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Protein Overview: vap-PD, vap-PA, ...

General Information:
Name(s) found: FBpp0309362 [FlyBase]
FBpp0309361 [FlyBase]
vap-PD / FBpp0089148 [FlyBase]
vap-PA / FBpp0089147 [FlyBase]
vap-PC / FBpp0073946 [FlyBase]
vap-PB / FBpp0073945 [FlyBase]
Description(s) found:
Found 69 descriptions.
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  • type=protein; loc=X:complement(15894470..15894618,15894701..15894851,15894917..15895823,15895896..15896745,15896919..15897328,15897410..15897482,15897562..15897675,15897748..15897958); ID=FBpp0309362; name=vap-PF; parent=FBgn0003969,FBtr0340416; dbxref=FlyBase:FBpp0309362,FlyBase_Annotation_IDs:CG9209-PF; MD5=e25743e90ff079e902e4351494544262; length=954; release=r5.56; species=Dmel; [FlyBase]
  • type=protein; loc=X:complement(15894470..15894618,15894701..15894851,15894917..15895823,15895896..15896745,15896919..15897328,15897410..15897482,15897562..15897675,15897748..15897958); ID=FBpp0309361; name=vap-PE; parent=FBgn0003969,FBtr0340415; dbxref=FlyBase:FBpp0309361,FlyBase_Annotation_IDs:CG9209-PE; MD5=e25743e90ff079e902e4351494544262; length=954; release=r5.56; species=Dmel; [FlyBase]
  • The gene vacuolar peduncle is referred to in FlyBase by the symbol Dmel\vap (CG9209, FBgn0003969). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:15894167..15899877. It has the cytological map location 14A5-14A6. Based on sequence similarity, it is predicted to have molecular function</span>: Ras GTPase activator activity. There is experimental evidence that it is involved in the biological process</span>: mushroom body development; behavioral response to ethanol. 24 alleles are reported. The phenotypes of these alleles are annotated with: optic lobe; nodulus; wing; ellipsoid body; adult brain. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
  • The gene vacuolar peduncle is referred to in FlyBase by the symbol Dmel\vap (CG9209, FBgn0003969). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:15894167..15899877. It has the cytological map location 14A5-14A6. Based on sequence similarity, it is predicted to have molecular function</span>: Ras GTPase activator activity. There is experimental evidence that it is involved in the biological process</span>: mushroom body development; behavioral response to ethanol. 24 alleles are reported. The phenotypes of these alleles are annotated with: optic lobe; nodulus; wing; ellipsoid body; adult brain. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
  • The gene vacuolar peduncle is referred to in FlyBase by the symbol Dmel\vap (CG9209, FBgn0003969). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:15894167..15899877. It has the cytological map location 14A5-14A6. Based on sequence similarity, it is predicted to have molecular function</span>: Ras GTPase activator activity. There is experimental evidence that it is involved in the biological process</span>: mushroom body development; behavioral response to ethanol. 24 alleles are reported. The phenotypes of these alleles are annotated with: optic lobe; nodulus; wing; ellipsoid body; adult brain. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
  • The gene vacuolar peduncle is referred to in FlyBase by the symbol Dmel\vap (CG9209, FBgn0003969). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:15894167..15899877. It has the cytological map location 14A5-14A6. Based on sequence similarity, it is predicted to have molecular function</span>: Ras GTPase activator activity. There is experimental evidence that it is involved in the biological process</span>: mushroom body development; behavioral response to ethanol. 24 alleles are reported. The phenotypes of these alleles are annotated with: optic lobe; nodulus; wing; ellipsoid body; adult brain. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 954 amino acids

    Gene Ontology:
    Cellular Component: intracellular [IEA]
    Biological Process: mushroom body development [IMP]
    regulation of small GTPase mediated signal transduction [IEA]
    behavioral response to ethanol [IMP]
    Molecular Function: protein binding [IEA]
    Ras GTPase activator activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MADLIHLGNI DVVIQKDKPG SPTGCSDDGN LAGLGGMTGL GGIMAPGGID LGDLAQELDH  60
   61 DEFDGPHMLN GERPAIIAPP ESEWYHGRLD RYSAESRLRG SSKLGSYLVR ESDRKPGSYV 120
  121 LSYYGRTGIN HFRITAVCGD FYIGGRQFIS LSDLVGYYTS CSDLLKRERL AIPVAPPEPV 180
  181 NDKKRVVAIL PYTKMPETDE LSFQKGDIFF VHNDMGDGWL WVTAHRTGEQ GMIFRELVDD 240
  241 LDVSIDPNTV FPWFHPNCTK NEAVDMLVKA GPGSFLVRPS DNSPGDYSLF FHINNQIQRF 300
  301 RIEKKGVRYL MGGRTFECLD AVINRYRKEQ IVEGHSLNHP VVNGIQPEFN QQYVVEKAAE 360
  361 KIYATLRECR DQIGLKKIKG IKHHGHLNKK SDKTTKWKQL YFALINDGSE TQLCFYDNPK 420
  421 KTKPKGLIDL SCAYLYQCHD SLWERPYCFQ IVERALPCLA TVTYLCAPSQ ESYVEWINSL 480
  481 KAQCDSQLSR AQKKVSRLRE LRCLNLHVLE AHRLPFKLVP HPYCSISLNQ VKVGKTRVKI 540
  541 APEPVWEEEF VLDDVPPDVV SLTITLISRG KRGKDSEVAE LTIDLSSLKN GQETEGWYQL 600
  601 TGMTPMGEWG SLRLRMRYLD DLIMPCEEYS PLQQLLLESE LYAVKALAEL CHNDRVPLAT 660
  661 ALLRVFRQEK RETELIRMLC QAEVTRENET TTLFRGASLA TTLMDLYMRT ECSGFLQSAV 720
  721 SETVQRILES KQSAELNPTK MDVNDDACTN AEFLLQILDL VTQSIFTSPD ACPRNVRFIC 780
  781 SCLQKAVMAK WPTERLVRTR VVSGFIFLRL LCPALLNPRQ FGLVSETPPM AATRSLVMVA 840
  841 KCLQNLANLI EFGGKEQYME VVNPFILKNK ERMIVFLDQL SSVNDPNQPL GMFVEQSTNL 900
  901 NSQDTGRELA TLHHICVSHS QELHELSNIL SIKKLVTVTD MLTKHKLKYR EMIS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..77] PSI-BLAST 60.522879 No description for 2h8hA was found.
    2 View Details [78..651] PSI-BLAST 22.522879 Crystal structure of human tyrosine phosphatase SHP-1
    3 View Details [652..954] PSI-BLAST 85.30103 RAS-GTPASE-ACTIVATING DOMAIN OF HUMAN P120GAP

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • GTPase regulator activity
    		•  3.92341792218401 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  3.90121360274392 bayes_pls_golite062009
  • small GTPase regulator activity
    		•  3.62030771158759 bayes_pls_golite062009
  • Ras GTPase activator activity
    		•  3.57820175827805 bayes_pls_golite062009
  • enzyme regulator activity
    		•  3.46826704310039 bayes_pls_golite062009
  • Rho GTPase activator activity
    		•  3.36729905538951 bayes_pls_golite062009
  • GTPase activator activity
    		•  3.18597454327808 bayes_pls_golite062009
  • enzyme activator activity
    		•  2.92839426561878 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.61125915250884 bayes_pls_golite062009
  • actin binding
    		•  2.416122069016 bayes_pls_golite062009
  • Rac GTPase activator activity
    		•  2.11791567976149 bayes_pls_golite062009
  • binding
    		•  1.62780792681766 bayes_pls_golite062009
  • microfilament motor activity
    		•  1.44575799226586 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.42814294153578 bayes_pls_golite062009
  • signal transducer activity
    		•  1.42814294153578 bayes_pls_golite062009
  • actin filament binding
    		•  1.3598230579803 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.26917632007176 bayes_pls_golite062009
  • protein binding
    		•  1.21496582666968 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.01803522412345 bayes_pls_golite062009
  • DNA binding
    		•  0.813358382068686 bayes_pls_golite062009
  • receptor activity
    		•  0.434186339265983 bayes_pls_golite062009
  • actin-dependent ATPase activity
    		•  0.09145723094381 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle