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Protein Overview: SPCC794.07

General Information:
Name(s) found: SPCC794.07 [Sanger Pombe]
Description(s) found:
Found 20 descriptions.
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  • dihydrolipoamide S-acetyltransferase E2 [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 483 amino acids

    Gene Ontology:
    Cellular Component: mitochondrial pyruvate dehydrogenase complex [ISSLink to PubMed article]
    mitochondrion [IDALink to PubMed article]
    Biological Process: acetyl-CoA biosynthetic process from pyruvate [ISSLink to PubMed article]
    Molecular Function: lipoic acid binding [IEA]
    dihydrolipoyllysine-residue acetyltransferase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLSANMLRRM HHGVAVTRML LVSNGKVQVK KSALYPVMAK LARTYATKNY PAHTVINMPA  60
   61 LSPTMTTGNI GAFQKKIGDK IEPGDVLCEI ETDKAQIDFE QQDEGYLAKI LIETGTKDVP 120
  121 VGKPLAVTVE NEGDVAAMAD FTIEDSSAKE PSAKSGEEKS APSSEKQSKE TSSPSNVSGE 180
  181 ERGDRVFASP LARKLAEEKD LDLSQIRGSG PNGRIIKVDI ENFKPVVAPK PSNEAAAKAT 240
  241 TPAASAADAA APGDYEDLPL SNMRKIIASR LAESKNMNPH YYVTVSVNME KIIRLRAALN 300
  301 AMADGRYKLS VNDLVIKATT AALRQVPEVN AAWMGDFIRQ YKNVDISMAV ATPSGLITPV 360
  361 IRNTHALGLA EISTLAKDYG QRARNNKLKP EEYQGGTFTI SNLGMFPVDQ FTAIINPPQA 420
  421 CILAVGTTVD TVVPDSTSEK GFKVAPIMKC TLSSDHRVVD GAMAARFTTA LKKILENPLE 480
  481 IML

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..243] PSI-BLAST 23.69897 The crystal structure of dihydrolipoamide dehydrogenase and dihydrolipoamide dehydrogenase-binding protein (didomain) subcomplex of human pyruvate dehydrogenase complex.
    2 View Details [244..483] PSI-BLAST 84.522879 Dihydrolipoamide succinyltransferase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • S-succinyltransferase activity
    		•  10.0778678835755 bayes_pls_golite062009
  • dihydrolipoyllysine-residue succinyltransferase activity
    		•  10.0778678835755 bayes_pls_golite062009
  • dihydrolipoyllysine-residue acetyltransferase activity
    		•  9.65061123545754 bayes_pls_golite062009
  • dihydrolipoamide S-acyltransferase activity
    		•  9.64995677986911 bayes_pls_golite062009
  • S-acetyltransferase activity
    		•  9.49696044977584 bayes_pls_golite062009
  • S-acyltransferase activity
    		•  8.45313874919036 bayes_pls_golite062009
  • pyruvate dehydrogenase activity
    		•  8.17557182322815 bayes_pls_golite062009
  • transferase activity, transferring acyl groups other than amino-acyl groups
    		•  6.86215901871647 bayes_pls_golite062009
  • acyltransferase activity
    		•  6.83977352892719 bayes_pls_golite062009
  • succinyltransferase activity
    		•  6.58826720904067 bayes_pls_golite062009
  • pyruvate dehydrogenase (acetyl-transferring) activity
    		•  6.40483178382327 bayes_pls_golite062009
  • acetyltransferase activity
    		•  6.08159176722072 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
    		•  5.93985773477717 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  4.60481199262496 bayes_pls_golite062009
  • alpha-ketoacid dehydrogenase activity
    		•  4.42757758312016 bayes_pls_golite062009
  • carnitine O-acyltransferase activity
    		•  2.87366177129153 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors
    		•  2.54513901872655 bayes_pls_golite062009
  • catalytic activity
    		•  1.51562638409295 bayes_pls_golite062009
  • O-acyltransferase activity
    		•  1.33852311685118 bayes_pls_golite062009
  • O-palmitoyltransferase activity
    		•  1.22729402619659 bayes_pls_golite062009
  • carnitine O-palmitoyltransferase activity
    		•  1.22729402619659 bayes_pls_golite062009
  • transferase activity
    		•  1.08341671157927 bayes_pls_golite062009
  • carnitine O-acetyltransferase activity
    		•  1.00868366840715 bayes_pls_golite062009
  • binding
    		•  0.801074244553007 bayes_pls_golite062009
  • O-acetyltransferase activity
    		•  0.54660034926676 bayes_pls_golite062009
  • protein binding
    		•  0.00454070917775817 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.88

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle