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View Structure Prediction Details

Protein: Fim-PC
Organism: Drosophila melanogaster
Length: 616 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Fim-PC.

Description E-value Query
Range
Subject
Range
gi|148237614, gi... - gi|38197331|gb|AAH61655.1| MGC68681 protein [Xenopus laevis], gi|148237614|ref|NP_001083581.1| hypot...
479.0 [0..2] [598..22]

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Predicted Domain #1
Region A:
Residues: [1-78]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLDANKDGFI DLHELKDALN QVGFKLAGYQ VREMIDEYKG KQLTAFQGKL NLEEFEALCL  60
   61 DLKSKDVAST FKTVVSKK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 16.522879
Match: 1degA
Description: THE LINKER OF DES-GLU84 CALMODULIN IS BENT AS SEEN IN THE CRYSTAL STRUCTURE
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
actin binding 3.96919556235483 bayes_pls_golite062009
cytoskeletal protein binding 3.49668552859347 bayes_pls_golite062009
structural constituent of muscle 3.12414907235012 bayes_pls_golite062009
microfilament motor activity 2.9702957313812 bayes_pls_golite062009
binding 2.74623080162785 bayes_pls_golite062009
motor activity 2.57627414053278 bayes_pls_golite062009
actin filament binding 2.35534489389161 bayes_pls_golite062009
myosin binding 2.34125070430971 bayes_pls_golite062009
actin-dependent ATPase activity 2.06646671333275 bayes_pls_golite062009
calcium ion binding 1.40919295397643 bayes_pls_golite062009
ion binding 1.36376383271837 bayes_pls_golite062009
metal ion binding 1.34827363853601 bayes_pls_golite062009
cation binding 1.34827363853601 bayes_pls_golite062009
protein binding 1.16246005294206 bayes_pls_golite062009
transporter activity 1.15928534291452 bayes_pls_golite062009
actin monomer binding 0.9954841049256 bayes_pls_golite062009
transmembrane transporter activity 0.945691505472547 bayes_pls_golite062009
transcription regulator activity 0.841197898920128 bayes_pls_golite062009
structural molecule activity 0.800850121197479 bayes_pls_golite062009
S100 beta binding 0.761814775111873 bayes_pls_golite062009
tubulin binding 0.710693016758742 bayes_pls_golite062009
substrate-specific transporter activity 0.693724160233023 bayes_pls_golite062009
myosin heavy chain binding 0.61866037435065 bayes_pls_golite062009
nucleic acid binding 0.582813108431922 bayes_pls_golite062009
DNA binding 0.50926539916695 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.45412801027969 bayes_pls_golite062009
myosin II binding 0.311147527050891 bayes_pls_golite062009
microtubule binding 0.278596514315141 bayes_pls_golite062009
molecular transducer activity 0.267701820661496 bayes_pls_golite062009
signal transducer activity 0.267701820661496 bayes_pls_golite062009
active transmembrane transporter activity 0.246383459363256 bayes_pls_golite062009
ion transmembrane transporter activity 0.193201281459889 bayes_pls_golite062009
transcription repressor activity 0.168674124705245 bayes_pls_golite062009
structural constituent of cytoskeleton 0.116648335890738 bayes_pls_golite062009
cation transmembrane transporter activity 0.0305250212662123 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [79-616]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ENLETLGGMS SISSEGTTHS VRLEEQLAFS DWINSNLGHD KDLQHLLPID SEGKRLYLSI  60
   61 KDGILLCKII NHSCPDTIDE RAINKKNLTV YREFENLTLA LVSSQAIGCN IVNIDAHDLA 120
  121 KGKPHLVLGL LWQIIRIGLF SHITLDSCPG LAGLLFDNER LEDLMKMSPE AILLRWVNHH 180
  181 LERAGISRRC TNFQSDIVDS EIYSHLLKQI AGNDADVNLD ALRESDLQSR AEIMLQQAAK 240
  241 LNCRSFLTPQ DVVNGVYKLN LAFVANLFNN HPGLDKPEQI EGLESIEETR EEKTYRNWMN 300
  301 SMGVAPHVNW LYSDLADGLV IFQLFDVIKP GIVNWSRVHK RFSPLRKFME KLENCNYAVD 360
  361 LGKQLKFSLV GIAGQDLNDG NATLTLALIW QLMRAYTLSI LSRLANTGNP IIEKEIVQWV 420
  421 NNRLSEAGKQ SQLRNFNDPA IADGKIVIDL IDAIKEGSIN YELVRTSGTQ EDNLANAKYA 480
  481 ISMARKIGAR VYALPEDITE VKPKMVMTVF ACMMALDYVP NMDSVDQNNH NSSANNSN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 114.0
Match: 1rt8A
Description: CRYSTAL STRUCTURE OF THE ACTIN-CROSSLINKING CORE OF SCHIZOSACCHAROMYCES POMBE FIMBRIN
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
actin binding 7.50245214720686 bayes_pls_golite062009
cytoskeletal protein binding 6.48140000563569 bayes_pls_golite062009
actin filament binding 5.47084878097979 bayes_pls_golite062009
tubulin binding 4.22039137964246 bayes_pls_golite062009
microtubule binding 4.15537672860167 bayes_pls_golite062009
binding 2.8655705697659 bayes_pls_golite062009
structural constituent of cytoskeleton 2.57886434162184 bayes_pls_golite062009
protein binding 2.36488136094907 bayes_pls_golite062009
microtubule plus-end binding 2.0465241878708 bayes_pls_golite062009
structural constituent of muscle 1.32485442580942 bayes_pls_golite062009
structural molecule activity 1.00964022808548 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle