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Protein Overview: prp22

General Information:
Name(s) found: prp22 / SPAC10F6.02c [Sanger Pombe]
Description(s) found:
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  • pir||T37496 probable pre-mRNA splicing factor ATP-dependent RNA helicase - fission yeast (Schizosaccharomyces pombe) [NCBI NR]
  • gi|3913431|sp|O42643.1|PRP22_SCHPO RecName: Full=Pre-mRNA-splicing factor ATP-dependent RNA helicase prp22 [NCBI NR]
  • gi|2661607|emb|CAA15715.1| ATP-dependent RNA helicase Prp22 [Schizosaccharomyces pombe] [NCBI NR]
  • gi|19114165|ref|NP_593253.1| ATP-dependent RNA helicase Prp22 [Schizosaccharomyces pombe 972h-] [NCBI NR]
  • ATP-dependent RNA helicase Prp22 [Sanger Pombe]
  • Pre-mRNA-splicing factor ATP-dependent RNA helicase prp22 OS=Schizosaccharomyces pombe GN=prp22 PE=2 SV=1 [Swiss-Prot]
  • (O42643) Putative pre-mRNA-splicing factor ATP-dependent RNA helicase C10F6.02c (EC 3.6.1.-) [Swiss-Prot]
  • PUTATIVE PRE-MRNA SPLICING FACTOR; ATP-DEPENDENT RNA HELICASE; SIMILAR TO S. CEREVISIAE PRP22: O42643; [pompepVF.fasta]
  • Putative pre-mRNA splicing factor ATP-dependent RNA helicase C10F6.02c [pompep4896]
  • |prp22||pre-mRNA splicing factor [pompepnew.fasta]
  • |prp22||ATP-dependent|Schizosaccharomyces pombe|chr 1|||Manual [pombe041504.fasta]
  • putative pre-mRNA splicing factor ATP-dependent RNA helicase [Schizosaccharomyces pombe]gi|2661607|emb|CAA15715.1| SPAC10F6.02c [Schizosaccharomyces pombe]gi|3913431|sp|O42643|DHX8_SCHPO Putative pre-mRNA splicing factor ATP-dependent RNA helicase C10F6 [nrdb_11152004_Chlamydomonas]
  • (O42643) Putative pre-mRNA splicing factor ATP-dependent RNA helicase C10F6.02c [pompep4896_normal_reversed]
  • |prp22||ATP-dependent RNA helicase Prp22|Schizosaccharomyces pombe|chr 1|||Manual [SGD_S-Pombe_na_10-23-2009_con_reversed.fasta]
  • Putative pre-mRNA-splicing factor ATP-dependent RNA helicase C10F6.02c [nr-271106-contam.fasta]
  • SPAC10F6.02c [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • hypothetical protein SPAC10F6.02c [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta]
  • ATP-dependent RNA helicase Prp22 [Schizosaccharomyces pombe 972h-] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • Pre-mRNA-splicing factor ATP-dependent RNA helicase prp22 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=prp22 PE=1 SV=1 [uniprot_sprot.fasta.20160308]
    • Organism: Schizosaccharomyces pombe
    Length: 1168 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    spliceosomal complex [ISSLink to PubMed article]
    Biological Process: RNA splicing, via transesterification reactions [ISSLink to PubMed article]
    spliceosome disassembly [ISSLink to PubMed article]
    Molecular Function: ATP binding [IEA]
    RNA binding [IEA]
    ATP-dependent RNA helicase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDDLKELEYL SLVSKVASEI RNHTGIDDNT LAEFIINLHD QSKNYDEFKN NVLSCGGEFT  60
   61 DSFLQNISRL IKEIKPKDDI PTDNVNNGSN SVNGASHDLD SKDVDKQHQR KMFPGLSIPN 120
  121 STNNLRDRPA LMDNAMDELE ELSTLAKTRR NDRDSRRDER HYLNGIRERR ERSISPSFSH 180
  181 HSRTSISGQS HSSRSSRGPL LNAPTLYGIY SGVVSGIKDF GAFVTLDGFR KRTDGLVHIS 240
  241 NIQLNGRLDH PSEAVSYGQP VFVKVIRIDE SAKRISLSMK EVNQVTGEDL NPDQVSRSTK 300
  301 KGSGANAIPL SAQNSEIGHV NPLETFTSNG RKRLTSPEIW ELQQLAASGA ISATDIPELN 360
  361 DGFNTNNAAE INPEDDEDVE IELREEEPGF LAGQTKVSLK LSPIKVVKAP DGSLSRAAMQ 420
  421 GQILANDRRE IRQKEAKLKS EQEMEKQDLS LSWQDTMSNP QDRKFAQDVR DSAARQLTSE 480
  481 TPSWRQATRN ANISYGKRTT LSMKEQREGL PVFKLRKQFL EAVSKNQILV LLGETGSGKT 540
  541 TQITQYLAEE GYTSDSKMIG CTQPRRVAAM SVAKRVAEEV GCRVGEEVGY TIRFEDKTSR 600
  601 MTQIKYMTDG MLQRECLVDP LLSKYSVIIL DEAHERTVAT DVLFGLLKGT VLKRPDLKLI 660
  661 VTSATLDAER FSSYFYKCPI FTIPGRSYPV EIMYTKQPEA DYLDAALMTV MQIHLSEGPG 720
  721 DILVFLTGQE EIDTSCEILY ERSKMLGDSI PELVILPVYS ALPSEIQSRI FEPAPPGGRK 780
  781 VVIATNIAET SLTIDGIYYV VDPGFVKQSC FDPKLGMDSL IVTPISQAQA RQRSGRAGRT 840
  841 GPGKCYRLYT ESAYRNEMLP SPIPEIQRQN LSHTILMLKA MGINDLLNFD FMDPPPAQTM 900
  901 IAALQNLYAL SALDDEGLLT PLGRKMADFP MEPQLSKVLI TSVELGCSEE MLSIIAMLSV 960
  961 PNIWSRPREK QQEADRQRAQ FANPESDHLT LLNVYTTWKM NRCSDNWCYE HYIQARGMRR1020
 1021 AEDVRKQLIR LMDRYRHPVV SCGRKRELIL RALCSGYFTN VAKRDSHEGC YKTIVENAPV1080
 1081 YMHPSGVLFG KAAEWVIYHE LIQTSKEYMH TVSTVNPKWL VEVAPTFFKF ANANQVSKTK1140
 1141 KNLKVLPLYN RFEKPDEWRI SKQRKGGR

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..294] PSI-BLAST 15.09691 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3; Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domains 1 and 4; Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 6; Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domains 2 and 5
    2 View Details [295..389] deduced N/A No confident structure predictions are available.
    3 View Details [390..473] PSI-BLAST 4.522879 Crystal structure of the UvsW helicase from Bacteriophage T4
    4 View Details [474..869] PSI-BLAST 51.522879 Initiation factor 4a
    5 View Details [870..962] PSI-BLAST 12.39794 Nucleotide excision repair enzyme UvrB
    6 View Details [963..1091] deduced N/A Confident ab initio structure predictions are available.
    7 View Details [1092..1168] MSA 1.238997 View MSA. Confident ab initio structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle