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Protein Overview: SPBC11C11.10

General Information:
Name(s) found: SPBC11C11.10 [Sanger Pombe]
Description(s) found:
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  • pir||T39326 pseudouridine synthase - fission yeast (Schizosaccharomyces pombe) [NCBI NR]
  • gi|3560201|emb|CAA20692.1| tRNA pseudouridine synthase [Schizosaccharomyces pombe] [NCBI NR]
  • gi|24638138|sp|O59721.2|PUS4_SCHPO RecName: Full=Probable tRNA pseudouridine synthase 4; AltName: Full=tRNA pseudouridine 55 synthase; Short=Psi55 synthase; AltName: Full=tRNA-uridine isomerase 4; AltName: Full=tRNA pseudouridylate synthase 4 [NCBI NR]
  • gi|19113192|ref|NP_596400.1| pseudouridine synthase [Schizosaccharomyces pombe] [NCBI NR]
  • pseudouridine synthase [Sanger Pombe]
  • Probable tRNA pseudouridine synthase 4 OS=Schizosaccharomyces pombe GN=SPBC11C11.10 PE=1 SV=2 [Swiss-Prot]
  • PUTATIVE PSEUDOURIDINE SYNTHASE PUTATIVE PSEUDOURIDYLATE SYNTHASE; SIMIALR TO S. CEREVISIAE PUS4: O59721; [pompepVF.fasta]
  • PUTATIVE PSEUDOURIDINE SYNTHASE PUTATIVE PSEUDOURIDYLATE SYNTHASE: O59721; [pompepV13]
  • Probable pseudouridylate synthase 4 (EC 4.2.1.70) (Pseudouridine synthase 4) (tRNA pseudouridine 55 synthase) (Psi55 synthase) [pompep4896]
  • ||SPBC3B8.13c|putative pseudouridine synthase [pompepnew.fasta]
  • ||SPBC3B8.13c|pseudouridine synthase (predicted)|Schizosaccharomyces pombe|chr 2|||Manual [pombe041504.fasta]
  • putative pseudouridine synthase [Schizosaccharomyces pombe]gi|3560201|emb|CAA20692.1| SPBC11C11.10 [Schizosaccharomyces pombe]gi|24638138|sp|O59721|PUS4_SCHPO Probable pseudouridylate synthase 4 (Pseudouridine synthase 4) (tRNA pseudouridine 55 synthase [nrdb_11152004_Chlamydomonas]
  • ||SPBC3B8.13c|pseudouridine synthase|Schizosaccharomyces pombe|chr 2|||Manual [pompep2242005.fasta]
  • (O59721) Probable pseudouridylate synthase 4 (EC 4.2.1.70) (Pseudouridine synthase 4) (tRNA pseudouridine 55 synthase) (Psi55 synthase) [pompep4896_normal_reversed]
  • ||SPBC3B8.13c|tRNA pseudouridine synthase|Schizosaccharomyces pombe|chr 2|||Manual [SGD_S-Pombe_na_10-23-2009_con_reversed.fasta]
  • Probable tRNA pseudouridine synthase 4 (tRNA pseudouridine 55 synthase) (Psi55 synthase) (tRNA-uridine isomerase 4) (tRNA pseudouridylate synthase 4) [nr-271106-contam.fasta]
  • SPBC11C11.10 [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • hypothetical protein SPBC11C11.10 [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta]
  • ||SPBC3B8.13c|tRNA pseudouridine synthase |Schizosaccharomyces pombe|chr 2|||Manual [Other_S_Pombe_12-15-2011_reversed.fasta]
  • Probable tRNA pseudouridine synthase 4 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPBC11C11.10 PE=1 SV=2 [uniprot_sprot.fasta.20160308]
    • Organism: Schizosaccharomyces pombe
    Length: 407 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article][ISSLink to PubMed article]
    mitochondrion [ISSLink to PubMed article]
    Biological Process: tRNA pseudouridine synthesis [IC]
    Molecular Function: RNA binding [IEA]
    pseudouridine synthase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTVTNTYNPT LFFTRVVFQR ITKFTAKANE ENEILFYALF VADLCLDMKG GLIAINKPSG  60
   61 RTSAQCLNEL KKIISNSELA QYFRPAPPHP NDRNRRRRKS NRLPDIKIGH GGTLDPLASG 120
  121 VLVVGLGTGT KQLSSLLSCM KTYRATALFG CSTDTYDSAG KIIKIAVHIP TKEEILSGLD 180
  181 AFRGDISQLP PLYSALHIQG KRLYEYAREG IPLPESIKAR SMHCEELILK DFIPKEEHTY 240
  241 TDPDEFASKE AIESEELLRP IEGGAERHDL LAKTEQDINP QDGDEKINAK SPTTNSVTDV 300
  301 AKDQTVTNPK KRKFEVTDLA RGSRPAIGPI AVLDMTVSSG FYVRSLIHDL GRQVNSEAHM 360
  361 VDLVRLKQGS FALDDENCFD FSEFSAPGWE EKLAAAFKID LKGDETS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..288] PSI-BLAST 54.39794 Crystal Structure of tRNA Pseudouridine Synthase TruB and Its RNA Complex: RNA-protein Recognition Through a Combination of Rigid Docking and Induced Fit
    2 View Details [289..407] FFAS03 5.92 Pseudouridine synthase II TruB, C-terminal domain; Pseudouridine synthase II TruB

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • pseudouridine synthase activity
    		•  5.19957135839682 bayes_pls_golite062009
  • intramolecular transferase activity
    		•  3.78688422405974 bayes_pls_golite062009
  • isomerase activity
    		•  2.91720316078381 bayes_pls_golite062009
  • catalytic activity
    		•  2.02180970970004 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.21173188039059 bayes_pls_golite062009
  • DNA binding
    		•  0.950713703876672 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.909704702595901 bayes_pls_golite062009
  • binding
    		•  0.730744558777463 bayes_pls_golite062009
  • RNA binding
    		•  0.706879359688019 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.72

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle