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Protein Overview: l(1)G0148-PA

General Information:
Name(s) found: l(1)G0148-PA / FBpp0070911 [FlyBase]
Description(s) found:
Found 20 descriptions.
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  • The gene lethal (1) G0148 is referred to in FlyBase by the symbol Dmel\l(1)G0148 (CG32742, FBgn0028360). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:6548649..6553742. It has the cytological map location 6C3. It is reported to have molecular function</span>: receptor signaling protein serine/threonine kinase activity. There is experimental evidence that it is involved in the biological process</span>: autophagic cell death; salivary gland cell autophagic cell death. 13 alleles are reported. The phenotype of these alleles is annotated with: third instar larva. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 700 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: autophagic cell death [IEP]
    salivary gland cell autophagic cell death [IEP]
    protein amino acid phosphorylation [IEA][NAS]
    Molecular Function: ATP binding [IEA]
    receptor signaling protein serine/threonine kinase activity [NAS]
    protein serine/threonine kinase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MADRVMCQEL ATPGSHYRRP KTGVPSTNVV YANGGGSWRA APRQTQRLPR QTVQQYATGT  60
   61 PATGSAGRHS GRAFATAGAT EEQTVEFNGA AVMGLPATPR TTKQARNKSE EAINDLLTRI 120
  121 PDIGKLFDVH SRIGNGTFST VLLGTLRRES HLPDSLRRKF AIKHHIPTSH PDRIMKELQC 180
  181 MTKMGGKENV VGIHCCMRYD ASAAFVMPFM AHDRFQDFYT RMDVPEIRQY MRNLLVALRH 240
  241 VHKFDVIHRD VKPSNFLYNR RRREFLLVDF GLAQHVNPPA ARSSGSAAAI AAANNKNNNN 300
  301 NNNNNSKRPR ERESKGDVQQ IALDAGLGGA VKRMRLHEES NKMPLKPVND IAPSDAPEQS 360
  361 VDGSNHVQPQ LVQQEQQQLQ PQQQQQQQQQ QQQSQQQQQP QQQSQQQHPQ RQPQLAQMDQ 420
  421 TASTPSGSKY NTNRNVSAAA ANNAKCVCFA NPSVCLNCLM KKEVHASRAG TPGYRPPEVL 480
  481 LKYPDQTTAV DVWAAGVIFL SIMSTVYPFF KAPNDFIALA EIVTIFGDQA IRKTALALDR 540
  541 MITLSQRSRP LNLRKLCLRF RYRSVFSDAK LLKSYESVDG SCEVCRNCDQ YFFNCLCEDS 600
  601 DYLTEPLDAY ECFPPSAYDL LDRLLEINPH KRITAEEALK HPFFTAAEEA EQTEQDQLAN 660
  661 GTPRKMRRQR YQSHRTVAAS QEQVKQQVAL DLQQAAINKL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..68] deduced N/A No confident structure predictions are available.
    2 View Details [69..405] PSI-BLAST 64.69897 No description for 2gnfA was found.
    3 View Details [406..700] FFAS03 7.25 Crystal Structure of Human CDK7

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • protein kinase activity
    		•  4.41111855953173 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  4.25240940733767 bayes_pls_golite062009
  • kinase activity
    		•  4.13594666977573 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  3.89079310460523 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  3.4213741424174 bayes_pls_golite062009
  • transferase activity
    		•  3.21580775609322 bayes_pls_golite062009
  • catalytic activity
    		•  1.50703903453177 bayes_pls_golite062009
  • ATP binding
    		•  1.29379418417493 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.26894460718531 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.23549663199841 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.05135330738318 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.05092123230729 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.02030539684589 bayes_pls_golite062009
  • nucleotide binding
    		•  1.01160654844821 bayes_pls_golite062009
  • binding
    		•  0.742039050214458 bayes_pls_golite062009
  • protein binding
    		•  0.455661276339377 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  0.405598428430838 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  0.342566496914563 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  0.301668095839736 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.86

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle