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Protein Overview: Top3beta-PA, FBp...

General Information:
Name(s) found: FBpp0309042 [FlyBase]
Top3beta-PA / FBpp0070891 [FlyBase]
Description(s) found:
Found 29 descriptions.
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  • type=protein; loc=X:complement(6178580..6178923,6179007..6179400,6179465..6180515,6180855..6181602,6181674..6181764); ID=FBpp0309042; name=Top3beta-PB; parent=FBgn0026015,FBtr0340028; dbxref=FlyBase:FBpp0309042,FlyBase_Annotation_IDs:CG3458-PB; MD5=61f5bfa6a44ada8c22e49a7090f72bae; length=875; release=r5.56; species=Dmel; [FlyBase]
  • The gene Topoisomerase 3Ã?&#142;Ã?² is referred to in FlyBase by the symbol Dmel\Top3Ã?&#142;Ã?² (CG3458, FBgn0026015). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:6178171..6181997. It has the cytological map location 5E5. There is experimental evidence that it has the molecular function</span>: DNA topoisomerase activity; endodeoxyribonuclease activity. There is experimental evidence that it is involved in the biological process</span>: DNA catabolic process, endonucleolytic. 13 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 875 amino acids

    Gene Ontology:
    Cellular Component: chromosome [IEA]
    Biological Process: DNA catabolic process, endonucleolytic [IDA]
    DNA topological change [IEA]
    DNA metabolic process [IEA]
    DNA unwinding involved in replication [IEA]
    Molecular Function: DNA topoisomerase activity [IDA][NAS]
    DNA topoisomerase type I activity [ISS][NAS]
    endodeoxyribonuclease activity [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKSVLMVAEK PSLAASLAGI LSNGRCTAKR GTGNGCSTHE WTGNFRNEGS VHFRMTSVCG  60
   61 HVMSLDFNKK YNCWDKVDPI QLFGCATEKK ETNPKQNMRK FLAHEARGCD YLVLWLDCDK 120
  121 EGENICFEVM DAVKHVINNV YSDQVTYRAH FSAITEKDIK KAMETLGHPN ENEAKSVDAR 180
  181 QELDLRIGCA FTRFQTKFFQ DRYGDLDSSL ISYGPCQTPT LGFCVKRHDD IQTFKPESFW 240
  241 HLQLLAGQPE VTLEWARGRV FKKDIAIMLL NRVKEHKKAT VESVASKEAY KSKPQALNTV 300
  301 ELMRICSSGL GIGPFQAMQI AERLYTQGYI SYPRTETNQY PTNFDLPAVL HVLKPSADFG 360
  361 EEARSILGDI QTPRKGKDAG DHPPITPMKL GNRSDFDRDT WRVYEFICRH FMGTVSRDLK 420
  421 YRVTTAKLSV GMETFSCTAS VLIDAGFTKV MTWSAFGKDE PQPPFVQGTQ VAINDVRLIE 480
  481 SQTGPPDYLT ESELITLMEE HGIGTDASIP VHINNICQRN YVHIENGRKL MPTTLGIVLV 540
  541 HGYQKIDPEL VLPTMRTEVE RMLTLIAQGS ANFQDVLRHA IKIFKLKFMY FVKNIDSMDA 600
  601 LFEVSFSPLA ESGKAHSRCG KCRRYMKYIQ TKPARLHCSH CDETYALPIG NVKVYREFKC 660
  661 PLDDFDLLAF STGVKGRSYP FCPYCYNHPP FSDMPHLGGC NTCTNANCPH SLNTLGISSC 720
  721 VECPTGVLVL DCTLAPTWKL GCNRCDVIIN CFKGATKITV EEAKCQECGA QQVNVVYKSD 780
  781 KSKFKDGSEE KSGCIFCSAD FSHLVEKHRA VASRPVRSGG GFRGGKAGRG GGGMGGAAFG 840
  841 SGGAVTAGGG PNAGGGVRGS RVAKDKMGQL ASYFV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..599] PSI-BLAST 172.0 AMINO TERMINAL 67KDA DOMAIN OF ESCHERICHIA COLI DNA TOPOISOMERASE I (RESIDUES 2-590 OF MATURE PROTEIN) CLONING ARTIFACT ADDS TWO RESIDUES TO THE AMINO-TERMINUS WHICH WERE NOT OBSERVED IN THE EXPERIMENTAL ELECTRON DENSITY (GLY-2, SER-1).
    2 View Details [600..698] FFAS03 1.02 No description for 2fe3A was found.
    3 View Details [699..875] PSI-BLAST 34.09691 No description for 2i13A was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • DNA topoisomerase activity
    		•  10.2798831210729 bayes_pls_golite062009
  • DNA topoisomerase type I activity
    		•  8.04585827786358 bayes_pls_golite062009
  • isomerase activity
    		•  5.61256457337998 bayes_pls_golite062009
  • DNA binding
    		•  5.20730175008144 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.95671919332271 bayes_pls_golite062009
  • binding
    		•  4.3089127577748 bayes_pls_golite062009
  • catalytic activity
    		•  1.50449367975676 bayes_pls_golite062009
  • hydrolase activity
    		•  0.715654828097203 bayes_pls_golite062009
  • protein binding
    		•  0.377429709958808 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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