DNA repair [IMPLink to PubMed article]
    replication fork protection [ICLink to PubMed article]
    double-strand break repair via homologous recombination [TASLink to PubMed article]
    response to DNA damage stimulus [IMPLink to PubMed article]
    Molecular Function: ATP binding [IEA]
    protein binding [IPILink to PubMed article]
    protein heterodimerization activity [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTTELTNVSL EEAITEKTSE NRRKRDSDVL QTEEVDLSNV KRIRASRNQD NRPERQSRLQ  60
   61 RSSSLIEQVR GNEDGENDVL NQTRETNSNF DNRVGVIECI HLVNFMCHDS LKINFGPRIN 120
  121 FVIGHNGSGK SAILTGLTIC LGAKASNTNR APNMKSLVKQ GKNYARISVT ISNRGFEAYQ 180
  181 PEIYGKSITI ERTIRREGSS EYRLRSFNGT VISTKRDELD NICDHMGLQI DNPMNILTQD 240
  241 TARQFLGNSS PKEKYQLFMK GIQLKQLEEN YSLIEQSLIN TKNVLGNKKT GVSYLAKKEE 300
  301 EYKLLWEQSR ETENLHNLLE QKKGEMVWAQ VVEVEKELLL AEKEFQHAEV KLSEAKENLE 360
  361 SIVTNQSDID GKISSKEEVI GRAKGETDTT KSKFEDIVKT FDGYRSEMND VDIQKRDIQN 420
  421 SINAAKSCLD VYREQLNTER ARENNLGGSQ IEKRANESNN LQREIADLSE QIVELESKRN 480
  481 DLHSALLEMG GNLTSLLTKK DSIANKISDQ SEHLKVLEDV QRDKVSAFGK NMPQLLKLIT 540
  541 RETRFQHPPK GPMGKYMTVK EQKWHLIIER ILGNVINGFI VRSHHDQLIL KELMRQSNCH 600
  601 ATVVVGKYDP FDYSSGEPDS QYPTVLKIIK FDDDEVLHTL INHLGIEKML LIEDRREAEA 660
  661 YMKRGIANVT QCYALDPRNR GYGFRIVSTQ RSSGISKVTP WNRPPRIGFS SSTSIEAEKK 720
  721 ILDDLKKQYN FASNQLNEAK IEQAKFKRDE QLLVEKIEGI KKRILLKRRE VNSLESQELS 780
  781 VLDTEKIQTL ERRISETEKE LESYAGQLQD AKNEEHRIRD NQRPVIEEIR IYREKIQTET 840
  841 QRLSSLQTEL SRLRDEKRNS EVDIERHRQT VESCTNILRE KEAKKVQCAQ VVADYTAKAN 900
  901 TRCERVPVQL SPAELDNEIE RLQMQIAEWR NRTGVSVEQA AEDYLNAKEK HDQAKVLVAR 960
  961 LTQLLQALEE TLRRRNEMWT KFRKLITLRT KELFELYLSQ RNFTGKLVIK HQEEFLEPRV1020
 1021 YPANRNLATA HNRHEKSKVS VQGLSGGEKS FATICMLLSI WEAMSCPLRC LDEFDVFMDA1080
 1081 VNRLVSIKMM VDSAKDSSDK QFIFITPQDM GQIGLDKDVV VFRLSDPVVS SSALPPSTAP1140
 1141

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..94] deduced N/A No confident structure predictions are available.
    2 View Details [95..248] PSI-BLAST 9.39794 Sc Smc1hd:Scc1-C complex, ATPgS
    3 View Details [249..632] PSI-BLAST 14.522879 Heavy meromyosin subfragment
    4 View Details [633..713] deduced N/A No confident structure predictions are available.
    5 View Details [714..967] FFAS03 3.13 Tropomyosin
    6 View Details [968..1140] PSI-BLAST 4.69897 No description for 2pzeA was found.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle