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Protein Overview: HP1b-PB, FBpp030...

General Information:
Name(s) found: FBpp0301605 [FlyBase]
HP1b-PB / FBpp0291019 [FlyBase]
HP1b-PA / FBpp0071221 [FlyBase]
Description(s) found:
Found 32 descriptions.
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  • type=protein; loc=X:8975392..8976114; ID=FBpp0301605; name=HP1b-PC; parent=FBgn0030082,FBtr0309871; dbxref=FlyBase:FBpp0301605,FlyBase_Annotation_IDs:CG7041-PC,REFSEQ:NP_001245586,GB_protein:AFH07300; MD5=3af2075f2419d9ef812ab878ade34a78; length=240; release=r5.56; species=Dmel; [FlyBase]
  • The gene HP1b is referred to in FlyBase by the symbol Dmel\HP1b (CG7041, FBgn0030082). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:8975096..8976391. It has the cytological map location 8C4. Based on sequence similarity, it is predicted to have molecular function</span>: chromatin binding. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: chromatin assembly or disassembly. 4 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
  • The gene HP1b is referred to in FlyBase by the symbol Dmel\HP1b (CG7041, FBgn0030082). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:8975096..8976391. It has the cytological map location 8C4. Based on sequence similarity, it is predicted to have molecular function</span>: chromatin binding. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: chromatin assembly or disassembly. 4 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 240 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEA]
    chromatin [IEA]
    Biological Process: chromatin assembly or disassembly [IEA]
    Molecular Function: chromatin binding [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAEFSVERVE DKRTVNGRTE YYLKWKGYPR SENTWEPVEN LDCPDLIANF EESLKNNKKE  60
   61 TKKRLSTSST PESIRSKRKS FLEDDTEEQK KLIGFERGLE ASKILGATDS SGHLMFLMKW 120
  121 KGSDHADLVP AKLANTRCPQ VVIQFYEERL TWHTGSGNGN GNTNSVNLGS SGGLGSVGGS 180
  181 GAGDDTAPGS VGTTGGGSNI DGGDEEDPEP ASPIGSINQD ENIKPDESSE LDNGQPDADD 240
  241

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..69] PSI-BLAST 13.522879 Heterochromatin protein 1, HP1
    2 View Details [70..178] PSI-BLAST 20.522879 HP1 chromo shadow domain in complex with PXVXL motif of CAF-1
    3 View Details [179..240] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription repressor activity
    		•  4.08500855631983 bayes_pls_golite062009
  • transcription regulator activity
    		•  3.64390820819794 bayes_pls_golite062009
  • methylated histone residue binding
    		•  3.42338304360938 bayes_pls_golite062009
  • chromatin binding
    		•  3.1924157640698 bayes_pls_golite062009
  • binding
    		•  3.06758476214113 bayes_pls_golite062009
  • protein binding
    		•  2.66728689880621 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.19167058827256 bayes_pls_golite062009
  • DNA binding
    		•  2.05514577638135 bayes_pls_golite062009
  • histone binding
    		•  2.00388175060339 bayes_pls_golite062009
  • transcription activator activity
    		•  1.46529895769882 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.10020047862576 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  0.998957812785999 bayes_pls_golite062009
  • general transcriptional repressor activity
    		•  0.75184432495983 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.726970683178132 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  0.494788451379878 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.294457188332415 bayes_pls_golite062009
  • catalytic activity
    		•  0.14067200158938 bayes_pls_golite062009
    2
    Term Confidence Notes
  • transcription repressor activity
    		•  4.08500855631983 bayes_pls_golite062009
  • transcription regulator activity
    		•  3.64390820819794 bayes_pls_golite062009
  • methylated histone residue binding
    		•  3.42338304360938 bayes_pls_golite062009
  • chromatin binding
    		•  3.1924157640698 bayes_pls_golite062009
  • binding
    		•  3.06758476214113 bayes_pls_golite062009
  • protein binding
    		•  2.66728689880621 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.19167058827256 bayes_pls_golite062009
  • DNA binding
    		•  2.05514577638135 bayes_pls_golite062009
  • histone binding
    		•  2.00388175060339 bayes_pls_golite062009
  • transcription activator activity
    		•  1.46529895769882 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.10020047862576 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  0.998957812785999 bayes_pls_golite062009
  • general transcriptional repressor activity
    		•  0.75184432495983 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.726970683178132 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  0.494788451379878 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.294457188332415 bayes_pls_golite062009
  • catalytic activity
    		•  0.14067200158938 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle