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Protein Overview: gap1

General Information:
Name(s) found: gap1 / SPBC646.12c [Sanger Pombe]
Description(s) found:
Found 21 descriptions.
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  • GTPase activating protein Gap1 [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 766 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytosol [IDALink to PubMed article]
    Biological Process: regulation of small GTPase mediated signal transduction [IEA]
    regulation of catalytic activity [ICLink to PubMed article]
    Ras protein signal transduction [ICLink to PubMed article]
    regulation of conjugation with cellular fusion by signal transduction [IMPLink to PubMed article]
    Molecular Function: Ras GTPase activator activity [IGILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTKRHSGTLS SSVLPQTNRL SLLRNRESTS VLYTIDLDME SDVEDAFFHL DRELHDLKQQ  60
   61 ISSQSKQNFV LERDVRYLDS KIALLIQNRM AQEEQHEFAK RLNDNYNAVK GSFPDDRKLQ 120
  121 LYGALFFLLQ SEPAYIASLV RRVKLFNMDA LLQIVMFNIY GNQYESREEH LLLSLFQMVL 180
  181 TTEFEATSDV LSLLRANTPV SRMLTTYTRR GPGQAYLRSI LYQCINDVAI HPDLQLDIHP 240
  241 LSVYRYLVNT GQLSPSEDDN LLTNEEVSEF PAVKNAIQER SAQLLLLTKR FLDAVLNSID 300
  301 EIPYGIRWVC KLIRNLTNRL FPSISDSTIC SLIGGFFFLR FVNPAIISPQ TSMLLDSCPS 360
  361 DNVRKTLATI AKIIQSVANG TSSTKTHLDV SFQPMLKEYE EKVHNLLRKL GNVGDFFEAL 420
  421 ELDQYIALSK KSLALEMTVN EIYLTHEIIL ENLDNLYDPD SHVHLILQEL GEPCKSVPQE 480
  481 DNCLVTLPLY NRWDSSIPDL KQNLKVTRED ILYVDAKTLF IQLLRLLPSG HPATRVPLDL 540
  541 PLIADSVSSL KSMSLMKKGI RAIELLDELS TLRLVDKENR YEPLTSEVEK EFIDLDALYE 600
  601 RIRAERDALQ DVHRAICDHN EYLQTQLQIY GSYLNNARSQ IKPSHSDSKG FSRGVGVVGI 660
  661 KPKNIKSSNT VKLSSQQLKK ESVLLNCTIP EFNVSNTYFT FSSPSTDNFV IAVYQRGHSK 720
  721 VLVEVCICLD DVLQRRYASN PVVDLGFLTF EANKLYHLFE QLFLRK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..106] PSI-BLAST 10.0 No description for 2uzpA was found.
    2 View Details [107..494] PSI-BLAST 67.0 GAP related domain of neurofibromin
    3 View Details [495..668] Pfam 35.327902 No description for PF03836.6 was found. No confident structure predictions are available.
    4 View Details [669..766] PSI-BLAST 33.0 Solution structure of the carboxyl-terminal RGC domain in human IQGAP1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • GTPase regulator activity
    		•  5.23789256375467 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  5.21562004568462 bayes_pls_golite062009
  • small GTPase regulator activity
    		•  4.91645234075732 bayes_pls_golite062009
  • GTPase activator activity
    		•  4.81440293338491 bayes_pls_golite062009
  • Ras GTPase activator activity
    		•  4.76400460221691 bayes_pls_golite062009
  • Rho GTPase activator activity
    		•  4.58620967349979 bayes_pls_golite062009
  • enzyme regulator activity
    		•  4.5322075775333 bayes_pls_golite062009
  • enzyme activator activity
    		•  4.29367232260052 bayes_pls_golite062009
  • Rac GTPase activator activity
    		•  3.7534755276462 bayes_pls_golite062009
  • binding
    		•  2.26769740280417 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.7749599892233 bayes_pls_golite062009
  • protein binding
    		•  1.21496582666968 bayes_pls_golite062009
  • actin binding
    		•  1.13416719679068 bayes_pls_golite062009
  • microfilament motor activity
    		•  1.03365614225436 bayes_pls_golite062009
  • actin filament binding
    		•  0.839166288425262 bayes_pls_golite062009
  • GTPase binding
    		•  0.54882559587114 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.534597007915358 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.400842733744238 bayes_pls_golite062009
  • small GTPase binding
    		•  0.36738560339155 bayes_pls_golite062009
  • DNA binding
    		•  0.313042678225127 bayes_pls_golite062009
    3 No functions predicted.
    4
    Term Confidence Notes
  • GTPase regulator activity
    		•  3.48313315541019 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  3.46216378778416 bayes_pls_golite062009
  • enzyme regulator activity
    		•  2.73117303901364 bayes_pls_golite062009
  • binding
    		•  2.64484246147413 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.78839270261062 bayes_pls_golite062009
  • actin binding
    		•  1.74809436294937 bayes_pls_golite062009
  • small GTPase regulator activity
    		•  1.52776228366828 bayes_pls_golite062009
  • protein binding
    		•  1.37785152807615 bayes_pls_golite062009
  • Ras GTPase activator activity
    		•  1.32591250158464 bayes_pls_golite062009
  • GTPase activator activity
    		•  0.945543525650563 bayes_pls_golite062009
  • small GTPase binding
    		•  0.78616895231719 bayes_pls_golite062009
  • GTPase binding
    		•  0.76727022636058 bayes_pls_golite062009
  • enzyme activator activity
    		•  0.514378360493585 bayes_pls_golite062009
  • enzyme binding
    		•  0.44096806806257 bayes_pls_golite062009
  • Ras GTPase binding
    		•  0.245740027562592 bayes_pls_golite062009
  • calmodulin binding
    		•  0.0745132195983638 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.44

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle