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Protein Overview: Ir8a-PA

General Information:
Name(s) found: Ir8a-PA / FBpp0071268 [FlyBase]
Description(s) found:
Found 19 descriptions.
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  • The gene Ionotropic receptor 8a is referred to in FlyBase by the symbol Dmel\Ir8a (CG32704, FBgn0052704). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:9126759..9130618. It has the cytological map location 8D2. Based on sequence similarity, it is predicted to have molecular function</span>: kainate selective glutamate receptor activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: ion transport. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 936 amino acids

    Gene Ontology:
    Cellular Component: membrane [ISS]
    Biological Process: ion transport [IEA]
    Molecular Function: kainate selective glutamate receptor activity [ISS]
    extracellular-glutamate-gated ion channel activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MELPLLVLLL ALRFAGSEVL KITFWIEPVQ RAEFDTDIAM VLKELDALRL DVKVDDTTLT  60
   61 LTRSEDGLDM QRFCEILSTV GASAVIDLTY SHWEEGYNLV RSLGIGYVRL ERIMRPFLDM 120
  121 FGDFMRQKRA NNVAMVFMNA RDAVEAMQQM LVGYPFRTLI MDASQTDPGQ HFLERIRSLR 180
  181 PAPTYIALFA RAAAMNGIFE KVQKADLFQR PLEWHFVFLD TRDRVFKYRR QAELCTRFTL 240
  241 NPRAICRSMP MPDLYCGSGF TMQRAMLLNV LRSLINAAQV SPGYPLAIYQ DCNATASSSE 300
  301 VSDPLEKDDY NWLDMVHWSN FLAYAPPLPH IQDQFQSPVP GLTFAVNISA GYYSSEHEAK 360
  361 TDLAAWSSVG EMRLLNETIS PARRFFRIGT AESIPWSYLR REEGTGELIR DRSGLPIWEG 420
  421 YCIDFIIRLS QKLNFEFEIV APEVGHMGEL NELGEWDGVV GDLVRGETDF AIAALKMYSE 480
  481 REEVIDFLPP YYEQTGISIA IRKPVRRTSL FKFMTVLRLE VWLSIVAALV GTAIMIWFMD 540
  541 KYSPYSSRNN RQAYPYACRE FTLRESFWFA LTSFTPQGGG EAPKAISGRM LVAAYWLFVV 600
  601 LMLATFTANL AAFLTVERMQ TPVQSLEQLA RQSRINYTVV KDSDTHQYFV NMKFAEDTLY 660
  661 RMWKELALNA SKDFKKFRIW DYPIKEQYGH ILLAINSSQP VADAKEGFAN VDAHENADYA 720
  721 FIHDSAEIKY EITRNCNLTE VGEVFAEQPY AVAVQQGSHL GDELSYAILE LQKDRFFEEL 780
  781 KAKYWNQSNL PNCPLSEDQE GITLESLGGV FIATLFGLVL AMMTLGMEVL YYKKKQNALE 840
  841 ITQVRPVNDS SGSGGNSSTA PPTATSTTKQ AWHIPVLEAE EKPAKVSPPP SFETATFRGK 900
  901 KLPARITLGD GKFKPRHGLY ARRNLGASDS HSGYME

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..453] PSI-BLAST 35.522879 No description for 2e4uA was found.
    2 View Details [454..578] PSI-BLAST 4.522879 Crystal Structure of Cysteine-Binding Protein from Campylobacter jejuni at 2.0 A Resolution
    3 View Details [579..848] PSI-BLAST 27.221849 Structure of the Kainate Receptor Subunit GluR6 Agonist Binding Domain Complexed with Domoic Acid
    4 View Details [849..936] MSA 1.153994 View MSA. No confident structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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