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Protein Overview: l(1)G0255-PB

General Information:
Name(s) found: l(1)G0255-PB / FBpp0070915 [FlyBase]
Description(s) found:
Found 20 descriptions.
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  • The gene lethal (1) G0255 is referred to in FlyBase by the symbol Dmel\l(1)G0255 (CG4094, FBgn0028336). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:6572499..6575887. It has the cytological map location 6C5. Based on sequence similarity, it is predicted to have molecular function</span>: fumarate hydratase activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: tricarboxylic acid cycle. 7 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 467 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [ISS]
    mitochondrion [ISS]
    tricarboxylic acid cycle enzyme complex [IEA]
    Biological Process: tricarboxylic acid cycle [ISS]
    fumarate metabolic process [IEA]
    Molecular Function: fumarate hydratase activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASQEFRVES DTFGELKVPA DKYYGAQTMR SQINFPIGGA TERMPKPVVQ AMGILKKAAA  60
   61 EVNKEFGLDS KVSEAISKAA DDVISGKLYD DHFPLVIWQT GSGTQSNMNV NEVISNRAIE 120
  121 LLGGKLGSKT PVHPNDHVNK SQSSNDTFPT AIHISVALEL NNNLKPAIKT LHDALRAKSE 180
  181 EFKDIIKIGR THTMDAVPLT LGQEFSGYAQ QLAYAQERID ACLPRVYELA LGGTAVGTGL 240
  241 NTRKGFAEKC AAKIAELTSL PFVTAPNKFE ALAARDAMVE VHGVLNTIAV SLMKIANDIR 300
  301 FLGSGPRCGL GELSLPENEP GSSIMPGKVN PTQCESLTML SAQVMGNQVA VTIGGSNGHF 360
  361 ELNVFKPLIV SNVLRSIRLL SDGSRTFTAN CVNGIQANRE NIAKIMNESL MLVTALNPHI 420
  421 GYDKAAKIAK TAHKNGTTLK EEAINLGYLT EQQFNDWVRP EQMLGPK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..467] PSI-BLAST 155.0 RECOMBINANT YEAST FUMARASE

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • fumarate hydratase activity
    		•  4.22589182982073 bayes_pls_golite062009
  • catalytic activity
    		•  2.51282259572665 bayes_pls_golite062009
  • lyase activity
    		•  2.31268471569846 bayes_pls_golite062009
  • carbon-nitrogen lyase activity
    		•  2.2046475419807 bayes_pls_golite062009
  • histidine ammonia-lyase activity
    		•  0.948129236753279 bayes_pls_golite062009
  • amidine-lyase activity
    		•  0.901614580251298 bayes_pls_golite062009
  • binding
    		•  0.854855116369286 bayes_pls_golite062009
  • argininosuccinate lyase activity
    		•  0.617974375213548 bayes_pls_golite062009
  • ammonia-lyase activity
    		•  0.491229595527877 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle