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Protein Overview: HDAC6-PC

General Information:
Name(s) found: HDAC6-PC / FBpp0073826 [FlyBase]
Description(s) found:
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  • gi|24642146|ref|NP_727843.1| HDAC6, isoform C [Drosophila melanogaster] [NCBI NR]
  • gi|22833161|gb|AAN09662.1| HDAC6, isoform C [Drosophila melanogaster] [NCBI NR]
  • gi|225579967|gb|ACN94227.1| histone deacetylase 6 isoform C [Drosophila melanogaster] [NCBI NR]
  • gi|225579949|gb|ACN94211.1| histone deacetylase 6 isoform C [Drosophila melanogaster] [NCBI NR]
  • gi|225579931|gb|ACN94195.1| histone deacetylase 6 isoform C [Drosophila melanogaster] [NCBI NR]
  • gi|225579922|gb|ACN94187.1| histone deacetylase 6 isoform C [Drosophila melanogaster] [NCBI NR]
  • gi|225579904|gb|ACN94171.1| histone deacetylase 6 isoform C [Drosophila melanogaster] [NCBI NR]
  • gi|225579895|gb|ACN94163.1| histone deacetylase 6 isoform C [Drosophila melanogaster] [NCBI NR]
  • gi|225579886|gb|ACN94155.1| histone deacetylase 6 isoform C [Drosophila melanogaster] [NCBI NR]
  • gi|225579877|gb|ACN94147.1| histone deacetylase 6 isoform C [Drosophila melanogaster] [NCBI NR]
  • gi|225579868|gb|ACN94139.1| histone deacetylase 6 isoform C [Drosophila melanogaster] [NCBI NR]
  • gi|225579859|gb|ACN94131.1| histone deacetylase 6 isoform C [Drosophila melanogaster] [NCBI NR]
  • gi|225579841|gb|ACN94115.1| histone deacetylase 6 isoform C [Drosophila melanogaster] [NCBI NR]
  • gi|225579805|gb|ACN94083.1| histone deacetylase 6 isoform C [Drosophila melanogaster] [NCBI NR]
  • gi|225579796|gb|ACN94075.1| histone deacetylase 6 isoform C [Drosophila melanogaster] [NCBI NR]
  • gi|225579778|gb|ACN94059.1| histone deacetylase 6 isoform C [Drosophila melanogaster] [NCBI NR]
  • gi|225579769|gb|ACN94051.1| histone deacetylase 6 isoform C [Drosophila melanogaster] [NCBI NR]
  • The gene HDAC6 is referred to in FlyBase by the symbol Dmel\HDAC6 (CG6170, FBgn0026428). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:15226988..15234394. It has the cytological map location 13B6. There is experimental evidence that it has the molecular function</span>: histone deacetylase activity. There is experimental evidence that it is involved in the biological process</span>: histone deacetylation; regulation of transcription. 10 alleles are reported. No phenotypic data is available. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
  • >CG6170-PC translation from_gene[CG6170 HDAC6 FBgn0026428] seq_release:3 mol_weight=126007 cds_boundaries:(X:15,065,971..15,071,026[+]) aa_length:1138 transcript_info:[CG6170-RC seq_release:3] gene_info:[gene symbol:HDAC6 FBgn0026428 gene_boundaries:(X [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q8IR37) CG6170-PC [DrosMelano7227.FASTAC.txt]
  • CG6170-PC, isoform C [Drosophila melanogaster]gi|24642146|ref|NP_727843.1| CG6170-PC [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=X:join(15228990..15229301,15229383..15229513,15229579..15229762,15230323..15230594,15230648..15232055,15232105..15232737,15232870..15232957,15233660..15234048); ID=FBpp0073826; name=HDAC6-PC; parent=FBgn0026428,FBtr0074009; dbxref=FlyBas [fly-100309-contam.fasta]
  • HDAC6 CG6170-PC, isoform C [Drosophila melanogaster] [nr-271106-contam.fasta]
  • CG6170-PC, isoform C [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=X:join(15228990..15229301,15229383..15229513,15229579..15229762,15230323..15230594,15230648..15232055,15232105..15232737,15232870..15232957,15233660..15234048); ID=FBpp0073826; name=HDAC6-PC; parent=FBgn0026428,FBtr0074009; dbxref=FlyBase:FBpp0073826,FlyBase_Annotation_IDs:CG6170-PC,GB_protein:AAN09662.1,REFSEQ:NP_727843,GB_protein:AAN09662; MD5=ae81cddd11690434834904d16b699767; length=1138; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=X:join(15228990..15229301,15229383..15229513,15229579..15229762,15230323..15230594,15230648..15232055,15232105..15232737,15232870..15232957,15233660..15234048); ID=FBpp0073826; name=HDAC6-PC; parent=FBgn0026428,FBtr0074009; dbxref=FlyBase:FBpp0073826,FlyBase_Annotation_IDs:CG6170-PC,GB_protein:AAN09662.1,REFSEQ:NP_727843,GB_protein:AAN09662; MD5=ae81cddd11690434834904d16b699767; length=1138; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • HDAC6, isoform C OS=Drosophila melanogaster GN=HDAC6 PE=2 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=X:join(15228990..15229301,15229383..15229513,15229579..15229762,15230323..15230594,15230648..15232055,15232105..15232737,15232870..15232957,15233660..15234048); ID=FBpp0073826; name=HDAC6-PC; parent=FBgn0026428,FBtr0074009; dbxref=FlyBase:FBpp0073826,FlyBase_Annotation_IDs:CG6170-PC,GB_protein:AAN09662.1,REFSEQ:NP_727843,GB_protein:AAN09662,FlyMine:FBpp0073826,modMine:FBpp0073826; MD5=ae81cddd11690434834904d16b699767; length=1138; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=X:join(15334957..15335268,15335350..15335480,15335546..15335729,15336290..15336561,15336615..15338022,15338072..15338704,15338837..15338924,15339627..15340015); ID=FBpp0073826; name=HDAC6-PC; parent=FBgn0026428,FBtr0074009; dbxref=FlyBase:FBpp0073826,FlyBase_Annotation_IDs:CG6170-PC,GB_protein:AAN09662.1,REFSEQ:NP_727843,GB_protein:AAN09662,FlyMine:FBpp0073826,modMine:FBpp0073826; MD5=ae81cddd11690434834904d16b699767; length=1138; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=X:join(15334957..15335268,15335350..15335480,15335546..15335729,15336290..15336561,15336615..15338022,15338072..15338704,15338837..15338924,15339627..15340015); ID=FBpp0073826; name=HDAC6-PC; parent=FBgn0026428,FBtr0074009; dbxref=FlyBase:FBpp0073826,FlyBase_Annotation_IDs:CG6170-PC,GB_protein:AAN09662.1,REFSEQ:NP_727843,GB_protein:AAN09662,FlyMine:FBpp0073826,modMine:FBpp0073826; MD5=ae81cddd11690434834904d16b699767; length=1138; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • Isoform of M9PJN5, Histone deacetylase 6 isoform C OS=Drosophila melanogaster GN=HDAC6 PE=1 SV=1 [DROME.fasta.20160308]
  • FBpp0073826 type=protein; loc=X:join(15334957..15335268,15335350..15335480,15335546..15335729,15336290..15336561,15336615..15338022,15338072..15338704,15338837..15338924,15339627..15340015); ID=FBpp0073826; name=HDAC6-PC; parent=FBgn0026428,FBtr0074009; dbxref=FlyBase:FBpp0073826,FlyBase_Annotation_IDs:CG6170-PC,GB_protein:AAN09662.1,REFSEQ:NP_727843,GB_protein:AAN09662,FlyMine:FBpp0073826,modMine:FBpp0073826; MD5=ae81cddd11690434834904d16b699767; length=1138; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=X:join(15334957..15335268,15335350..15335480,15335546..15335729,15336290..15336561,15336615..15338022,15338072..15338704,15338837..15338924,15339627..15340015); ID=FBpp0073826; name=HDAC6-PC; parent=FBgn0026428,FBtr0074009; dbxref=FlyBase:FBpp0073826,FlyBase_Annotation_IDs:CG6170-PC,GB_protein:AAN09662.1,REFSEQ:NP_727843,GB_protein:AAN09662,UniProt/TrEMBL:Q8IR37,FlyMine:FBpp0073826,modMine:FBpp0073826; MD5=ae81cddd11690434834904d16b699767; length=1138; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 1138 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDA]
    Biological Process: histone deacetylation [IDA]
    regulation of transcription [IDA]
    Molecular Function: zinc ion binding [IEA]
    histone deacetylase activity [IDA][ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLTKDLNSFS QSPPIVTRRS AQQAKIQTRA MASKSKTGTT GAATAAGGTG SSSGSISGGF  60
   61 NAADPRKSNK PNAALLEAKR RARNNMLKNQ GCGSQESVTD IFQNAVNSKS LVRKPTALIY 120
  121 DESMSQHCCL WDKEHYECPE RFTRVLERCR ELNLTERCLE LPSRSATKDE ILRLHTEEHF 180
  181 ERLKETSGIR DDERMEELSS RYDSIYIHPS TFELSLLASG STIELVDHLV AGKAQNGMAI 240
  241 IRPPGHHAMK AEYNGYCFFN NVALATQHAL DVHKLQRILI IDYDVHHGQG TQRFFYNDPR 300
  301 VVYFSIHRFE HGSFWPHLHE SDYHAIGSGA GTGYNFNVPL NATGMTNGDY LAIFQQLLLP 360
  361 VALEFQPELI IVSAGYDAAL GCPEGEMEVT PACYPHLLNP LLRLADARVA VVLEGGYCLD 420
  421 SLAEGAALTL RSLLGDPCPP LVETVPLPRA ELAQALLSCI AVHRPHWRCL QLQQTYDCVE 480
  481 LQDRDKEEDL HTVLRHWIGG PPPMDRYPTR DTAIPLPPEK LTSNAARLQV LRAETKLSVP 540
  541 SFKVCYAYDA QMLLHCNLND TGHPEQPSRI QHIHKMHDDY GLLKQMKQLS PRAATTDEVC 600
  601 LAHTRAHVNT VRRLLGREPK ELHDAAGIYN SVYLHPRTFD CATLAAGLVL QAVDSVLRGE 660
  661 SRSGICNVRP PGHHAEQDHP HGFCIFNNVA IAAQYAIRDF GLERVLIVDW DVHHGNGTQH 720
  721 IFESNPKVLY ISLHRYEHGS FFPKGPDGNF DVVGKGAGRG FNVNIPWNKK GMGDLEYALA 780
  781 FQQLIMPIAY EFNPQLVLVS AGFDAAIGDP LGGCKVTAEG YGMLTHWLSA LASGRIIVCL 840
  841 EGGYNVNSIS YAMTMCTKTL LGDPVPTPQL GATALQKPPT VAFQSCVESL QQCLQVQRNH 900
  901 WRSLEFVGRR LPRDPVVGEN NNEDFLTASL RHLNISNDDA TAAAGGLAGD RPDCGDERPS 960
  961 GSKPKVKVKT LSDYLAENKE ALEQSEMFAV YPLKTCPHLR LLRPEEAPRS LDSGAECSVC1020
 1021 GSTGENWVCL SCRHVACGRY VNAHMEQHSV EEQHPLAMST ADLSVWCYAC SAYVDHPRLY1080
 1081 AYLNPLHEDK FQEPMAWTHG CAWREDGCYA TGPDGRDEDD DDDNGAGSSI CLRLERNN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..96] deduced N/A No confident structure predictions are available.
    2 View Details [97..499] PSI-BLAST 107.0 No description for 2nvrA was found.
    3 View Details [500..954] FFAS03 8.56 No description for 2nvrA was found.
    4 View Details [955..1138] PSI-BLAST 22.69897 No description for 2g43A was found.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.81

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle