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Protein Overview: baz-PA

General Information:
Name(s) found: baz-PA / FBpp0074162 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • The gene bazooka is referred to in FlyBase by the symbol Dmel\baz (CG5055, FBgn0000163). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:17054062..17089350. It has the cytological map location 15F1. There is experimental evidence that it has the molecular function</span>: protein binding. There is experimental evidence for 12 unique biological process</span> terms, many of which group under: anatomical structure development; reproductive process in a multicellular organism; ovarian follicle cell development; cell division; cell morphogenesis; establishment or maintenance of cell polarity; delamination; cell junction organization; cell fate commitment; cell fate determination. 54 alleles are reported. The phenotypes of these alleles are annotated with 17 unique terms, many of which group under: organ system; anatomical structure; nervous system; plasma membrane part; cell component; plasma membrane; portion of tissue; anchoring junction; integumentary system; embryonic head; zonula adherens; embryonic nervous system; female germline cyst; peripheral nervous system; late extended germ band embryo. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1464 amino acids

    Gene Ontology:
    Cellular Component: apicolateral plasma membrane [TAS]
    adherens junction [IEP]
    subapical complex [TAS]
    apical part of cell [NAS]
    spot adherens junction [IDA]
    cell-cell adherens junction [NAS]
    cytoplasm [NAS]
    cell cortex [TAS]
    apical junction complex [IEP]
    apical cortex [NAS][TAS]
    apical plasma membrane [NAS][TAS]
    Biological Process: establishment of apical/basal cell polarity [IMP]
    germarium-derived oocyte fate determination [IMP]
    protein localization [TAS]
    germ-band extension [IMP][TAS]
    border follicle cell delamination [IMP]
    cytokinesis [IMP]
    border follicle cell migration [IMP]
    ovarian follicle cell-cell adhesion [IMP]
    asymmetric protein localization [TAS]
    establishment or maintenance of neuroblast polarity [NAS]
    oocyte axis specification [TAS]
    basal protein localization [TAS]
    establishment or maintenance of epithelial cell apical/basal polarity [IMP][NAS][TAS]
    apical protein localization [NAS]
    establishment or maintenance of polarity of embryonic epithelium [NAS]
    establishment of mitotic spindle localization [TAS]
    cell-cell junction assembly [NAS]
    establishment or maintenance of cell polarity [NAS]
    asymmetric cell division [TAS]
    synapse assembly [IMP]
    morphogenesis of an epithelium [NAS][TAS]
    asymmetric protein localization involved in cell fate determination [IMP]
    zonula adherens assembly [IMP][NAS][TAS]
    morphogenesis of a polarized epithelium [TAS]
    asymmetric neuroblast division [IGI][IMP]
    Molecular Function: protein kinase C binding [ISS]
    protein binding [IPI][ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKVTVCFGDV RILVPCGSGE LLVRDLVKEA TRRYIKAAGK PDSWVTVTHL QTQSGILDPD  60
   61 DCVRDVADDR EQILAHFDDP GPDPGVPQGG GDGASGSSSV GTGSPDIFRD PTNTEAPTCP 120
  121 RDLSTPHIEV TSTTSGPMAG LGVGLMVRRS SDPNLLASLK AEGSNKRWSA AAPHYAGGDS 180
  181 PERLFLDKAG GQLSPQWEED DDPSHQLKEQ LLHQQQPHAA NGGSSSGNHQ PFARSGRLSM 240
  241 QFLGDGNGYK WMEAAEKLQN QPPAQQTYQQ GSHHAGHGQN GAYSSKSLPR ESKRKEPLGQ 300
  301 AYESIREKDG EMLLIINEYG SPLGLTALPD KEHGGGLLVQ HVEPGSRAER GRLRRDDRIL 360
  361 EINGIKLIGL TESQVQEQLR RALESSELRV RVLRGDRNRR QQRDSKVAEM VEVATVSPTR 420
  421 KPHAAPVGTS LQVANTRKLG RKIEIMLKKG PNGLGFSVTT RDNPAGGHCP IYIKNILPRG 480
  481 AAIEDGRLKP GDRLLEVDGT PMTGKTQTDV VAILRGMPAG ATVRIVVSRQ QELAEQADQP 540
  541 AEKSAGVAVA PSVAPPAVPA AAAPAPPIPV QKSSSARSLF THQQQSQLNE SQHFIDAGSE 600
  601 SAASNDSLPP SSNSWHSREE LTLHIPVHDT EKAGLGVSVK GKTCSNLNAS GSSASSGSNG 660
  661 LMKHDGDLGI FVKNVIHGGA ASRDGRLRMN DQLLSVNGVS LRGQNNAEAM ETLRRAMVNT 720
  721 PGKHPGTITL LVGRKILRSA SSSDILDHSN SHSHSHSNSS GGSNSNGSGN NNNSSSNASD 780
  781 NSGATVIYLS PEKREQRCNG GGGGGSAGNE MNRWSNPVLD RLTGGICSSN SAQPSSQQSH 840
  841 QQQPHPSQQQ QQQRRLPAAP VCSSAALRNE SYYMATNDNW SPAQMHLMTA HGNTALLIED 900
  901 DAEPMSPTLP ARPHDGQHCN TSSANPSQNL AVGNQGPPIN TVPGTPSTSS NFDATYSSQL 960
  961 SLETNSGVEH FSRDALGRRS ISEKHHAALD ARETGTYQRN KKLREERERE RRIQLTKSAV1020
 1021 YGGSIESLTA RIASANAQFS GYKHAKTASS IEQRETQQQL AAAEAEARDQ LGDLGPSLGM1080
 1081 KKSSSLESLQ TMVQELQMSD EPRGHQALRA PRGRGREDSL RAAVVSEPDA SKPRKTWLLE1140
 1141 DGDHEGGFAS QRNGPFQSSL NDGKHGCKSS RAKKPSILRG IGHMFRFGKN RKDGVVPVDN1200
 1201 YAVNISPPTS VVSTATSPQL QQQQQQQLQQ HQQQQQIPTA ALAALERNGK PPAYQPPPPL1260
 1261 PAPNGVGSNG IHQNDIFNHR YQHYANYEDL HQQHQQHQIS RRHQHYHSQR SARSQDVSMH1320
 1321 STSSGSQPGS LAQPQAQSNG VRPMSSYYEY ETVQQQRVGS IKHSHSSSAT SSSSSPINVP1380
 1381 HWKAAAMNGY SPASLNSSAR SRGPFVTQVT IREQSSGGIP AHLLQQHQQQ QLQQQQPTYQ1440
 1441 TVQKMSGPSQ YGSAAGSQPH ASKV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..71] PSI-BLAST 23.045757 No description for 2ns5A was found.
    2 View Details [72..302] deduced N/A No confident structure predictions are available.
    3 View Details [303..416] PSI-BLAST 18.154902 Solution structure of the alternatively spliced PDZ2 domain (PDZ2b) of PTP-Bas (hPTP1E)
    4 View Details [417..579] PSI-BLAST 22.30103 The crystal structure of the 13th PDZ domain of MPDZ
    5 View Details [580..630] deduced N/A No confident structure predictions are available.
    6 View Details [631..878] FFAS03 3.69 solution structure of the split PH-PDZ Supramodule of alpha-Syntrophin
    7 View Details [879..950] deduced N/A No confident structure predictions are available.
    8 View Details [951..1273] PSI-BLAST 22.0 Psd-95; Guanylate kinase-like domain of Psd-95
    9 View Details [1274..1464] MSA 2.108991 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • cytoskeletal protein binding
    		•  3.8598579619264 bayes_pls_golite062009
  • actin binding
    		•  2.68527541003929 bayes_pls_golite062009
  • binding
    		•  2.6196222853442 bayes_pls_golite062009
  • protein binding
    		•  2.35875654816667 bayes_pls_golite062009
  • actin filament binding
    		•  1.28158096626765 bayes_pls_golite062009
  • receptor binding
    		•  1.19273986711251 bayes_pls_golite062009
  • transporter activity
    		•  1.14862709059264 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.03502943752333 bayes_pls_golite062009
  • beta-catenin binding
    		•  0.740091060781601 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.724101421194961 bayes_pls_golite062009
  • cyclase inhibitor activity
    		•  0.719523854982412 bayes_pls_golite062009
  • guanylate cyclase inhibitor activity
    		•  0.719523854982412 bayes_pls_golite062009
  • PDZ domain binding
    		•  0.71844819286977 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.520243659117793 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  0.403457741099606 bayes_pls_golite062009
  • protein domain specific binding
    		•  0.30840185305841 bayes_pls_golite062009
  • ErbB-2 class receptor binding
    		•  0.261656236234201 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.221504678128513 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.211809989510755 bayes_pls_golite062009
  • signal transducer activity
    		•  0.211809989510755 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.
    8 No functions predicted.
    9 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle