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Protein Overview: chk1

General Information:
Name(s) found: chk1 / SPCC1259.13 [Sanger Pombe]
Description(s) found:
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  • gi|544017|sp|P34208.2|CHK1_SCHPO RecName: Full=Serine/threonine-protein kinase chk1; AltName: Full=Checkpoint kinase 1 [NCBI NR]
  • pir||S33597 protein kinase chk1 (EC 2.7.1.-) - fission yeast (Schizosaccharomyces pombe) [NCBI NR]
  • gi|4049546|emb|CAA22551.1| Chk1 protein kinase [Schizosaccharomyces pombe] [NCBI NR]
  • gi|311176|gb|AAA79758.1| protein kinase [Schizosaccharomyces pombe] [NCBI NR]
  • gi|19075570|ref|NP_588070.1| Chk1 protein kinase [Schizosaccharomyces pombe] [NCBI NR]
  • gi|1051231|gb|AAA80539.1| protein kinase [NCBI NR]
  • Chk1 protein kinase [Sanger Pombe]
  • Serine/threonine-protein kinase chk1 OS=Schizosaccharomyces pombe GN=chk1 PE=1 SV=2 [Swiss-Prot]
  • PROTEIN KINASE; DNA DAMAGE CHECKPOINT PROTEIN; SIMILAR TO S. CEREVISIAE CHK1: P34208; [pompepVF.fasta]
  • PROTEIN KINASE CHK1; DNA DAMAGE CHECKPOINT: P34208; [pompepV13]
  • Serine/threonine-protein kinase chk1 (EC 2.7.1.-) (Checkpoint kinase 1) [pompep4896]
  • |chk1|rad27|serine/threonine protein kinase [pompepnew.fasta]
  • Serine/threonine-protein kinase chk1 (EC 2.7.1.37) (Checkpoint kinase 1) [4896.FASTAC]
  • |chk1|rad27|serine/threonine protein kinase|Schizosaccharomyces pombe|chr 3|||Manual [pombe041504.fasta]
  • protein kinase chk1 [Schizosaccharomyces pombe]gi|4049546|emb|CAA22551.1| chk1 [Schizosaccharomyces pombe]gi|544017|sp|P34208|CHK1_SCHPO Serine/threonine-protein kinase chk1 (Checkpoint kinase 1)gi|539076|pir||S33597 protein kinase chk1 (EC 2.7.1.-) - [nrdb_11152004_Chlamydomonas]
  • |chk1|rad27|chk1 protein kinase|Schizosaccharomyces pombe|chr 3|||Manual [pompep2242005.fasta]
  • (P34208) Serine/threonine-protein kinase chk1 (EC 2.7.1.-) (Checkpoint kinase 1) [pompep4896_normal_reversed]
  • |chk1|rad27|Chk1 protein kinase|Schizosaccharomyces pombe|chr 3|||Manual [SGD_S-Pombe_na_10-23-2009_con_reversed.fasta]
  • protein kinase [nr-271106-contam.fasta]
  • Serine/threonine-protein kinase chk1 (Checkpoint kinase 1) [nr-271106-contam.fasta]
  • SPCC1259.13 [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • hypothetical protein SPCC1259.13 [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta]
  • Serine/threonine-protein kinase chk1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=chk1 PE=1 SV=2 [uniprot_sprot.fasta.20160308]
    • Organism: Schizosaccharomyces pombe
    Length: 496 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article][NASLink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    cytosol [IDALink to PubMed article]
    nucleoplasm [TASLink to PubMed article]
    Biological Process: DNA damage checkpoint [IGILink to PubMed article]
    protein amino acid phosphorylation [IDALink to PubMed article]
    regulation of mitotic cell cycle [NAS]
    Molecular Function: ATP binding [ISSLink to PubMed article]
    protein binding [IPILink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed article]
    protein serine/threonine kinase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAQKLDNFPY HIGREIGTGA FASVRLCYDD NAKIYAVKFV NKKHATSCMN AGVWARRMAS  60
   61 EIQLHKLCNG HKNIIHFYNT AENPQWRWVV LEFAQGGDLF DKIEPDVGID EDVAQFYFAQ 120
  121 LMEGISFMHS KGVAHRDLKP ENILLDYNGN LKISDFGFAS LFSYKGKSRL LNSPVGSPPY 180
  181 AAPEITQQYD GSKVDVWSCG IILFALLLGN TPWDEAISNT GDYLLYKKQC ERPSYHPWNL 240
  241 LSPGAYSIIT GMLRSDPFKR YSVKHVVQHP WLTSSTPFRT KNGNCADPVA LASRLMLKLR 300
  301 IDLDKPRLAS SRASQNDSGF SMTQPAFKKN DQKELDRVEV YGALSQPVQL NKNIDVTEIL 360
  361 EKDPSLSQFC ENEGFIKRLA KKAKNFYEIC PPERLTRFYS RASRETIIDH LYDSLRLLAI 420
  421 SVTMKYVRNQ TILYVNLHDK RKCLLQGVIE LTNLGHNLEL INFIKRNGDP LEWRKFFKNV 480
  481 VSSIGKPIVL TDVSQN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run ste13 No Comments Unpublished Data

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..306] PSI-BLAST 70.221849 Catalytic and ubiqutin-associated domains of MARK2/PAR-1: Wild type
    2 View Details [307..496] PSI-BLAST 16.221849 No description for 2ehbD was found.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle