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Protein Overview: Fur2-PD, Fur2-PG...

General Information:
Name(s) found: Fur2-PG / FBpp0089399 [FlyBase]
Fur2-PE / FBpp0074043 [FlyBase]
Fur2-PF / FBpp0074041 [FlyBase]
Fur2-PD / FBpp0074039 [FlyBase]
Description(s) found:
Found 60 descriptions.
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  • The gene Furin 2 is referred to in FlyBase by the symbol Dmel\Fur2 (CG18734, FBgn0004598). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:16267121..16275816. It has the cytological map location 14C1-14C2. There is experimental evidence that it has the molecular function</span>: serine-type endopeptidase activity. It is reported to be involved in the biological process</span>: proteolysis. 10 alleles are reported. No phenotypic data is available. It has 9 annotated transcripts and 9 annotated polypeptides. [FlyBase]
  • The gene Furin 2 is referred to in FlyBase by the symbol Dmel\Fur2 (CG18734, FBgn0004598). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:16267121..16275816. It has the cytological map location 14C1-14C2. There is experimental evidence that it has the molecular function</span>: serine-type endopeptidase activity. It is reported to be involved in the biological process</span>: proteolysis. 10 alleles are reported. No phenotypic data is available. It has 9 annotated transcripts and 9 annotated polypeptides. [FlyBase]
  • The gene Furin 2 is referred to in FlyBase by the symbol Dmel\Fur2 (CG18734, FBgn0004598). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:16267121..16275816. It has the cytological map location 14C1-14C2. There is experimental evidence that it has the molecular function</span>: serine-type endopeptidase activity. It is reported to be involved in the biological process</span>: proteolysis. 10 alleles are reported. No phenotypic data is available. It has 9 annotated transcripts and 9 annotated polypeptides. [FlyBase]
  • The gene Furin 2 is referred to in FlyBase by the symbol Dmel\Fur2 (CG18734, FBgn0004598). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:16267121..16275816. It has the cytological map location 14C1-14C2. There is experimental evidence that it has the molecular function</span>: serine-type endopeptidase activity. It is reported to be involved in the biological process</span>: proteolysis. 10 alleles are reported. No phenotypic data is available. It has 9 annotated transcripts and 9 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1679 amino acids

    Gene Ontology:
    Cellular Component: plasma membrane [ISS]
    Biological Process: proteolysis [IEA][NAS]
    transmembrane receptor protein tyrosine kinase signaling pathway [IEA]
    protein amino acid phosphorylation [IEA]
    Molecular Function: ATP binding [IEA]
    transmembrane receptor protein tyrosine kinase activity [IEA]
    serine-type endopeptidase activity [IDA][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNTTRSSRV TIGRIGTTPQ ITDPWSSGLE KQRPSRCGGP KSLAEPTYRK IGRRKMMLHM  60
   61 RVHDPGTTVT QRAKETATAK LNRIYLCTFN RMAQSCIYFV LFLVILSPNT SCALRSSAGE 120
  121 TQNYVGILSN DSATTTYDVS SLHSSRRTNP PSSSSSSSSN VDVDYRNDRE LHKVDLVGLG 180
  181 GERAGQAETI SGGKYDYNYE NTHTNASAKD EIVERQSNSL DFDGVDMFGA FSIPEEAIYT 240
  241 NEFAVNIPAG KQMADVIATK HGFINRGQIG SLDNYYLFQH HHVSKRSLRS SRKHQGALKS 300
  301 ENEVKWMQQQ HEKVRRKRDG PYQDLPTYSP YNLLRQHGGY VVDPNPHLSF SPESISLASH 360
  361 SQRMEYRDVS SHFIFPDPLF KEQWYLNGGA KDGLDMNVGP AWQKGYTGKG VVVSILDDGI 420
  421 QTNHPDLAQN YDPEASFDIN GNDSDPTPQD NGDNKHGTRC AGEVAAVAFN NFCGVGVAYN 480
  481 ASIGGVRMLD GKVNDVVEAQ ALSLNPSHID IYSASWGPED DGSTVDGPGP LARRAFIYGV 540
  541 TSGRQGKGSI FVWASGNGGR YTDSCNCDGY TNSIFTLSIS SATQAGFKPW YLEECSSTLA 600
  601 TTYSSGTPGH DKSVATVDMD GSLRPDHICT VEHTGTSASA PLAAGICALA LEANPELTWR 660
  661 DMQYLVVYTS RPAPLEKENG WTLNGVKRKY SHKFGYGLMD AGAMVSLAEQ WTSVPPQHIC 720
  721 KSRENNEDRK IDGAYGSTLS THMDVNGCAG TINEVRYLEH VQCRITLRFF PRGNLRILLT 780
  781 SPMGTTSTLL FERPRDIVKS NFDDWPFLSV HFWGEKAEGR WTLQVINGGR RRVNQPGILS 840
  841 KWQLIFYGTS TQPMRLKSEL LNSSPQLRSP SSSNPFLFPS ASNIGQPANE GGNFNTDSFA 900
  901 SYLNYQNIFS SAGSDPEPAT ATLDGQNVTA AIAGGSSAES LGFTASAAQL VAAPETRDGD 960
  961 KKILHSCDAE CDSSGCYGRG PTQCVACSHY RLDNTCVSRC PPRSFPNQVG ICWPCHDTCE1020
 1021 TCAGAGPDSC LTCAPAHLHV IDLAVCLQFC PDGYFENSRN RTCVPCEPNC ASCQDHPEYC1080
 1081 TSCDHHLVMH EHKCYSACPL DTYETEDNKC AFCHSTCATC NGPTDQDCIT CRSSRYAWQN1140
 1141 KCLISCPDGF YADKKRLECM PCQEGCKTCT SNGVCSECLQ NWTLNKRDKC IVSGSEGCSE1200
 1201 SEFYSQVEGQ CRPCHASCGS CNGPADTSCT SCPPNRLLEQ SRCVSGCREG FFVEAGSLCS1260
 1261 PCLHTCSQCV SRTNCSNCSK GLELQNGECR TTCADGYYSD RGICAKCYLS CHTCSGPRRN1320
 1321 QCVQCPAGWQ LAAGECHPEC PEGFYKSDFG CQKCHHYCKT CNDAGPLACT SCPPHSMLDG1380
 1381 GLCMECLSSQ YYDTTSATCK TCHDSCRSCF GPGQFSCKGC VPPLHLDQLN SQCVSCCQNQ1440
 1441 TLAEKTSSAA CCNCDGETGE CKATSTGGKR RTVVGSGSAY KSSESKHGSF ENDGNAREFV1500
 1501 LRLDSPLTAI TAIAVAICLL IITIFSIIFA VLQRNSNHVS RNSVRYRKIA NTSSGRRKNL1560
 1561 SAKPTSDARF IFNIGEDDDT DGDNSDDELD GNVGTDINNR IVYDRKGNDH GHEFYIESTN1620
 1621 DIDAIEFHCN GAGAQKAETQ LQRCNANGDD DDILHYDRHT NAERKNHPSS TTSRTNIRS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..209] deduced N/A No confident structure predictions are available.
    2 View Details [210..327] PSI-BLAST 22.69897 Prohormone convertase 1 pro-domain
    3 View Details [328..825] PSI-BLAST 163.0 Furin, C-terminal domain; Furin, N-terminal domain
    4 View Details [826..873] PSI-BLAST 3.154902 No description for 2dw0A was found.
    5 View Details [874..1395] PSI-BLAST 5.154902 EGF receptor extracellular domain; EGF receptor Cys-rich domains
    6 View Details [1396..1575] PSI-BLAST 10.69897 Hybrid domain of integrin beta; Integrin beta A domain; Integrin beta tail domain; Integrin beta EGF-like domains
    7 View Details [1576..1679] deduced N/A No confident structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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