Protein Overview: ade1

General Information:
Name(s) found:	ade1 / SPBC405.01 [Sanger Pombe]
Description(s) found: SHOW ONLY BEST	pir\|\|S00652 phosphoribosylamine-glycine ligase (EC 6.3.4.13) - fission yeast (Schizosaccharomyces pombe) [NCBI NR] gi\|4904\|emb\|CAA29820.1\| unnamed protein product [Schizosaccharomyces pombe] [NCBI NR] gi\|2832882\|emb\|CAA16823.1\| phosphoribosylamine-glycine ligase [Schizosaccharomyces pombe] [NCBI NR] gi\|19113096\|ref\|NP_596304.1\| phosphoribosylamine-glycine ligase [Schizosaccharomyces pombe] [NCBI NR] gi\|131618\|sp\|P20772.1\|PUR2_SCHPO RecName: Full=Bifunctional purine biosynthetic protein ADE1; Includes: RecName: Full=Phosphoribosylamine--glycine ligase; AltName: Full=Glycinamide ribonucleotide synthetase; Short=GARS; AltName: Full=Phosphoribosylglycina [NCBI NR] phosphoribosylamine-glycine ligase [Sanger Pombe] Bifunctional purine biosynthetic protein ADE1 OS=Schizosaccharomyces pombe GN=ade1 PE=2 SV=1 [Swiss-Prot] BIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADE1 - INCLUDES:PHOSPHORIBOSYLAMINE--GLYCINE LIGASE PHOSPHORIBOSYLAMINE--GLYCINE LIGASE: P20772;Q9UUM5; [pompepVF.fasta] BIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADE1 -INCLUDES:PHOSPHORIBOSYLAMINE--GLYCINE LIGASE PHOSPHORIBOSYLAMINE--GLYCINE LIGASE: P20772;Q9UUM5; [pompepV13] Bifunctional purine biosynthetic protein ADE1 [Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (GARS) (Glycinamide ribonucleotide synthetase) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) ( [pompep4896] \|ade1\|min4, SPBC4C3.02c\|phosphoribosylamine-glycine ligase (PMID 3502942) [pompepnew.fasta] \|ade1\|min4, SPBC4C3.02c\|phosphoribosylamine-glycine ligase (PMID 3502942)\|Schizosaccharomyces pombe\|chr 2\|\|\|Manual [pombe041504.fasta] \|ade1\|min4, SPBC4C3.02c\|phosphoribosylamine-glycine ligase \|Schizosaccharomyces pombe\|chr 2\|\|\|Manual [pompep2242005.fasta] bifunctional purine biosynthetic protein ade1-includes:phosphoribosylamine--glycine ligase [Schizosaccharomyces pombe]gi\|4904\|emb\|CAA29820.1\| unnamed protein product [Schizosaccharomyces pombe]gi\|2832882\|emb\|CAA16823.1\| ade1 [Schizosaccharomyces pombe] [nrdb_11152004_Chlamydomonas] (P20772) Bifunctional purine biosynthetic protein ADE1 [Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (GARS) (Glycinamide ribonucleotide synthetase) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6 [pompep4896_normal_reversed] \|ade1\|min4, SPBC4C3.02c\|phosphoribosylamine-glycine ligase\|Schizosaccharomyces pombe\|chr 2\|\|\|Manual [SGD_S-Pombe_na_10-23-2009_con_reversed.fasta] unnamed protein product [Schizosaccharomyces pombe] [nr-271106-contam.fasta] Bifunctional purine biosynthetic protein ADE1 [Includes: Phosphoribosylamine--glycine ligase (GARS) (Glycinamide ribonucleotide synthetase) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (AIRS) (Phosphoribosyl-amino [nr-271106-contam.fasta] SPBC405.01 [Schizosaccharomyces pombe] [nr-271106-contam.fasta] hypothetical protein SPBC405.01 [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta] Bifunctional purine biosynthetic protein ADE1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=ade1 PE=3 SV=1 [uniprot_sprot.fasta.20160308]
Organism:	Schizosaccharomyces pombe
Length:	788 amino acids
Gene Ontology:
Cellular Component:	cytosol [IDA]
Biological Process:	'de novo' IMP biosynthetic process [IMP] purine base biosynthetic process [IEA]
Molecular Function:	ATP binding [IEA] phosphoribosylamine-glycine ligase activity [IMP] manganese ion binding [IEA] phosphoribosylformylglycinamidine cyclo-ligase activity [IMP]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEPIIALLIG NGGREHTIAW KLCESPLISK VYVAPGNGGT ASNGAESKME NVNIGVCDFE  60
   61 QLVKFALDKD VNLVIPGPEL PLVEGIEGHF RRVGIPCFGP SALAARMEGS KVFSKDFMHR 120
  121 NNIPTAVYKS FSNYDHAKSF LDTCTFDVVI KADGLAAGKG VIIPKTKKEA FEALESIMLN 180
  181 EEFGSAGKNV VIEELLEGEE LSILTFSDGY TCRSLPPAQD HKRAFDGDKG PNTGGMGCYA 240
  241 PTPVASPKLL ETVQSTIIQP TIDGMRHEGY PLVGILFTGL MLTPSGPRVL EYNVRFGDPE 300
  301 TQAVLPLLES DLAEIILACV NHRLDAIDIV ISRKFSCAVV CVAGGYPGPY NKGDIITFDA 360
  361 LKDKNTRIFH AGTSIRDGNV VTNGGRVLAV EATGDSVEAA VRLAYEGVKT VHFDKMFYRK 420
  421 DIAHHALNPK RKTREILTYE NSGVSVDNGN EFVQRIKDLV KSTRRPGADA DIGGFGGIFD 480
  481 LKQAGWNDPL LVSATDGVGS KLLIALSLNK HDTVGIDLVA MNVNDLVVQG AEPLIFLDYF 540
  541 ATGSLDLKVS TSFVEGVVKG CKQAGCALVG GETSEMPGLY HDGHYDANGT SVGAVSRDDI 600
  601 LPKPESFSKG DILLGLASDG VHSNGYSLVR KIVEYSDLEY TSVCPWDKNV RLGDSLLIPT 660
  661 RIYVKPLLHV IRKNIVKGMA HITGGGLVEN VPRMLPSHLN AIIDVDTWEV PEVFKWLKDA 720
  721 GNVPISDMAR TFNMGIGMVV AVASEDAEET MKELTSVGET VYRIGQLVDK ESSSERCHLV 780
  781 NLNKWETF

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..432]	PSI-BLAST	93.522879	No description for 2qk4A was found.
2	View Details	[433..788]	PSI-BLAST	83.69897	Aminoimidazole ribonucleotide synthetase (PurM) N-terminal domain; Aminoimidazole ribonucleotide synthetase (PurM) C-terminal domain

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.97

Protein Overview: ade1

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: