Protein Overview: FBpp0074230, par...

General Information:
Name(s) found:	FBpp0074230 [FlyBase] par-6-PA / FBpp0074229 [FlyBase]
Description(s) found: Found 33 descriptions. SHOW ALL	type=protein; loc=X:join(17597684..17597758,17598405..17598633,17598701..17599452); ID=FBpp0074230; name=par-6-PB; parent=FBgn0026192,FBtr0074456; dbxref=FlyBase:FBpp0074230,FlyBase_Annotation_IDs:CG5884-PB,GB_protein:AAN09592.1,GB_protein:AAN09592; MD5=9cb566ae07c2d057a38a5aa475204409; length=351; release=r5.56; species=Dmel; [FlyBase] The gene par-6 is referred to in FlyBase by the symbol Dmel\par-6 (CG5884, FBgn0026192). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:17597362..17601129. It has the cytological map location 16C1. There is experimental evidence that it has the molecular function</span>: protein binding. There is experimental evidence that it is involved in the biological process</span>: regulation of cell shape; synapse assembly; border follicle cell migration; cell adhesion; negative regulation of protein kinase activity; phagocytosis, engulfment. 12 alleles are reported. The phenotypes of these alleles are annotated with: embryonic/first instar larval cuticle; bouton; border follicle cell. It has one annotated transcript and one annotated polypeptide. [FlyBase]
Organism:	Drosophila melanogaster
Length:	351 amino acids
Gene Ontology:
Cellular Component:	subapical complex [TAS] cytoplasm [NAS] cell cortex [TAS] apical cortex [IDA][NAS] apical plasma membrane [TAS]
Biological Process:	regulation of cell shape [IMP] border follicle cell migration [IMP] cell adhesion [IMP] negative regulation of protein kinase activity [IDA] establishment or maintenance of neuroblast polarity [NAS] oocyte axis specification [TAS] synapse assembly [IMP] phagocytosis, engulfment [IMP] zonula adherens assembly [NAS][TAS] establishment or maintenance of epithelial cell apical/basal polarity [NAS][TAS] apical protein localization [NAS] morphogenesis of a polarized epithelium [TAS] establishment or maintenance of polarity of embryonic epithelium [NAS]
Molecular Function:	protein binding [IPI][ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKNKINTTS ATAASDTNLI EVKSKFDAEF RRWSFKRNEA EQSFDKFASL IEQLHKLTNI  60
   61 QFLILYIDPR DNDLLPINND DNFGRALKTA RPLLRVIVQR KDDLNEYSGF GTMKPRNLIG 120
  121 SILMGHTPVK TKAPSISIPH DFRQVSAIID VDIVPETHRR VRLLKHGSDK PLGFYIRDGT 180
  181 SVRVTASGLE KQPGIFISRL VPGGLAESTG LLAVNDEVIE VNGIEVAGKT LDQVTDMMVA 240
  241 NSSNLIITVK PANQRTLTST HRGSFSRNSQ LSSGSHHTNN TNTSDEIEHD DQDDIVDLTG 300
  301 VTLDESPTST SAGNHNHQPP LSSSPSSHHQ QAASNASTIM ASDVKDGVLH L

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Searching the YRC Public Image Repository, found results:

Currently showing to of results.

[View Search in the YRC Public Image Repository]

Searching the YRC Public Image Repository, found no results.

Ginzu Version Information

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Gene Ontology predictions

Term	Confidence	Notes
binding	1.60223908046747	bayes_pls_golite062009
protein binding	1.04550817342273	bayes_pls_golite062009
signal transducer activity	0.397569963508051	bayes_pls_golite062009
molecular transducer activity	0.397569963508051	bayes_pls_golite062009

Term	Confidence	Notes
binding	2.6196222853442	bayes_pls_golite062009
cytoskeletal protein binding	2.48224018205024	bayes_pls_golite062009
protein binding	2.35875654816667	bayes_pls_golite062009
actin binding	1.28302718651984	bayes_pls_golite062009
transporter activity	1.18978519116375	bayes_pls_golite062009
transmembrane transporter activity	1.07211582292329	bayes_pls_golite062009
substrate-specific transporter activity	0.755223974149211	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.549085929250683	bayes_pls_golite062009
PDZ domain binding	0.53069705861477	bayes_pls_golite062009
guanylate cyclase inhibitor activity	0.434298747650806	bayes_pls_golite062009
cyclase inhibitor activity	0.434298747650806	bayes_pls_golite062009
protein domain specific binding	0.30840185305841	bayes_pls_golite062009
ErbB-2 class receptor binding	0.261656236234201	bayes_pls_golite062009
active transmembrane transporter activity	0.252733105474942	bayes_pls_golite062009
molecular transducer activity	0.211809989510755	bayes_pls_golite062009
signal transducer activity	0.211809989510755	bayes_pls_golite062009
receptor binding	0.00333430733556384	bayes_pls_golite062009

No functions predicted.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.98

Source: Reynolds et al. (2008)

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..131]	PSI-BLAST	9.69897	Crystal structure of a PB1 domain complex of Protein kinase c iota and Par6 alpha
2	View Details	[132..267]	PSI-BLAST	25.522879	NMR Structure of the CRIB-PDZ module of Par-6
3	View Details	[268..351]	deduced	N/A	No confident structure predictions are available.

Protein Overview: FBpp0074230, par...

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: