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Protein Overview: Fim-PC

General Information:
Name(s) found: Fim-PC / FBpp0074216 [FlyBase]
Description(s) found:
Found 20 descriptions.
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  • The gene Fimbrin is referred to in FlyBase by the symbol Dmel\Fim (CG8649, FBgn0024238). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:17179736..17196011. It has the cytological map location 15F8-16A1. Based on sequence similarity, it is predicted to have molecular function</span>: actin binding. There is experimental evidence that it is involved in the biological process</span>: female meiosis chromosome segregation. 13 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 616 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: female meiosis chromosome segregation [IMP]
    Molecular Function: actin binding [IEA][ISS][NAS]
    calcium ion binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLDANKDGFI DLHELKDALN QVGFKLAGYQ VREMIDEYKG KQLTAFQGKL NLEEFEALCL  60
   61 DLKSKDVAST FKTVVSKKEN LETLGGMSSI SSEGTTHSVR LEEQLAFSDW INSNLGHDKD 120
  121 LQHLLPIDSE GKRLYLSIKD GILLCKIINH SCPDTIDERA INKKNLTVYR EFENLTLALV 180
  181 SSQAIGCNIV NIDAHDLAKG KPHLVLGLLW QIIRIGLFSH ITLDSCPGLA GLLFDNERLE 240
  241 DLMKMSPEAI LLRWVNHHLE RAGISRRCTN FQSDIVDSEI YSHLLKQIAG NDADVNLDAL 300
  301 RESDLQSRAE IMLQQAAKLN CRSFLTPQDV VNGVYKLNLA FVANLFNNHP GLDKPEQIEG 360
  361 LESIEETREE KTYRNWMNSM GVAPHVNWLY SDLADGLVIF QLFDVIKPGI VNWSRVHKRF 420
  421 SPLRKFMEKL ENCNYAVDLG KQLKFSLVGI AGQDLNDGNA TLTLALIWQL MRAYTLSILS 480
  481 RLANTGNPII EKEIVQWVNN RLSEAGKQSQ LRNFNDPAIA DGKIVIDLID AIKEGSINYE 540
  541 LVRTSGTQED NLANAKYAIS MARKIGARVY ALPEDITEVK PKMVMTVFAC MMALDYVPNM 600
  601 DSVDQNNHNS SANNSN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..78] PSI-BLAST 16.522879 THE LINKER OF DES-GLU84 CALMODULIN IS BENT AS SEEN IN THE CRYSTAL STRUCTURE
    2 View Details [79..616] PSI-BLAST 114.0 CRYSTAL STRUCTURE OF THE ACTIN-CROSSLINKING CORE OF SCHIZOSACCHAROMYCES POMBE FIMBRIN

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • actin binding
    		•  3.96919556235483 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  3.49668552859347 bayes_pls_golite062009
  • structural constituent of muscle
    		•  3.12414907235012 bayes_pls_golite062009
  • microfilament motor activity
    		•  2.9702957313812 bayes_pls_golite062009
  • binding
    		•  2.74623080162785 bayes_pls_golite062009
  • motor activity
    		•  2.57627414053278 bayes_pls_golite062009
  • actin filament binding
    		•  2.35534489389161 bayes_pls_golite062009
  • myosin binding
    		•  2.34125070430971 bayes_pls_golite062009
  • actin-dependent ATPase activity
    		•  2.06646671333275 bayes_pls_golite062009
  • calcium ion binding
    		•  1.40919295397643 bayes_pls_golite062009
  • ion binding
    		•  1.36376383271837 bayes_pls_golite062009
  • metal ion binding
    		•  1.34827363853601 bayes_pls_golite062009
  • cation binding
    		•  1.34827363853601 bayes_pls_golite062009
  • protein binding
    		•  1.16246005294206 bayes_pls_golite062009
  • transporter activity
    		•  1.15928534291452 bayes_pls_golite062009
  • actin monomer binding
    		•  0.9954841049256 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.945691505472547 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.841197898920128 bayes_pls_golite062009
  • structural molecule activity
    		•  0.800850121197479 bayes_pls_golite062009
  • S100 beta binding
    		•  0.761814775111873 bayes_pls_golite062009
  • tubulin binding
    		•  0.710693016758742 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.693724160233023 bayes_pls_golite062009
  • myosin heavy chain binding
    		•  0.61866037435065 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.582813108431922 bayes_pls_golite062009
  • DNA binding
    		•  0.50926539916695 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.45412801027969 bayes_pls_golite062009
  • myosin II binding
    		•  0.311147527050891 bayes_pls_golite062009
  • microtubule binding
    		•  0.278596514315141 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.267701820661496 bayes_pls_golite062009
  • signal transducer activity
    		•  0.267701820661496 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.246383459363256 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.193201281459889 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.168674124705245 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.116648335890738 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.0305250212662123 bayes_pls_golite062009
    2
    Term Confidence Notes
  • actin binding
    		•  7.50245214720686 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  6.48140000563569 bayes_pls_golite062009
  • actin filament binding
    		•  5.47084878097979 bayes_pls_golite062009
  • tubulin binding
    		•  4.22039137964246 bayes_pls_golite062009
  • microtubule binding
    		•  4.15537672860167 bayes_pls_golite062009
  • binding
    		•  2.8655705697659 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  2.57886434162184 bayes_pls_golite062009
  • protein binding
    		•  2.36488136094907 bayes_pls_golite062009
  • microtubule plus-end binding
    		•  2.0465241878708 bayes_pls_golite062009
  • structural constituent of muscle
    		•  1.32485442580942 bayes_pls_golite062009
  • structural molecule activity
    		•  1.00964022808548 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle