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Protein Overview: CG5599-PA

General Information:
Name(s) found: CG5599-PA / FBpp0073781 [FlyBase]
Description(s) found:
Found 21 descriptions.
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  • This gene is referred to in FlyBase by the symbol Dmel\CG5599 (CG5599, FBgn0030612). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:14980171..14982665. It has the cytological map location 13A10. Based on sequence similarity, it is predicted to have molecular function</span>: dihydrolipoamide branched chain acyltransferase activity. There is experimental evidence that it is involved in the biological process</span>: phagocytosis, engulfment. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 462 amino acids

    Gene Ontology:
    Cellular Component: mitochondrial oxoglutarate dehydrogenase complex [ISS]
    Biological Process: fatty-acyl-CoA biosynthetic process [IEA]
    phagocytosis, engulfment [IMP]
    tricarboxylic acid cycle [ISS]
    Molecular Function: protein binding [IEA]
    cofactor binding [IEA]
    dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity [IEA]
    dihydrolipoamide branched chain acyltransferase activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATHLLRNGA TCWLLRNCIS QRAALRRCLH VTSSLDKTVS FNLSDIGEGI REVTVKEWFV  60
   61 KEGDTVEQFD NLCEVQSDKA SVTITSRYDG KITKIHHKID EIALVGKPLL DFDVVNEDED 120
  121 EPEDSSSSSS STSSDSSASE NEEKQSAEAS ATPTEGRVII PATPSVRRLA KEHQLDLAKV 180
  181 PATGKNGRVL KGDILEFLGQ VPPGTNVPHP TLLAKTPSAA PSGAASVSVP ADRVEVLKGV 240
  241 RKAMLKSMTE SLKIPHFAYS DEIDMTQLMQ FRNQLQLVAK ENGVPKLTFM PFCIKAASIA 300
  301 LSKYPIVNSS LDLASESLVF KGAHNISVAI DTPQGLVVPN IKNCQTKTII EIAKDLNALV 360
  361 ERGRTGSLSP ADFADGTFSL SNIGVIGGTY THPCIMAPQV AIGAMGRTKA VPRFNDKDEV 420
  421 VKAYVMSVSW SADHRVIDGV TMASFSNVWK QYLENPALFL LH

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..113] PSI-BLAST 19.522879 Lipoyl domain of the mitochondrial branched-chain alpha-ketoacid dehydrogenase
    2 View Details [114..212] FFAS03 3.33 The crystal structure of dihydrolipoamide dehydrogenase and dihydrolipoamide dehydrogenase-binding protein (didomain) subcomplex of human pyruvate dehydrogenase complex.
    3 View Details [213..462] PSI-BLAST 77.09691 No description for 2ihwA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • dihydrolipoyllysine-residue acetyltransferase activity
    		•  7.74877411346968 bayes_pls_golite062009
  • S-acetyltransferase activity
    		•  7.59642806209362 bayes_pls_golite062009
  • dihydrolipoamide S-acyltransferase activity
    		•  7.45508609960612 bayes_pls_golite062009
  • pyruvate dehydrogenase activity
    		•  7.05950875585975 bayes_pls_golite062009
  • S-acyltransferase activity
    		•  5.24395351180663 bayes_pls_golite062009
  • acetyltransferase activity
    		•  3.55333192628786 bayes_pls_golite062009
  • acetyl-CoA carboxylase activity
    		•  3.31123635155865 bayes_pls_golite062009
  • transferase activity, transferring acyl groups other than amino-acyl groups
    		•  2.83081843426182 bayes_pls_golite062009
  • CoA carboxylase activity
    		•  2.82233689048595 bayes_pls_golite062009
  • acyltransferase activity
    		•  2.79754636323803 bayes_pls_golite062009
  • ligase activity, forming carbon-carbon bonds
    		•  2.53708026587542 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors
    		•  2.22092493760605 bayes_pls_golite062009
  • catalytic activity
    		•  1.39099902011318 bayes_pls_golite062009
  • binding
    		•  0.988780943163898 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  0.629490807878017 bayes_pls_golite062009
  • ligase activity
    		•  0.56894584941056 bayes_pls_golite062009
  • aminomethyltransferase activity
    		•  0.377624262164477 bayes_pls_golite062009
  • protein binding
    		•  0.273657523907432 bayes_pls_golite062009
  • glycine dehydrogenase (decarboxylating) activity
    		•  0.0222922933292004 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor
    		•  0.0222922933292004 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.66

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle