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Protein Overview: RhoGAPp190-PA, R...

General Information:
Name(s) found: RhoGAPp190-PA / FBpp0074257 [FlyBase]
RhoGAPp190-PC / FBpp0074256 [FlyBase]
RhoGAPp190-PB / FBpp0074255 [FlyBase]
Description(s) found:
Found 43 descriptions.
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  • The gene RhoGAPp190 is referred to in FlyBase by the symbol Dmel\RhoGAPp190 (CG32555, FBgn0026375). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:17533176..17546585. It has the cytological map location 16B10. Based on sequence similarity, it is predicted to have molecular function</span>: Rho GTPase activator activity. There is experimental evidence that it is involved in the biological process</span>: regulation of axonogenesis; mushroom body development. 17 alleles are reported. The phenotypes of these alleles are annotated with: adult mushroom body; mushroom body beta-lobe; mushroom body vertical lobe. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
  • The gene RhoGAPp190 is referred to in FlyBase by the symbol Dmel\RhoGAPp190 (CG32555, FBgn0026375). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:17533176..17546585. It has the cytological map location 16B10. Based on sequence similarity, it is predicted to have molecular function</span>: Rho GTPase activator activity. There is experimental evidence that it is involved in the biological process</span>: regulation of axonogenesis; mushroom body development. 17 alleles are reported. The phenotypes of these alleles are annotated with: adult mushroom body; mushroom body beta-lobe; mushroom body vertical lobe. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
  • The gene RhoGAPp190 is referred to in FlyBase by the symbol Dmel\RhoGAPp190 (CG32555, FBgn0026375). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:17533176..17546585. It has the cytological map location 16B10. Based on sequence similarity, it is predicted to have molecular function</span>: Rho GTPase activator activity. There is experimental evidence that it is involved in the biological process</span>: regulation of axonogenesis; mushroom body development. 17 alleles are reported. The phenotypes of these alleles are annotated with: adult mushroom body; mushroom body beta-lobe; mushroom body vertical lobe. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1561 amino acids

    Gene Ontology:
    Cellular Component: intracellular [IEA]
    Biological Process: mushroom body development [IMP]
    signal transduction [IEA]
    regulation of axonogenesis [IGI]
    Molecular Function: Rho GTPase activator activity [ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRQFNISVIG LSGTEKDRGQ VGVGKSCLCN RFMRPMADDY FIDHISVLSQ SDFSGRIVNN  60
   61 DHFLYWGDVR KTTEEGVEYQ FNIIEQTEFM DDSTFQAFKV GKMDPYSKRC TATKVFSAEK 120
  121 LMYICKNQLG IEKEYEQKVM PDGRLSIDGF VVVFDVSPVP NRSVEKQVEF VQNVIATILK 180
  181 NKKPLVLVTT KNDDAYELYV REAEKISQRK DYKSTVQLIE TSAHESINID LAFLLLAQMI 240
  241 DKVKNRVKII SYQESAKSRK ELLDTRSEAV TRLIRNQITD YHVLWSQGSK MLSQYREWNE 300
  301 FLNIFGHEAG QKLFRRHMKK LRDDHLNKKL HQYLDKFALA LEYLLPDIGA LNISDDDAWE 360
  361 CARNYLQNHI EFEQYFFECP QASWTELVDM DEAEDEARIP FDVLETSEAE TVFRNYLNSV 420
  421 QQDKKKIGWK QQFKMLLEES GFVTPGKQLS EVRVLFMGRE CFEALSEHDC QQIYDIHQDD 480
  481 IIEKSKQNFV ELLLEHAQYF LQFKNVDNIT QEDVRQITDV IQEDSRYKML DRLDQERRLM 540
  541 LVQHLRFIHC PIRDHCPFFY NCVDSLIEEV LSDKSASNHK TPSGGGWKSS GSGSDRTLNL 600
  601 LIVGSEHLAS DLLNDIRICT GSKGEYIYEN QTYYLNYRIA NGDMEAFKAI DVYSSGLICV 660
  661 YSNQQSFETL KDNLERTLLC NLELEDKFEN LPIVLVYQPQ DLKENEVEYL RNEGMRLSEM 720
  721 LHCDFIDHTQ NHQKYVYDIL NIVILSLKLT EMKSYEPYPS NHTDLRILCC IFCGDQYDIE 780
  781 NIVQPLVEES TLVKANEHSI IVDVFIGDAK RRVEFILSSY HGTSQYRDEL IHGYIYFYST 840
  841 KRRSSLANLS ILAAQNANIP LQIIAVTESG GVNAFFNSDI CQFLITEGNA VADRFKGSFM 900
  901 TFSADQYVKF AFYNPFLKTA WDNKYEVENL HVEESITLDS GEGTLENSVN QMPRPPPRHE 960
  961 SYMLSNTLGT DGSGSENYEM APTRSLNSLN EERDISLDEI YDDNEKPKHL HQKWLEDKSD1020
 1021 GRRNMNKNLI WNNFSGSTHA YTTGRRHIDS NLNKIRPKGP SQTLKVGEAP SRNCPAMSSS1080
 1081 TFTLPTQQPG KLNMKNFQLV SDAVAKMNFT GSGSGSGSGS GSGSTGLGLG LGSGSGCMGD1140
 1141 SFLEPVDKDG KRYDHAQLDG EDEDSEELAE YEQIYENEDC TESDSCASST ERRVRQQNAY1200
 1201 YKASKKPVAA KKQKKKKVAI PVQTPRVPPF GSYVSPPEIP LHYQRMAVGG SGPEKPEPCV1260
 1261 PEFMKSDKSP EYSMVPELAG AGIFGAENLP EYNMNQAKCL KDFEKLEKRR IKEETARQRK1320
 1321 LQEKEKEQEK KLKRKLKQNA KGLVESAEAQ FGKLMITSEQ GEIPIFLNKC VEFIEKEGLD1380
 1381 SEGIYRVPGS RAHVDMLFQR FEEDTNTEID ALDIPVNAVA TALKDFFSKR LPPLFSKDII1440
 1441 KELEEIAGSR GVGNSKLNVE VKTDRSCRLI ALKSLLQKLP PINFAILKYI FQHFVHVSDN1500
 1501 SKLNSMDSKN LAICWWPTLI PIDFTDMGHF EQLRPYLEDI VQTMIDQFPY LFCGKDAFVM1560
 1561 V

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..226] PSI-BLAST 43.39794 Structure of doubly prenylated Ypt1:GDI complex
    2 View Details [227..560] PSI-BLAST 11.045757 Heavy meromyosin subfragment
    3 View Details [561..796] FFAS03 3.4 Structure of RabGDP-dissociation inhibitor in complex with prenylated YPT1 GTPase
    4 View Details [797..923] deduced N/A No confident structure predictions are available.
    5 View Details [924..1112] MSA 13.298997 View MSA. No confident structure predictions are available.
    6 View Details [1113..1311] deduced N/A No confident structure predictions are available.
    7 View Details [1312..1561] PSI-BLAST 48.39794 No description for 2ee5A was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  1.30574971150356 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.562985888331998 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.529737976676427 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.519184152871305 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.518588340023146 bayes_pls_golite062009
    2 No functions predicted.
    3
    Term Confidence Notes
  • binding
    		•  1.24194351030563 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.287179026036565 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.257973454506492 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.248489674630823 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.247952984919472 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle