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Protein Overview: dome-PA

General Information:
Name(s) found: dome-PA / FBpp0074525 [FlyBase]
Description(s) found:
Found 27 descriptions.
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  • The gene domeless is referred to in FlyBase by the symbol Dmel\dome (CG14226, FBgn0043903). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:19570090..19577549. It has the cytological map location 18D13-18E1. There is experimental evidence that it has the molecular function</span>: transmembrane receptor activity. There is experimental evidence that it is involved in the biological process</span>: blastoderm segmentation; morphogenesis of an epithelium; hindgut morphogenesis; border follicle cell migration; JAK-STAT cascade; open tracheal system development. 43 alleles are reported. The phenotypes of these alleles are annotated with 17 unique terms, many of which group under: organ system; spiracle; embryonic segment; integumentary specialisation; female germline cyst; proventriculus; embryonic abdomen; embryonic/larval tracheal system; follicle cell; embryonic hindgut; embryonic abdominal segment 4; embryonic tracheal system; external compound sense organ; adult segment. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1282 amino acids

    Gene Ontology:
    Cellular Component: apicolateral plasma membrane [IDA]
    plasma membrane [ISS][NAS]
    apical plasma membrane [TAS]
    Biological Process: immune response [TAS]
    morphogenesis of an epithelium [IMP]
    protein amino acid dephosphorylation [NAS]
    blastoderm segmentation [IMP][NAS]
    border follicle cell migration [IMP]
    hindgut morphogenesis [IMP]
    epithelial cell fate determination, open tracheal system [TAS]
    JAK-STAT cascade [IGI][NAS][TAS]
    open tracheal system development [IMP][NAS]
    Molecular Function: transmembrane receptor activity [IGI][ISS][TAS]
    protein tyrosine phosphatase activity [NAS]
    cytokine binding [NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVAQEQLVLL LMLLAGCRGG ANAILDPGWV IPSKVEQLIG GDFNLSCTLN EDYFNGKSAE  60
   61 DCPVEKLYFT GGGRVYRDSK HIRILNNTTI LFSDTNAVEQ ENDYHCMCDE YVINKSKVYV 120
  121 GTRPLLVRDF NCLDYDFQFM VCNFTQPPNT VITKYNISYN TNNDWRYSNT LDCNFDSAPV 180
  181 VTCNLTDDNY KRFSETFYFR LSISNALGHE TQPITINHFE RLVPARPGQN LTLLNRTESS 240
  241 VCLSWEMPRR SNYNRGLVWQ VRVTPQNFEP ITRPSWRNHT LTIKDTLCLT ELPFAGYNYT 300
  301 LRVRVRANQN NTLWSEPMIY AFATAPAPPR RPPRVTYGSF YVYSSEKAMR FYWEPLEEHE 360
  361 LNGPDFRYSI SEYRINGTAV DPGLIKVESN SAMIDHWSMS AVHHFLIRSS NSQGLSVNAT 420
  421 PMTIGPISNR DFKVREPRNI RSVYHPTNKS YTLSWDPPSD QRELQNYTVF WCVPKPGLQS 480
  481 ECEGSIRFAE VASGLHHFTT SPDQLLTLHM AVSANYQSHN TGLHWAICSS DKKDDLAKME 540
  541 PSIDVATSTS LTVSWSERVC AVILAGYNLT YCQRSAGRPD NCTTVTIDRY TNKHVIQNLV 600
  601 PYTDYSVKML MYSDSRVSKY SDELVNRTGE AAPSQPRELQ LIRVTSDSVE LAWKPPLLAN 660
  661 GVVRAYEGTF RSLHDNVTDT FRVSASADEL VNNEKPITYR LGNLTAFTKY EISVRARTVY 720
  721 PSEPSNVILF STAIGVPSPP QLYVINNPDQ SSRLDWEPPR TPAGRIDFYE ISLRDNNASC 780
  781 LTSTILPGRN LSYVMATPRC TSHNPFQLAV RAINVEQHPQ LNGADAAEGA VLLMSTNGKG 840
  841 CEARTDALGE EERLQFEAYA ANMTAYRLYR SDWGIYGFIC TPDTHSVKAM YQTIEVTVAI 900
  901 LVLGVIFYLV YKKYRKMSDI GLVLPQGIME TMKKPIDMGG LGLGLGPDSS VSGGIVCTRV 960
  961 DDSPPYTPQD LPHDFSSCGS ESSKLLLRTA SSSGGGGCVD RDGYDDNHET GPISAVGPPT1020
 1021 SYLAMRHGLL VQNDRERERE RDREQERERE QQQQQRESEM DREQSCTNGY IKPTQMKSWG1080
 1081 GNGPSDNDHT FSVPSTAMTA PMSQPLSQIP LSGYVPVPIP QSRFNPAPVQ PFGSPAVPSA1140
 1141 ATAAAASTFF PPAHLLNMDN YVQASDLHKL KPLVAAPLSQ TGGPAFAGSS PATSPPLQLP1200
 1201 PVHAASPAAA TPKMADIGYT TMEQLQLTGL IKPPLAATVG SPTHAAGGAP GGGNQHSRLQ1260
 1261 PQINGYVTPQ DLNAMAHNRH VL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..326] PSI-BLAST 33.30103 FRAGMENT OF HUMAN FIBRONECTIN ENCOMPASSING TYPE-III REPEATS 7 THROUGH 10
    2 View Details [327..1015] PSI-BLAST 36.0 No description for 2v5yA was found.
    3 View Details [1016..1282] deduced N/A No confident structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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