Protein Overview: tw-PA, FBpp0307386

General Information:
Name(s) found:	FBpp0307386 [FlyBase] tw-PA / FBpp0070134 [FlyBase]
Description(s) found: Found 31 descriptions. SHOW ALL	type=protein; loc=X:join(678938..679047,679123..679206,679267..679351,679421..679525,679580..679688,679750..680531,680602..680842,680907..681055,681119..681557,681672..681865); ID=FBpp0307386; name=tw-PB; parent=FBgn0086368,FBtr0335403; dbxref=REFSEQ:NP_001259102,GB_protein:AGB94948,FlyBase:FBpp0307386,FlyBase_Annotation_IDs:CG12311-PB; MD5=ad9a0d8f9cf376490ec4d4a9e039edee; length=765; release=r5.56; species=Dmel; [FlyBase] The gene Protein O-mannosyltransferase 2 is referred to in FlyBase by the symbol Dmel\tw (CG12311, FBgn0086368). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:678824..682077. It has the cytological map location 1C4-1D4. There is experimental evidence that it has the molecular function</span>: dolichyl-phosphate-mannose-protein mannosyltransferase activity. There is experimental evidence that it is involved in the biological process</span>: protein amino acid O-linked mannosylation; sarcomere organization; muscle attachment. 18 alleles are reported. The phenotypes of these alleles are annotated with: abdomen; adult abdomen; male genitalia. It has one annotated transcript and one annotated polypeptide. [FlyBase]
Organism:	Drosophila melanogaster
Length:	765 amino acids
Gene Ontology:
Cellular Component:	membrane [IEA] integral to membrane [ISS] endoplasmic reticulum [IDA]
Biological Process:	sarcomere organization [IGI] protein amino acid O-linked mannosylation [IDA] muscle attachment [IGI]
Molecular Function:	dolichyl-phosphate-mannose-protein mannosyltransferase activity [IDA][ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAASVVKTPK CPRRGSVKDV AQNAPRTAPT SSKEANWNWW LLLATVFLVT FATRFYKVTE  60
   61 PDHICWDETH FGKMGSWYIN RTFFFDVHPP LGKMLIGLSG YLTGYNGTFP FEKPGDKYNE 120
  121 TRYQGMRYFC TTLGALIMPM GFDTVYDLTR SHEAALLAAA YLIFDVGLLT LNQYILLDPI 180
  181 LLFFMMASVW GMVKVSKSTA SGGSYGLRWW LWLFLTGTML SCTISVKFVG LFVVLLVGLH 240
  241 TATELWLILG DLGQPILETV KQLACRAITL IVWPVLLYIL FFYIHLSVLN RSGNGDGFYS 300
  301 SAFQSRLIGN SLYNASMPRD VAYGSLVTIK NHKTGGGYLH SHHHLYPKGS GARQQQVTTY 360
  361 THKDENNKWL IRPHNKPGPP KGKVQILRHG DLVRLTHMAT RRNLHSHNEP APMTKKHLQV 420
  421 TGYGELGLGD ANDVWRVLIV GGKVNETVHT VTSRLKFIHL LQNCALTSSG KQLPKWGFEQ 480
  481 QEVSCNPNVR DKNSQWNVED NEHKLMPSVS FSVYAPGFFA RFLESHAVML QGNAGLKPKE 540
  541 GEVTSRPWQW PINYRGQFFS GSSYRIYLLG NPLIWWSNLV FLALFVTVFL CNAVVQQRRA 600
  601 GFARSAAQNQ AQVPDSETVA QDEESEHSTT DICSCCTPAK EIVPKAVPSG SPEAPNPAQS 660
  661 LRAAAWLFLG WMLHYLPFWA MGRVLYFHHY FPALIFNSLL TGVMYNYILR VLPKWIHHVI 720
  721 LGLVLSILVY SFAAFSPLAY GMSGPLANEP NSTMYNLKWL STWEF

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Searching the YRC Public Image Repository, found results:

Currently showing to of results.

[View Search in the YRC Public Image Repository]

Searching the YRC Public Image Repository, found no results.

Ginzu Version Information

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Gene Ontology predictions

No functions predicted.

Term	Confidence	Notes
dolichyl-phosphate-mannose-protein mannosyltransferase activity	7.33543412640964	bayes_pls_golite062009
mannosyltransferase activity	6.32966341675541	bayes_pls_golite062009
transferase activity, transferring hexosyl groups	2.60661923349025	bayes_pls_golite062009
receptor activity	1.98562812678228	bayes_pls_golite062009
cation channel activity	1.66500687404195	bayes_pls_golite062009
ion channel activity	1.61859406934521	bayes_pls_golite062009
substrate-specific channel activity	1.57127083095499	bayes_pls_golite062009
passive transmembrane transporter activity	1.55374970486978	bayes_pls_golite062009
channel activity	1.55374970486978	bayes_pls_golite062009
inositol-1,4,5-trisphosphate receptor activity	1.54960024640698	bayes_pls_golite062009
binding	1.28645358261768	bayes_pls_golite062009
molecular transducer activity	1.01765765844557	bayes_pls_golite062009
signal transducer activity	1.01765765844557	bayes_pls_golite062009
transferase activity	0.981084601370981	bayes_pls_golite062009
calcium channel activity	0.85901349040585	bayes_pls_golite062009
transferase activity, transferring glycosyl groups	0.802620463808905	bayes_pls_golite062009
catalytic activity	0.659936859803906	bayes_pls_golite062009
calcium-release channel activity	0.65133561512386	bayes_pls_golite062009
gated channel activity	0.53737429019655	bayes_pls_golite062009
ligand-gated ion channel activity	0.52162184692236	bayes_pls_golite062009
ligand-gated channel activity	0.52162184692236	bayes_pls_golite062009
protein binding	0.428075756729427	bayes_pls_golite062009

No functions predicted.

Source: Reynolds et al. 2008. Manuscript submitted

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..315]	MSA	10.978995	View MSA. No confident structure predictions are available.
2	View Details	[316..512]	PSI-BLAST	47.0	Structural genomics of Caenorhabditis elegans: Structure of a protein with unknown function
3	View Details	[513..672]	deduced	N/A	No confident structure predictions are available.
4	View Details	[673..765]	MSA	2.082986	View MSA. No confident structure predictions are available.

Protein Overview: tw-PA, FBpp0307386

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: