Protein Overview: su(r)-PC

General Information:
Name(s) found:	su(r)-PC / FBpp0071273 [FlyBase]
Description(s) found: Found 32 descriptions. SHOW ALL	The gene suppressor of rudimentary is referred to in FlyBase by the symbol Dmel\su(r) (CG2194, FBgn0086450). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:9090839..9096770. It has the cytological map location 8D1. Based on sequence similarity, it is predicted to have molecular function</span>: dihydropyrimidine dehydrogenase (NADP+) activity. There is experimental evidence that it is involved in the biological process</span>: 'de novo' pyrimidine base biosynthetic process. 19 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
Organism:	Drosophila melanogaster
Length:	1031 amino acids
Gene Ontology:
Cellular Component:	cytoplasm [IEA]
Biological Process:	'de novo' pyrimidine base biosynthetic process [IGI] UMP biosynthetic process [IEA] oxidation reduction [IEA]
Molecular Function:	electron carrier activity [IEA] dihydropyrimidine dehydrogenase (NADP+) activity [ISS][NAS] iron-sulfur cluster binding [IEA] dihydrouracil dehydrogenase (NAD+) activity [TAS] dihydroorotate oxidase activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSPPQLLSKD SPDIEDLLSL NPRVKTQCSV VPTKQTKENK KHWKRNADHA APPCTTLAND  60
   61 FSDIKHTTLS ERGALEEAAR CLKCADAPCQ KSCPTQLDIK SFITSIANKN FYGAAKAIFS 120
  121 DNPLGLTCGM VCPTSDLCVG GCNLQASEAG PINIGGLQQF ATEVFKKMGV RQRRTPQAEA 180
  181 NPLSQKIALV GGGPASLSCA TFLARLGYRD VTIYERRSYL GGLSAAEIPQ YRLPIDAVNF 240
  241 EIDLVRDLGV RIETGRSLGT KDLTIQGLLS TGHDAVFVGI GLPEPKLNPI FAGLQPSNGF 300
  301 YTSKNFLPLV SDGSKPGLCA CKAAAGLPKL HGNVIVLGAG DTAFDCATSA LRCGARRVFV 360
  361 VFRKGSSGIR AVPEEVELAR DERCELLPYL SPRKVIVKDG LITAMEFCRT EQNENDEWVE 420
  421 DEEQTQRLKA NFVISAFGSG LEDQDVKAAL APLQFRGELP VVDRVTMQSS VKQVFLGGDL 480
  481 AGVANTTVES VNDGKVAAWS IHCQLQGLPL DTPAALPLFY TDIDAVDISV EMCGIRFENP 540
  541 FGLASAPPTT STAMIRRAFE QGWGFVVTKT FGLDKDLVTN VSPRIVRGTT SGYKYGPQQG 600
  601 CFLNIELISE KRAEYWLKSI GELKRDFPEK IVIASIMCSF NEEDWTELAI KAEQSGADAL 660
  661 ELNLSCPHGM GERGMGLACG QDPELVEQIS RWVRKAVKLP FFIKLTPNIT DIVSIAAAAK 720
  721 RGGADGGSAI NTVQGLMGLK ADSTAWPAIG KEQRTTYGGV SGNATRPMAL KAISDIANRV 780
  781 PGFPILGIGG IDSGEVALQF IHAGATVLQI CSSVQNQDFT VIEDYCTALK ALLYLKANPP 840
  841 PVDGPFWDGQ SPPTPVHQKG KPVVRLTGEG KATLGFFGPY QRQRDIKMAE LRSQKGALWD 900
  901 AEQVKATPPA SNGAPNPAPR IKDVIGAALD KIGSYNKLDN KQQKVALIDD DMCINCGKCY 960
  961 MTCADSGYQA IEFDKDTHIP HVNDDCTGCT LCVSVCPIID CITMVPKKIP HVIKRGVEEK1020
 1021 IFYTHALSQC Q

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Searching the YRC Public Image Repository, found results:

Currently showing to of results.

[View Search in the YRC Public Image Repository]

Searching the YRC Public Image Repository, found no results.

Ginzu Version Information

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Gene Ontology predictions

Term	Confidence	Notes
glutamate synthase activity	8.25305391467034	bayes_pls_golite062009
glutamate synthase activity, NADH or NADPH as acceptor	8.23578981764913	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor	7.02480361242491	bayes_pls_golite062009
glutamate synthase (NADPH) activity	6.79992270958953	bayes_pls_golite062009
dihydropyrimidine dehydrogenase (NADP+) activity	4.09148795322957	bayes_pls_golite062009
pyrimidine binding	2.91784612612513	bayes_pls_golite062009
uracil binding	2.91784612612513	bayes_pls_golite062009
dihydroorotate dehydrogenase activity	2.73800716363956	bayes_pls_golite062009
dihydrouracil dehydrogenase (NAD+) activity	2.66245762632422	bayes_pls_golite062009
dihydroorotate oxidase activity	2.35584458985229	bayes_pls_golite062009
oxidoreductase activity	1.79641444157516	bayes_pls_golite062009
catalytic activity	1.56773888754354	bayes_pls_golite062009
antioxidant activity	1.31666452665754	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors	0.985549379433495	bayes_pls_golite062009
electron carrier activity	0.868432848212603	bayes_pls_golite062009
aspartate oxidase activity	0.672303476807686	bayes_pls_golite062009
nucleobase binding	0.450556835399301	bayes_pls_golite062009
coenzyme binding	0.424849261981	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	0.310048858653841	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor	0.27791247084103	bayes_pls_golite062009
succinate dehydrogenase (ubiquinone) activity	0.27791247084103	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor	0.242456601435627	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	0.229465315580407	bayes_pls_golite062009
binding	0.228983691415463	bayes_pls_golite062009

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.97

Source: Reynolds et al. (2008)

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..1031]	PSI-BLAST	1000.0	Dihydropyrimidine dehydrogenase, N-terminal domain; Dihydropyrimidine dehydrogenase, domain 4; Dihydropyrimidine dehydrogenase, domain 3; Dihydropyrimidine dehydrogenase, domain 2; Dihydropyrimidine dehydrogenase, C-terminal domain

Protein Overview: su(r)-PC

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: