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Protein Overview: FBpp0309304, FBp...

General Information:
Name(s) found: FBpp0309304 [FlyBase]
FBpp0304148 [FlyBase]
sog-PA / FBpp0073879 [FlyBase]
Description(s) found:
Found 38 descriptions.
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  • type=protein; loc=X:complement(15499199..15499399,15499522..15501839,15502007..15502066,15507251..15507383,15508830..15508939,15519463..15519757); ID=FBpp0309304; name=sog-PE; parent=FBgn0003463,FBtr0340346; dbxref=FlyBase:FBpp0309304,FlyBase_Annotation_IDs:CG9224-PE; MD5=08ef9faa0bb935ba26480871f5e808f7; length=1038; release=r5.56; species=Dmel; [FlyBase]
  • type=protein; loc=X:complement(15499199..15499399,15499522..15501839,15502007..15502066,15507251..15507383,15508830..15508939,15519463..15519757); ID=FBpp0304148; name=sog-PB; parent=FBgn0003463,FBtr0331760; dbxref=REFSEQ:NP_001259576,GB_protein:AGB95418,FlyBase:FBpp0304148,FlyBase_Annotation_IDs:CG9224-PB; MD5=08ef9faa0bb935ba26480871f5e808f7; length=1038; release=r5.56; species=Dmel; [FlyBase]
  • The gene short gastrulation is referred to in FlyBase by the symbol Dmel\sog (CG9224, FBgn0003463). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:15498603..15520573. It has the cytological map location 13E1. It is reported to have molecular function</span>: growth factor activity. There is experimental evidence that it is involved in the biological process</span>: torso signaling pathway; terminal region determination; ring gland development; imaginal disc-derived wing vein morphogenesis; maternal specification of dorsal/ventral axis, oocyte, soma encoded. 104 alleles are reported. The phenotypes of these alleles are annotated with 33 unique terms, many of which group under: adult segment; organ system; adult mesothoracic segment; embryonic nervous system; peripheral nervous system; primordium; embryonic/larval tracheal system; thoracic segment; embryonic peripheral nervous system; extended germ band embryo. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1038 amino acids

    Gene Ontology:
    Cellular Component: integral to membrane [NAS]
    plasma membrane [ISS][NAS]
    Biological Process: torso signaling pathway [IGI]
    terminal region determination [IGI]
    ring gland development [IMP]
    BMP signaling pathway [NAS]
    amnioserosa formation [TAS]
    imaginal disc-derived wing vein morphogenesis [IMP]
    ectoderm development [NAS][TAS]
    zygotic determination of anterior/posterior axis, embryo [NAS]
    regulation of BMP signaling pathway [TAS]
    negative regulation of transforming growth factor beta receptor signaling pathway [NAS][TAS]
    maternal specification of dorsal/ventral axis, oocyte, soma encoded [IMP]
    positive regulation of transforming growth factor beta receptor signaling pathway [TAS]
    Molecular Function: growth factor activity [NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MANKLRKSNA IEWATATGTV PLLERSCCHS EDAALEPQAS KTSHREQAPI LRHLSQLSHL  60
   61 LIIAGLLIVC LAGVTEGRRH APLMFEESDT GRRSNRPAVT ECQFGKVLRE LGSTWYADLG 120
  121 PPFGVMYCIK CECVAIPKKR RIVARVQCRN IKNECPPAKC DDPISLPGKC CKTCPGDRND 180
  181 TDVALDVPVP NEEEERNMKH YAALLTGRTS YFLKGEEMKS MYTTYNPQNV VATARFLFHK 240
  241 KNLYYSFYTS SRIGRPRAIQ FVDDAGVILE EHQLETTLAG TLSVYQNATG KICGVWRRVP 300
  301 RDYKRILRDD RLHVVLLWGN KQQAELALAG KVAKYTALQT ELFSSLLEAP LPDGKTDPQL 360
  361 AGAGGTAIVS TSSGAASSMH LTLVFNGVFG AEEYADAALS VKIELAERKE VIFDEIPRVR 420
  421 KPSAEINVLE LSSPISIQNL RLMSRGKLLL TVESKKYPHL RIQGHIVTRA SCEIFQTLLA 480
  481 PHSAESSTKS SGLAWVYLNT DGSLAYNIET EHVNTRDRPN ISLIEEQGKR KAKLEDLTPS 540
  541 FNFNQAIGSV EKLGPKVLES LYAGELGVNV ATEHETSLIR GRLVPRPVAD ARDSAEPILL 600
  601 KRQEHTDAQN PHAVGMAWMS IDNECNLHYE VTLNGVPAQD LQLYLEEKPI EAIGAPVTRK 660
  661 LLEEFNGSYL EGFFLSMPSA ELIKLEMSVC YLEVHSKHSK QLLLRGKLKS TKVPGHCFPV 720
  721 YTDNNVPVPG DHNDNHLVNG ETKCFHSGRF YNESEQWRSA QDSCQMCACL RGQSSCEVIK 780
  781 CPALKCKSTE QLLQRDGECC PSCVPKKEAA DYSAQSSPAT NATDLLQQRR GCRLGEQFHP 840
  841 AGASWHPFLP PNGFDTCTTC SCDPLTLEIR CPRLVCPPLQ CSEKLAYRPD KKACCKICPE 900
  901 GKQSSSNGHK TTPNNPNVLQ DQAMQRSPSH SAEEVLANGG CKVVNKVYEN GQEWHPILMS 960
  961 HGEQKCIKCR CKDSKVNCDR KRCSRSTCQQ QTRVTSKRRL FEKPDAAAPA IDECCSTQCR1020
 1021 RSRRHHKRQP HHQQRSSS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..92] deduced N/A No confident structure predictions are available.
    2 View Details [93..177] FFAS03 2.22 Structure of a Chordin-like Cysteine-rich Repeat (VWC module) from Collagen IIA
    3 View Details [178..279] deduced N/A No confident structure predictions are available.
    4 View Details [280..482] deduced N/A No confident structure predictions are available.
    5 View Details [483..637] deduced N/A No confident structure predictions are available.
    6 View Details [638..1038] PSI-BLAST 17.221849 Low density lipoprotein (LDL) receptor YWTD domain; Low density lipoprotein (LDL) receptor, different EGF domains; Ligand-binding domain of low-density lipoprotein receptor

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • extracellular matrix structural constituent
    		•  4.15933718640855 bayes_pls_golite062009
  • platelet-derived growth factor binding
    		•  3.82504499599732 bayes_pls_golite062009
  • growth factor binding
    		•  3.07979418958893 bayes_pls_golite062009
  • protein binding
    		•  2.13859012595807 bayes_pls_golite062009
  • binding
    		•  1.72922707266313 bayes_pls_golite062009
  • SMAD binding
    		•  1.58863880004415 bayes_pls_golite062009
  • receptor binding
    		•  1.47786086313432 bayes_pls_golite062009
  • integrin binding
    		•  1.24144638872639 bayes_pls_golite062009
  • extracellular matrix structural constituent conferring tensile strength
    		•  0.493781546820044 bayes_pls_golite062009
  • protein complex binding
    		•  0.438148656492799 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6
    Term Confidence Notes
  • receptor binding
    		•  4.33045214660893 bayes_pls_golite062009
  • growth factor activity
    		•  3.53240291240997 bayes_pls_golite062009
  • epidermal growth factor receptor binding
    		•  3.23778562911102 bayes_pls_golite062009
  • protein binding
    		•  3.02592228806142 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  2.86713236325679 bayes_pls_golite062009
  • ErbB-2 class receptor binding
    		•  2.56367101923009 bayes_pls_golite062009
  • heparin binding
    		•  2.49012176521764 bayes_pls_golite062009
  • binding
    		•  2.33940742543305 bayes_pls_golite062009
  • ErbB-3 class receptor binding
    		•  2.197145317433 bayes_pls_golite062009
  • pattern binding
    		•  1.7855850180475 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.66401431847753 bayes_pls_golite062009
  • signal transducer activity
    		•  1.66401431847753 bayes_pls_golite062009
  • polysaccharide binding
    		•  1.52943230565474 bayes_pls_golite062009
  • extracellular matrix structural constituent
    		•  0.87690248187077 bayes_pls_golite062009
  • transcription factor binding
    		•  0.795087651578297 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  0.44857826904729 bayes_pls_golite062009
  • carbohydrate binding
    		•  0.37481112933019 bayes_pls_golite062009
  • glycoprotein binding
    		•  0.128291636237359 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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