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Protein Overview: Upf2-PA

General Information:
Name(s) found: Upf2-PA / FBpp0071072 [FlyBase]
Description(s) found:
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  • gi|85857494|gb|ABC86283.1| RE04053p [Drosophila melanogaster] [NCBI NR]
  • gi|7290872|gb|AAF46314.1| Upf2 [Drosophila melanogaster] [NCBI NR]
  • gi|24640488|ref|NP_572434.1| Upf2 [Drosophila melanogaster] [NCBI NR]
  • The gene Upf2 is referred to in FlyBase by the symbol Dmel\Upf2 (CG2253, FBgn0029992). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:7964277..7969508. It has the cytological map location 7D5. An electronic pipeline based on InterPro domains suggests that it has the molecular function</span>: protein binding. There is experimental evidence that it is involved in the biological process</span>: nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. One allele is reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
  • >CG2253-PA translation from_gene[CG2253 CG2253 FBgn0029992] seq_release:3 mol_weight=140058 cds_boundaries:(X:7,810,234..7,814,101[-]) aa_length:1241 transcript_info:[CG2253-RA seq_release:3] gene_info:[gene symbol:CG2253 FBgn0029992 gene_boundaries:(X [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q9W3L1) CG2253 protein [DrosMelano7227.FASTAC.txt]
  • (AE003442) CG2253 gene product [Drosophila melanogaster] [yeastflysequest.fasta]
  • CG2253-PA [Drosophila melanogaster]gi|24640488|ref|NP_572434.1| CG2253-PA [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=X:complement(7965318..7966097,7966162..7966453,7966535..7969188); ID=FBpp0071072; name=Upf2-PA; parent=FBgn0029992,FBtr0071117; dbxref=FlyBase:FBpp0071072,FlyBase_Annotation_IDs:CG2253-PA,GB_protein:AAF46314.1,REFSEQ:NP_572434,GB_protein [fly-100309-contam.fasta]
  • Upf2 CG2253-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • CG2253-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • RE04053p [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=X:complement(7965318..7966097,7966162..7966453,7966535..7969188); ID=FBpp0071072; name=Upf2-PA; parent=FBgn0029992,FBtr0071117; dbxref=FlyBase:FBpp0071072,FlyBase_Annotation_IDs:CG2253-PA,GB_protein:AAF46314.1,REFSEQ:NP_572434,GB_protein:AAF46314; MD5=6cb406acba64378e799baeeed175963a; length=1241; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=X:complement(7965318..7966097,7966162..7966453,7966535..7969188); ID=FBpp0071072; name=Upf2-PA; parent=FBgn0029992,FBtr0071117; dbxref=FlyBase:FBpp0071072,FlyBase_Annotation_IDs:CG2253-PA,GB_protein:AAF46314.1,REFSEQ:NP_572434,GB_protein:AAF46314; MD5=6cb406acba64378e799baeeed175963a; length=1241; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • RE04053p OS=Drosophila melanogaster GN=Upf2 PE=2 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=X:complement(7965318..7966097,7966162..7966453,7966535..7969188); ID=FBpp0071072; name=Upf2-PA; parent=FBgn0029992,FBtr0071117; dbxref=FlyBase:FBpp0071072,FlyBase_Annotation_IDs:CG2253-PA,GB_protein:AAF46314.1,REFSEQ:NP_572434,GB_protein:AAF46314,FlyMine:FBpp0071072,modMine:FBpp0071072; MD5=6cb406acba64378e799baeeed175963a; length=1241; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=X:complement(join(8072502..8075155,8072129..8072420,8071285..8072064)); ID=FBpp0071072; name=Upf2-PA; parent=FBgn0029992,FBtr0071117; dbxref=FlyBase:FBpp0071072,FlyBase_Annotation_IDs:CG2253-PA,GB_protein:AAF46314.1,REFSEQ:NP_572434,GB_protein:AAF46314,FlyMine:FBpp0071072,modMine:FBpp0071072; MD5=6cb406acba64378e799baeeed175963a; length=1241; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=X:complement(join(8072502..8075155,8072129..8072420,8071285..8072064)); ID=FBpp0071072; name=Upf2-PA; parent=FBgn0029992,FBtr0071117; dbxref=FlyBase:FBpp0071072,FlyBase_Annotation_IDs:CG2253-PA,GB_protein:AAF46314.1,REFSEQ:NP_572434,GB_protein:AAF46314,FlyMine:FBpp0071072,modMine:FBpp0071072; MD5=6cb406acba64378e799baeeed175963a; length=1241; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • RE04053p OS=Drosophila melanogaster GN=Upf2 PE=1 SV=1 [DROME.fasta.20160308]
  • FBpp0071072 type=protein; loc=X:complement(join(8072502..8075155,8072129..8072420,8071285..8072064)); ID=FBpp0071072; name=Upf2-PA; parent=FBgn0029992,FBtr0071117; dbxref=FlyBase:FBpp0071072,FlyBase_Annotation_IDs:CG2253-PA,GB_protein:AAF46314.1,REFSEQ:NP_572434,GB_protein:AAF46314,FlyMine:FBpp0071072,modMine:FBpp0071072; MD5=6cb406acba64378e799baeeed175963a; length=1241; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=X:complement(join(8072502..8075155,8072129..8072420,8071285..8072064)); ID=FBpp0071072; name=Upf2-PA; parent=FBgn0029992,FBtr0071117; dbxref=FlyBase:FBpp0071072,FlyBase_Annotation_IDs:CG2253-PA,GB_protein:AAF46314.1,REFSEQ:NP_572434,GB_protein:AAF46314,UniProt/TrEMBL:Q9W3L1,FlyMine:FBpp0071072,modMine:FBpp0071072; MD5=6cb406acba64378e799baeeed175963a; length=1241; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 1241 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: RNA metabolic process [IEA]
    nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [IMP]
    [NOT]gene silencing by miRNA [IMP]
    [NOT]RNA interference [IMP]
    Molecular Function: protein binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLANDSATTD SEVSTPPSSR KDLADGVAEG DNDNDIDTGD TDANADEDVD AAAAIALEAE  60
   61 EREELQQFIS ELREKIESKR QLRLQNSTIE LPGEEYFAKL DSNLKKNTAF VKKLKLFTAT 120
  121 QLDGLLREIS ALNLSKYISE ICAALVEAKL KMTDVPAVVT LASRLHCTYA DFDVHFLEAW 180
  181 QKALNIKATE KIGNPSKLRV DLRLFAELVS SGVIQMKPGL AQLGVVLVHL IALDKDDHSN 240
  241 FSIILSFCRH CGEEYAGLVP QKMQQLATKY GVEVPKSDFL TADKQLNLRT MLKGYFKALC 300
  301 KHVLAEQAEL MNMTKNIRRT MECKGEISTE KREKCELMQA GFDKLLASAQ SLSELLGEPL 360
  361 PELAKESEGC NPGTVIDNML DSASFGVLDP WGDEETRAFY TDLPDLRQFL PNFSAPKVDL 420
  421 ETLEEPSELT EEAIDANLDA EMDLDDPPST TSDTTPENPI EEQPTTPVAA AEDLKPQKMG 480
  481 NALMELGRQQ QQQSQLNQNP IQIQNQMRQQ FDGFLVNLFN CVNKELIDSA AIEFLLNFNT 540
  541 KHQRKKLTRT IFSVQRTRLD ILPYLSRFVA IVHMCNTDVA TDLAELLRKE FKWHIHKKNQ 600
  601 LNIETKLKIV RFIGELVKFG LFKKFDALGC LKMLLRDFQH HQIEMACAFV EVTGVYLYNC 660
  661 RDARLLMNVF LDQMLRLKTA TAMDSRHAAQ IESVYYLVKP PESSKREPMV RPAMHEYIRY 720
  721 LIFEELCKQN VDRCIKMLRR IDWQDPETNC YAIKCLSKAY LLRFQLIRCL ADLVSGLSSY 780
  781 QPRAVTIVID NVFEDIRAGL EIHSPRMAQR RIAMAKYLGE MYNYKLVEST NILNTLYSII 840
  841 SLGVSNDQNV VSPLDPPDSL FRLKLACMLL DTCAPYFTSQ ATRKKLDYFL VFFQHYYWFK 900
  901 KSHPVFSKTE NTSDLFPILM DHTYRDCLLN VRPKLKIYKS LEQAKAAIDH LQEKLYPQLK 960
  961 TTNNAQDPSL GTISEISEID EGGTDEDSGS SNDQRERQVS GQEQDQSNDW TENEAEPPLP1020
 1021 PLPPPEKSKE DLEFEQLYEK MTTDSYQERL KEPIKATAKD IPVPMMARLQ KKSYDQITGA1080
 1081 QTIGPGINNM SQISKSVPNQ DGTPGSPGAD SPDGNGKSGG GVGGSDVGAA GAAGASGATS1140
 1141 VPFVLMVRGH KGGKQQFKSF VAPSDSHLAT NLKRQEQMIR EEKEKVKRLT LNITERIEEE1200
 1201 DYQESLMPPQ HRNFTQSYYQ KPNKHKFKHQ KGAPDADLIF H

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..370] PSI-BLAST 20.0 Heavy meromyosin subfragment
    2 View Details [371..473] deduced N/A No confident structure predictions are available.
    3 View Details [474..728] PSI-BLAST 24.045757 Eukaryotic initiation factor eIF4G
    4 View Details [729..958] PSI-BLAST 96.221849 The structural basis of the interaction between nonsense mediated decay factors UPF2 and UPF3
    5 View Details [959..1025] deduced N/A No confident structure predictions are available.
    6 View Details [1026..1241] MSA 1.038973 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • RNA binding
    		•  1.23334705954471 bayes_pls_golite062009
  • binding
    		•  1.13433258588739 bayes_pls_golite062009
  • protein binding
    		•  0.321971103983539 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.222038432626885 bayes_pls_golite062009
  • catalytic activity
    		•  0.0114279309788371 bayes_pls_golite062009
    4
    Term Confidence Notes
  • RNA binding
    		•  1.23334705954471 bayes_pls_golite062009
  • binding
    		•  1.13433258588739 bayes_pls_golite062009
  • protein binding
    		•  0.321971103983539 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.222038432626885 bayes_pls_golite062009
  • catalytic activity
    		•  0.0114279309788371 bayes_pls_golite062009
    5 No functions predicted.
    6 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.91

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle