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Protein Overview: pyp2

General Information:
Name(s) found: pyp2 / SPAC19D5.01 [Sanger Pombe]
Description(s) found:
Found 19 descriptions.
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  • tyrosine phosphatase Pyp2 [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 711 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed article]
    cytosol [IDALink to PubMed article]
    Biological Process: protein amino acid dephosphorylation [IGILink to PubMed article]
    negative regulation of meiosis [IMPLink to PubMed article]
    stress-activated MAPK cascade [IGILink to PubMed article]
    Molecular Function: protein binding [IPILink to PubMed article]
    protein tyrosine phosphatase activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLHLLSKDEF NSTLKSFEEQ TESVSWIIDL RLHSKYAVSH IKNAINVSLP TALLRRPSFD  60
   61 IGKVFACIKC NVKVSLDEIN AIFLYDSSMA GMNRIYDLVQ KFRRGGYSKK IYLLSNGFEA 120
  121 FASSHPDAIV STEMVKESVP YKIDINENCK LDILHLSDPS AVSTPISPDY SFPLRVPINI 180
  181 PPPLCTPSVV SDTFSEFASH AEYPGFSGLT PFSIHSPTAS SVRSCQSIYG SPLSPPNSAF 240
  241 QAEMPYFPIS PAISCASSCP STPDEQKNFF IVGNAPQQTP ARPSLRSVPS YPSSNNQRRP 300
  301 SASRVRSFSN YVKSSNVVNP SLSQASLEII PRKSMKRDSN AQNDGTSTMT SKLKPSVGLS 360
  361 NTRDAPKPGG LRRANKPCFN KETKGSIFSK ENKGPFTCNP WGAKKVSPPP CEVLADLNTA 420
  421 SIFYKFKRLE EMEMTRSLAF NDSKSDWCCL ASSRSTSISR KNRYTDIVPY DKTRVRLAVP 480
  481 KGCSDYINAS HIDVGNKKYI ACQAPKPGTL LDFWEMVWHN SGTNGVIVML TNLYEAGSEK 540
  541 CSQYWPDNKD HALCLEGGLR ISVQKYETFE DLKVNTHLFR LDKPNGPPKY IHHFWVHTWF 600
  601 DKTHPDIESI TGIIRCIDKV PNDGPMFVHC SAGVGRTGTF IAVDQILQVP KNILPKTTNL 660
  661 EDSKDFIFNC VNSLRSQRMK MVQNFEQFKF LYDVVDYLNS GVNQASKPLM T

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..105] PSI-BLAST 32.221849 Erk2 binding domain of Mapk phosphatase mkp-3
    2 View Details [106..329] PSI-BLAST 12.045757 No description for 2v5yA was found.
    3 View Details [330..711] PSI-BLAST 87.0 Crystal structure of human tyrosine phosphatase SHP-1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphoprotein phosphatase activity
    		•  4.79074052803751 bayes_pls_golite062009
  • phosphatase activity
    		•  4.46276380920308 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  4.26891308022499 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  3.37977783690618 bayes_pls_golite062009
  • protein tyrosine phosphatase activity
    		•  2.84204105189999 bayes_pls_golite062009
  • transferase activity
    		•  2.02756030435235 bayes_pls_golite062009
  • binding
    		•  1.72957395505299 bayes_pls_golite062009
  • protein binding
    		•  1.56606332199727 bayes_pls_golite062009
  • catalytic activity
    		•  0.687308230067573 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle