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Protein Overview: CG8939-PA

General Information:
Name(s) found: CG8939-PA / FBpp0073943 [FlyBase]
Description(s) found:
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  • gi|7293173|gb|AAF48557.1| CG8939 [Drosophila melanogaster] [NCBI NR]
  • gi|18859957|ref|NP_573099.1| CG8939 [Drosophila melanogaster] [NCBI NR]
  • gi|17862372|gb|AAL39663.1| LD23718p [Drosophila melanogaster] [NCBI NR]
  • This gene is referred to in FlyBase by the symbol Dmel\CG8939 (CG8939, FBgn0030720). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:15891070..15893732. It has the cytological map location 14A5. Based on sequence similarity, it is predicted to have molecular function</span>: rRNA methyltransferase activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: rRNA processing. One allele is reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
  • >CG8939-PA translation from_gene[CG8939 CG8939 FBgn0030720] seq_release:3 mol_weight=93348 cds_boundaries:(X:15,728,139..15,730,650[+]) aa_length:817 transcript_info:[CG8939-RA seq_release:3] gene_info:[gene symbol:CG8939 FBgn0030720 gene_boundaries:(X [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q9VXK5) CG8939 protein (LD23718p) [DrosMelano7227.FASTAC.txt]
  • (AE003500) CG8939 gene product [Drosophila melanogaster] [yeastflysequest.fasta]
  • CG8939-PA [Drosophila melanogaster]gi|17862372|gb|AAL39663.1| LD23718p [Drosophila melanogaster]gi|18859957|ref|NP_573099.1| CG8939-PA [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=X:join(15891157..15893017,15893079..15893671); ID=FBpp0073943; name=CG8939-PA; parent=FBgn0030720,FBtr0074138; dbxref=FlyBase:FBpp0073943,FlyBase_Annotation_IDs:CG8939-PA,GB_protein:AAF48557.1,REFSEQ:NP_573099,GB_protein:AAF48557; MD5=c1 [fly-100309-contam.fasta]
  • CG8939-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • LD23718p [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=X:join(15891157..15893017,15893079..15893671); ID=FBpp0073943; name=CG8939-PA; parent=FBgn0030720,FBtr0074138; dbxref=FlyBase:FBpp0073943,FlyBase_Annotation_IDs:CG8939-PA,GB_protein:AAF48557.1,REFSEQ:NP_573099,GB_protein:AAF48557; MD5=c150e2baa3e928286bbd98dd739084c6; length=817; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=X:join(15891157..15893017,15893079..15893671); ID=FBpp0073943; name=CG8939-PA; parent=FBgn0030720,FBtr0074138; dbxref=FlyBase:FBpp0073943,FlyBase_Annotation_IDs:CG8939-PA,GB_protein:AAF48557.1,REFSEQ:NP_573099,GB_protein:AAF48557; MD5=c150e2baa3e928286bbd98dd739084c6; length=817; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • CG8939 OS=Drosophila melanogaster GN=CG8939 PE=1 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=X:join(15891157..15893017,15893079..15893671); ID=FBpp0073943; name=CG8939-PA; parent=FBgn0030720,FBtr0074138; dbxref=FlyBase:FBpp0073943,FlyBase_Annotation_IDs:CG8939-PA,GB_protein:AAF48557.1,REFSEQ:NP_573099,GB_protein:AAF48557,FlyMine:FBpp0073943,modMine:FBpp0073943; MD5=c150e2baa3e928286bbd98dd739084c6; length=817; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • CG8939 OS=Drosophila melanogaster GN=CG8939 PE=2 SV=1 [UniProt_D_Melanogaster_07132012_07-13-2012_reversed.fasta]
  • type=protein; loc=X:join(15997124..15998984,15999046..15999638); ID=FBpp0073943; name=CG8939-PA; parent=FBgn0030720,FBtr0074138; dbxref=FlyBase:FBpp0073943,FlyBase_Annotation_IDs:CG8939-PA,GB_protein:AAF48557.1,REFSEQ:NP_573099,GB_protein:AAF48557,FlyMine:FBpp0073943,modMine:FBpp0073943; MD5=c150e2baa3e928286bbd98dd739084c6; length=817; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=X:join(15997124..15998984,15999046..15999638); ID=FBpp0073943; name=CG8939-PA; parent=FBgn0030720,FBtr0074138; dbxref=FlyBase:FBpp0073943,FlyBase_Annotation_IDs:CG8939-PA,GB_protein:AAF48557.1,REFSEQ:NP_573099,GB_protein:AAF48557,FlyMine:FBpp0073943,modMine:FBpp0073943; MD5=c150e2baa3e928286bbd98dd739084c6; length=817; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • Putative rRNA methyltransferase OS=Drosophila melanogaster GN=CG8939 PE=1 SV=1 [DROME.fasta.20160308]
  • FBpp0073943 type=protein; loc=X:join(15997124..15998984,15999046..15999638); ID=FBpp0073943; name=CG8939-PA; parent=FBgn0030720,FBtr0074138; dbxref=FlyBase:FBpp0073943,FlyBase_Annotation_IDs:CG8939-PA,GB_protein:AAF48557.1,REFSEQ:NP_573099,GB_protein:AAF48557,FlyMine:FBpp0073943,modMine:FBpp0073943; MD5=c150e2baa3e928286bbd98dd739084c6; length=817; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=X:join(15997124..15998984,15999046..15999638); ID=FBpp0073943; name=CG8939-PA; parent=FBgn0030720,FBtr0074138; dbxref=FlyBase:FBpp0073943,FlyBase_Annotation_IDs:CG8939-PA,GB_protein:AAF48557.1,REFSEQ:NP_573099,GB_protein:AAF48557,UniProt/TrEMBL:Q9VXK5,FlyMine:FBpp0073943,modMine:FBpp0073943; MD5=c150e2baa3e928286bbd98dd739084c6; length=817; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 817 amino acids

    Gene Ontology:
    Cellular Component: nucleolus [ISS]
    Biological Process: rRNA methylation [IEA]
    rRNA processing [ISS]
    Molecular Function: nucleic acid binding [IEA]
    rRNA methyltransferase activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGKKTKVGKT RKDKFYQLAK ETGLRSRAAF KLIQLNRKFG FLQQSQVCLD LCAAPGGWMQ  60
   61 VAKQNMPVSS IVIGVDLFPI RPIAGCIGLV EDITTEKCRQ SLTKELQSWK ADVVLHDGAP 120
  121 NVGRNWLYDA YQQICLTLNA LKLSTQFLRN GGWFVTKVFR SKDYNALLWV LKQLFKKVHA 180
  181 TKPSASRKES AEIFVVCQGY LAPDHIDPRL LDSKYVFEEL DLDAKKKSSL LHPEKQKRIK 240
  241 AEGYTAQDIA LRNDLAATEF LKAENALAAL QGIGSIRIDD QRIANHKKTT PEILECCKDL 300
  301 KVLGRKDIKG LVQWWKDVRE LFVEKETPLV VGNAADEKPK PLTQAEIEDM EDAELQTQIE 360
  361 TIVEEEKKDL KRKRKKTLKT KAKLHEKMNL NMVIKGDDGP VEEMEHEIFD LKNIRTSAEL 420
  421 DELLDVQPDF AVDESQPEET KLPKYKYFDK DEGNINDDLN YDDDNDEEQS EASDDEDQIN 480
  481 DKQGLGLSDD DNDEGNAKGK NKRKKRSENP LIKSNDFRDK NTKREQRVQL WYEKDVLQNI 540
  541 QSDDDEETYD LNNLAKEFKA KGVAVLGEST LTPDANEEVV QGKKAKRRAR HETATKDSSS 600
  601 ESSESEDDAN EDSDGEQPAA GTNAKKVRLS ENEMALGALL TRSKKTRRDL IDAAWNRYAF 660
  661 NDENVPVWFK LDEDEHMTKP TPVPKELTAE YQRKLQEVNV RPIKKVMEAK ARKHRRATKR 720
  721 LAKAKKMAEK IMENSDATNH EKSKQLKKVY KKAQEKKKEV TYVVAKKQTA ARRARRPAGV 780
  781 KGRYKVVDPR EKKDKRSMDA KKRREKGSKG RKGKGRK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..205] PSI-BLAST 79.0 RNA methyltransferase FtsJ
    2 View Details [206..681] PSI-BLAST 28.39794 Heavy meromyosin subfragment
    3 View Details [682..817] PSI-BLAST 4.39794 No description for 2dfsA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • methyltransferase activity
    		•  4.15445027778357 bayes_pls_golite062009
  • rRNA methyltransferase activity
    		•  4.09362182773099 bayes_pls_golite062009
  • N-methyltransferase activity
    		•  4.07806017452628 bayes_pls_golite062009
  • transferase activity, transferring one-carbon groups
    		•  4.07153733729662 bayes_pls_golite062009
  • protein methyltransferase activity
    		•  3.92746815303714 bayes_pls_golite062009
  • S-adenosylmethionine-dependent methyltransferase activity
    		•  3.39429041855776 bayes_pls_golite062009
  • RNA methyltransferase activity
    		•  3.07428840534971 bayes_pls_golite062009
  • histone methyltransferase activity
    		•  2.99461585647365 bayes_pls_golite062009
  • DNA-methyltransferase activity
    		•  2.43145108778901 bayes_pls_golite062009
  • protein-arginine N-methyltransferase activity
    		•  2.41876112831625 bayes_pls_golite062009
  • arginine N-methyltransferase activity
    		•  2.41876112831625 bayes_pls_golite062009
  • transferase activity
    		•  2.22303238506686 bayes_pls_golite062009
  • histone-arginine N-methyltransferase activity
    		•  2.04296107639729 bayes_pls_golite062009
  • rRNA (guanine) methyltransferase activity
    		•  2.00108769169811 bayes_pls_golite062009
  • rRNA (adenine) methyltransferase activity
    		•  1.83964463328968 bayes_pls_golite062009
  • tRNA methyltransferase activity
    		•  1.76571145896453 bayes_pls_golite062009
  • rRNA (adenine-N6,N6-)-dimethyltransferase activity
    		•  1.75675289134467 bayes_pls_golite062009
  • protein-arginine omega-N monomethyltransferase activity
    		•  1.66871163498737 bayes_pls_golite062009
  • catalytic activity
    		•  1.25333584501255 bayes_pls_golite062009
  • histone methyltransferase activity (H4-R3 specific)
    		•  1.1103522853299 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.914549843668268 bayes_pls_golite062009
  • rRNA (uridine-2'-O-)-methyltransferase activity
    		•  0.90544396691236 bayes_pls_golite062009
  • protein-arginine omega-N asymmetric methyltransferase activity
    		•  0.89325812193225 bayes_pls_golite062009
  • DNA binding
    		•  0.86027591375666 bayes_pls_golite062009
  • rRNA (uridine) methyltransferase activity
    		•  0.742142092552002 bayes_pls_golite062009
  • site-specific DNA-methyltransferase (adenine-specific) activity
    		•  0.703178429468566 bayes_pls_golite062009
  • tRNA (cytosine-5-)-methyltransferase activity
    		•  0.672282175551951 bayes_pls_golite062009
  • tRNA (cytosine)-methyltransferase activity
    		•  0.672282175551951 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.616949327277483 bayes_pls_golite062009
  • RNA binding
    		•  0.417524996559564 bayes_pls_golite062009
  • binding
    		•  0.383237930789959 bayes_pls_golite062009
  • O-methyltransferase activity
    		•  0.250946859465502 bayes_pls_golite062009
  • rRNA (guanine-N1-)-methyltransferase activity
    		•  0.234572322347698 bayes_pls_golite062009
  • tRNA (adenine-N1-)-methyltransferase activity
    		•  0.0803947886180681 bayes_pls_golite062009
  • tRNA (adenine)-methyltransferase activity
    		•  0.0803947886180681 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle