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Protein Overview: CDC45L-PA

General Information:
Name(s) found: CDC45L-PA / FBpp0070175 [FlyBase]
Description(s) found:
Found 26 descriptions.
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  • The gene CDC45L is referred to in FlyBase by the symbol Dmel\CDC45L (CG3658, FBgn0026143). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:922320..924606. It has the cytological map location 1E1. There is experimental evidence that it has the molecular function</span>: 3'-5' DNA helicase activity; chromatin binding. There is experimental evidence that it is involved in the biological process</span>: DNA amplification; DNA replication; positive regulation of S phase of mitotic cell cycle; chromosome condensation. 4 alleles are reported. The phenotype of these alleles is annotated with: nuclear chromosome. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 575 amino acids

    Gene Ontology:
    Cellular Component: pre-replicative complex [IPI][ISS]
    nucleus [IDA]
    cytoplasm [IDA]
    Biological Process: DNA replication initiation [ISS]
    positive regulation of S phase of mitotic cell cycle [IMP]
    DNA replication [IPI][ISS]
    chromosome condensation [IMP]
    DNA amplification [IEP]
    Molecular Function: DNA binding [ISS]
    chromatin binding [IDA]
    3'-5' DNA helicase activity [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFVQDLRNDF YRQLVGKRIL IVVNYDIDAI CASRILQALF KYDHMLYTVV PIMGVTGLKR  60
   61 AYGEHQGDVK YVVLVNCGGC VDIVELLQPS DDVTFFICDS HRPLDVCNIY SDRQVCILGD 120
  121 ASLEENIPAF ETIFYDSEGE DEDEDESSDT EQQHDDSGAG ESDQEDQAPR SRKLSRLERH 180
  181 EQRILKQRAR RQWESERDRI MFEYTQFSYY GRSAALMVFE LAWKLSKDNM DLLWWAIVGI 240
  241 TEQLLLGKIE SGAYTLELEQ IQSHVSRLTN KTNDQNTMSA SKITFENDLH LVLYRHWPVT 300
  301 ESMRYSRYSS CQLKLWTLRG EKRLHELLLE MGLPLVHARQ TYGAMDLVLR KEFFSMVERL 360
  361 AEKYDIADIV YGTFTLSYGY RSRYAAADYV YALLAIMESV KKHKTPEDCF LEASDALSRQ 420
  421 HKQLLSAGID QAKLLHAAVF RQVQSSLEAR QVHSAGSFFY YVLQEEHAFF SYPYALGLLA 480
  481 RFLLRGHVAT SRARQASDLP LIASCPLNAS EGMCLLVGIV PVREDSPRNF FGKAFEQAAQ 540
  541 KSGVALLQDF FEPAVVQLRQ SDLTRFLDSL TVLLA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..269] MSA 1.031974 View MSA. No confident structure predictions are available.
    2 View Details [270..403] MSA 1.032977 View MSA. No confident structure predictions are available.
    3 View Details [404..575] MSA 1.031952 View MSA. No confident structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.79

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle