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Protein Overview: PGRP-LE-PA, FBpp...

General Information:
Name(s) found: FBpp0300347 [FlyBase]
PGRP-LE-PA / FBpp0073968 [FlyBase]
Description(s) found:
Found 32 descriptions.
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  • type=protein; loc=X:complement(15695284..15695643,15695716..15695780,15695996..15696109,15696173..15696472,15696542..15696740); ID=FBpp0300347; name=PGRP-LE-PB; parent=FBgn0030695,FBtr0307978; dbxref=FlyBase:FBpp0300347,FlyBase_Annotation_IDs:CG8995-PB,REFSEQ:NP_001245695,GB_protein:AFH07408; MD5=28dfdc70f19cbf361cd56b9a63b3ef4c; length=345; release=r5.56; species=Dmel; [FlyBase]
  • The gene Peptidoglycan recognition protein LE is referred to in FlyBase by the symbol Dmel\PGRP-LE (CG8995, FBgn0030695). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:15695185..15696958. It has the cytological map location 13F1. Based on sequence similarity, it is predicted to have molecular function</span>: peptidoglycan receptor activity. There is experimental evidence that it is involved in the biological process</span>: immune response; response to bacterium; defense response to Gram-positive bacterium; positive regulation of innate immune response. 5 alleles are reported. The phenotypes of these alleles are annotated with: adult cuticle; melanotic mass. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 345 amino acids

    Gene Ontology:
    Cellular Component: integral to plasma membrane [NAS]
    extracellular region [IDA][NAS]
    Biological Process: response to bacterium [IMP]
    immune response [IMP][ISS][TAS]
    positive regulation of innate immune response [IMP]
    signal transduction [TAS]
    peptidoglycan catabolic process [IEA]
    defense response [NAS]
    defense response to Gram-positive bacterium [IDA]
    Molecular Function: peptidoglycan receptor activity [ISS][NAS][TAS]
    peptidoglycan binding [NAS][TAS]
    protein binding [IEA]
    N-acetylmuramoyl-L-alanine amidase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSESGIKKLS QERTREWLAS QEDEELESIA ESSVVDSLDY DYTEEEEDAD QNTSEEISTM  60
   61 TLGTQIATKK HSIISDTIRD LMNSINSIQT LGNVNISNST NVHIGNVTNI NGNIQIIADG 120
  121 LTQNRRDRRH VSPPRDNAPK TPTHFEDDYQ DESEERVRSD VFIRRQKFKI PKELSAIIPR 180
  181 SSWLAQKPMD EPLPLQLPVK YVVILHTATE SSEKRAINVR LIRDMQCFHI ESRGWNDIAY 240
  241 NFLVGCDGNI YEGRGWKTVG AHTLGYNRIS LGISFIGCFM KELPTADALN MCRNLLARGV 300
  301 EDGHISTDYR LICHCQCNST ESPGRRLYEE IQTWPHFYNI EEEEQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..174] deduced N/A No confident structure predictions are available.
    2 View Details [175..345] PSI-BLAST 47.522879 Crystal structure of peptidoglycan recognition protein-LE in complex with tracheal cytotoxin (monomeric diaminopimelic acid-type peptidoglycan)


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle