Protein Overview: eIF2B-epsilon-PB...

General Information:
Name(s) found:	eIF2B-epsilon-PB / FBpp0089217 [FlyBase] eIF2B-epsilon-PA / FBpp0070336 [FlyBase]
Description(s) found: Found 36 descriptions. SHOW ALL	The gene eIF2B-Ă?Ă?Âľ is referred to in FlyBase by the symbol Dmel\eIF2B-Ă?Ă?Âľ (CG3806, FBgn0023512). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:1814199..1816917. It has the cytological map location 2B16. There is experimental evidence that it has the molecular function</span>: guanyl-nucleotide exchange factor activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: translational initiation. One allele is reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase] The gene eIF2B-Ă?Ă?Âľ is referred to in FlyBase by the symbol Dmel\eIF2B-Ă?Ă?Âľ (CG3806, FBgn0023512). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:1814199..1816917. It has the cytological map location 2B16. There is experimental evidence that it has the molecular function</span>: guanyl-nucleotide exchange factor activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: translational initiation. One allele is reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
Organism:	Drosophila melanogaster
Length:	669 amino acids
Gene Ontology:
Cellular Component:	cytosol [ISS] eukaryotic translation initiation factor 2B complex [ISS][TAS]
Biological Process:	translational initiation [ISS]
Molecular Function:	translation initiation factor activity [ISS] nucleotidyltransferase activity [IEA] guanyl-nucleotide exchange factor activity [IDA][ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAQFEKEIVQ AVLIADNNVW NFKPLSDEGS TALLPLVNVR MLDYALMALN RSGVEEVFVY  60
   61 TSLYRSSIRE HIRAGIATDA AWSFKMTVHV IGGEGCRCFG DAMRDLDNKA LIRGHFILLG 120
  121 ADTVTNADLR PVLEQHKRQA KFDKGTAATL VFKECANNVR TGNEVLIAVD RRNDRLHYHQ 180
  181 RLRMHHKENR YQLPLDVFLG NSCVALHHNL LDPQIAIGSP SMLSLFNDNF DFQTRDDFVR 240
  241 GLLINEELLD SRIYVALLPA AQYAHKVNNW PAYQLVSRDI INRWAYPFVP DIGLYKLQQE 300
  301 YVFHKDNIYK SPEAHVSKVA LLQNVVIEAG SHVDSGSVIS DSVIGANCRI GKNCRLTNAF 360
  361 LMADVTVMDN CRLEHCVVGE GAIINEDCDV SAGCVLGAKS VLPAKKTLAK TLITRTPSRR 420
  421 RSDDEVVVEL KSIGPHAYIV SDLTTGDPED SECEDLLPQQ PLSIPKMGDL LAPLDEISYC 480
  481 SDFSEDDEDA SRAVTPLPDD TNIFLGEVID SLTRGFREKS NPDFLVLEIN SSRYAYNMSL 540
  541 KEVNFNVVKA VFGMQSIVEP ANDNVLVAIN AAFKQLGPVV SNYIKSEDSM MDCLKALEDV 600
  601 YEENHLVRGK ISQIVHYLYD KDFVSESAIQ AWYAQLDEEE HAHLRQSLAK LVAWLDQSSE 660
  661 EDDDEEDDD

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Searching the YRC Public Image Repository, found results:

Currently showing to of results.

[View Search in the YRC Public Image Repository]

Searching the YRC Public Image Repository, found no results.

Ginzu Version Information

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Gene Ontology predictions

Term	Confidence	Notes
transferase activity	2.17535315350752	bayes_pls_golite062009
catalytic activity	1.88676710996045	bayes_pls_golite062009
nucleotidyltransferase activity	1.86990263440735	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.49149681135671	bayes_pls_golite062009
binding	1.09657219604879	bayes_pls_golite062009
protein binding	0.967722609820275	bayes_pls_golite062009
transferase activity, transferring hexosyl groups	0.796949457473955	bayes_pls_golite062009
acyltransferase activity	0.741838450922005	bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups	0.717805296858439	bayes_pls_golite062009
UDP-glycosyltransferase activity	0.619458068514795	bayes_pls_golite062009
transferase activity, transferring acyl groups	0.555398952276587	bayes_pls_golite062009
O-acyltransferase activity	0.319932817519902	bayes_pls_golite062009

Term	Confidence	Notes
translation initiation factor activity	9.37171190530754	bayes_pls_golite062009
translation regulator activity	5.35226950142169	bayes_pls_golite062009
binding	3.0667965351474	bayes_pls_golite062009
structural molecule activity	2.87774614675757	bayes_pls_golite062009
protein binding	2.78733902345842	bayes_pls_golite062009
nucleic acid binding	2.34284977509828	bayes_pls_golite062009
RNA binding	1.98024495780436	bayes_pls_golite062009
transcription regulator activity	1.76231475025891	bayes_pls_golite062009
RNA cap binding	1.73309326409609	bayes_pls_golite062009
mRNA binding	1.71342954033223	bayes_pls_golite062009
DNA binding	1.62032607987786	bayes_pls_golite062009
transcription activator activity	1.23830945970239	bayes_pls_golite062009
transcription factor activity	0.923253759652909	bayes_pls_golite062009
translation factor activity, nucleic acid binding	0.803700928110921	bayes_pls_golite062009
protein phosphatase binding	0.18767619609331	bayes_pls_golite062009

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.98

Source: Reynolds et al. (2008)

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..470]	PSI-BLAST	59.0	N-acetylglucosamine 1-phosphate uridyltransferase GlmU, C-terminal domain; N-acetylglucosamine 1-phosphate uridyltransferase GlmU, N-terminal domain
2	View Details	[471..669]	PSI-BLAST	30.522879	CRYSTAL STRUCTURE OF THE CATALYTIC FRAGMENT OF EUKARYOTIC INITIATION FACTOR 2B EPSILON

Protein Overview: eIF2B-epsilon-PB...

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: