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Protein Overview: CG2543-PA

General Information:
Name(s) found: CG2543-PA / FBpp0073488 [FlyBase]
Description(s) found:
Found 19 descriptions.
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  • This gene is referred to in FlyBase by the symbol Dmel\CG2543 (CG2543, FBgn0030407). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:12505947..12509563. It has the cytological map location 11B3-11B4. Based on sequence similarity, it is predicted to have molecular function</span>: tetrahydrofolylpolyglutamate synthase activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: tetrahydrofolylpolyglutamate biosynthetic process. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 572 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [ISS]
    mitochondrion [ISS]
    Biological Process: tetrahydrofolylpolyglutamate biosynthetic process [ISS]
    Molecular Function: tetrahydrofolylpolyglutamate synthase activity [ISS]
    ATP binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAACLLRYLV RQSRKPRSLV VSRESSHCSR MSTYSTVTNL STVKMQRIQH LAAFRSGVSL  60
   61 AERVLNPPQQ SINGNHVSGN IQCSSDNNNK DTNAAFELAI KQLNSLQSND AAIRNSMSNS 120
  121 RVDTKADTIK YLERSGLPLE TVEQLSFIHV AGTKGKGSTC ALTESLLRHQ GFRTGFFSSP 180
  181 HILFTNERIR IDGQLLSKDK FTEQFWKVYN RLWDLREHDH DMPAYFKFLT ILGFHVFVAE 240
  241 NVDVVVLEVG IGGEHDCTNI VRNVRTVGIT SLGLEHTELL GRTLPEIAWQ KAGIIKTGSH 300
  301 VFTHVTQPEC LEVIRQRTKE HSATLYEVPP TEDYFRSKAY APIWQTFSNL IRLNGSLAIQ 360
  361 LAQDWLSQSG KQQHTPNEVK MDPQLLDGLI STHWPGRCQL IEWHGMRLHL DGAHTLESME 420
  421 VCTDWFEKNV RDSVNPKILI FNRTGESGFA PLLKLLNRTC DFDMVCFVPN LATSTPNAPS 480
  481 QVMVRFSPEM QLNRARIIAS AWSDLCATEQ KKDVGQVYNT LTDAFTAIRQ RFPQATDNEG 540
  541 QLEVLVTGSI HLLGAAISAL DLIDDPKSRT DK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..93] deduced N/A No confident structure predictions are available.
    2 View Details [94..572] PSI-BLAST 74.39794 E.coli FolC in complex with DHPP and ADP


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.91

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle