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Protein Overview: Actbeta-PA

General Information:
Name(s) found: Actbeta-PA / FBpp0088273 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • The gene Activin-Ã?&#142;Ã?² is referred to in FlyBase by the symbol Dmel\ActÃ?&#142;Ã?² (CG11062, FBgn0024913). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 4:1097946..1105418. It has the cytological map location 102F8. Based on sequence similarity, it is predicted to have molecular function</span>: transforming growth factor beta receptor binding. It is reported to be involved in the biological process</span>: dendrite morphogenesis; cell growth. 8 alleles are reported. The phenotypes of these alleles are annotated with: central nervous system; optic lobe; wing. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 946 amino acids

    Gene Ontology:
    Cellular Component: extracellular region [IEA][NAS]
    Biological Process: cell growth [NAS]
    dendrite morphogenesis [NAS]
    Molecular Function: growth factor activity [IEA]
    transforming growth factor beta receptor binding [ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRFAFDSNHS QSGAPFKGSR CFFNCQCICC RQGCCVVVVK CCCCFNLNCC NSLGSRKSFP  60
   61 QPAAMRKKVA DLEVLRVSRF VAVILVLARW VTAVATLLTS CILLDIFSVP GQSGVADRSQ 120
  121 ASSRTVHVSV PTTPNETPSS TSETKLKLLY GYTSYDINND QQVKSNNLCR VLCKSRNRKR 180
  181 QRRRRRRRNH RRRRHRYTKR LHHLMQDNMS GFEQRLNFSD AKCQSLETNY GTNYDLVQGG 240
  241 KLFSQSERSL LVSPLREIEA PWPAIHGSMR NCSKIKRNRA NLIWLLIGLV WFEVKLINCN 300
  301 GISSSNYYAS NLESHKGCTL CHESGKPNIY TDKDNPHTDY NIYNKYHSNN NFNKKTNQPH 360
  361 NNIAPSDEVR LESIKRQILT KLGLSHKPNV SHPLPKQFIW ETIYRVDGGR MIPNNAFGSS 420
  421 GKNLDQKTIK LRAFASPGSH LFNGRGGRTD QRSERDPSHH KYRSPFDFTF NISKNNVYGK 480
  481 VLRNRSLERI DKKNSFLNGW TENRQLKINS QIASMPIELK SHHNSSPKEL KSGAVRKVNG 540
  541 INGTQMNENA LKKSTYPIDI NHSIDNKTHT GKNGEMSHND YEYFNDYSVQ THDKNRYHEG 600
  601 RSSIGYQPAI HNIEYENQKG HHESFADDHE NIDHEDFFGN TQEIITFAEE GTQYRQYRIL 660
  661 EFSAQNRRVP SQKLSIRSAQ IHIRIDKPHS LWIEKAKSLP EKHLLNTKRK WGANKPHHRI 720
  721 KIWVFQLSTS INITEKGIDK AIIFRASFQV DPKNLGWQKF DLTDTIREWY GHTSHEKLRL 780
  781 LIDCTGCGGR YSLHLFQTSK LRGNSSDYLS TNPNRPFLVL HTESSRTRRV RRRAVDCGGA 840
  841 LNGQCCKESF YVSFKALGWD DWIIAPRGYF ANYCRGDCTG SFRTPDTFQT FHAHFIEEYR 900
  901 KMGLMNGMRP CCAPIKFSSM SLIYYGDDGI IKRDLPKMVV DECGCP

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..219] deduced N/A No confident structure predictions are available.
    2 View Details [220..351] deduced N/A No confident structure predictions are available.
    3 View Details [352..442] MSA 3.007982 View MSA. No confident structure predictions are available.
    4 View Details [443..564] deduced N/A No confident structure predictions are available.
    5 View Details [565..651] MSA 6.286995 View MSA. No confident structure predictions are available.
    6 View Details [652..816] MSA 8.372994 View MSA. No confident structure predictions are available.
    7 View Details [817..946] PSI-BLAST 35.522879 BONE MORPHOGENETIC PROTEIN-7

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7
    Term Confidence Notes
  • receptor binding
    		•  3.67407540757291 bayes_pls_golite062009
  • growth factor activity
    		•  3.00792386593701 bayes_pls_golite062009
  • binding
    		•  2.18106161869951 bayes_pls_golite062009
  • receptor serine/threonine kinase binding
    		•  2.01478614969692 bayes_pls_golite062009
  • protein binding
    		•  2.01254413740256 bayes_pls_golite062009
  • transforming growth factor beta receptor binding
    		•  1.87074199164241 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase binding
    		•  1.87074199164241 bayes_pls_golite062009
  • cell surface binding
    		•  1.71347296916502 bayes_pls_golite062009
  • type II transforming growth factor beta receptor binding
    		•  1.60271967659465 bayes_pls_golite062009
  • vascular endothelial growth factor receptor binding
    		•  1.43930353468665 bayes_pls_golite062009
  • cytokine activity
    		•  1.29821582644036 bayes_pls_golite062009
  • platelet-derived growth factor receptor binding
    		•  1.02262292046677 bayes_pls_golite062009
  • neurotrophin receptor binding
    		•  0.81172494974121 bayes_pls_golite062009
  • heparin binding
    		•  0.8114984612971 bayes_pls_golite062009
  • vascular endothelial growth factor receptor 2 binding
    		•  0.808551053262969 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  0.79853499343535 bayes_pls_golite062009
  • polysaccharide binding
    		•  0.539968806788969 bayes_pls_golite062009
  • growth factor binding
    		•  0.49508779568124 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.426935963412231 bayes_pls_golite062009
  • pattern binding
    		•  0.377711019199199 bayes_pls_golite062009
  • hormone activity
    		•  0.344797552374249 bayes_pls_golite062009
  • vascular endothelial growth factor receptor 1 binding
    		•  0.250978411198471 bayes_pls_golite062009
  • platelet-derived growth factor binding
    		•  0.186615795527151 bayes_pls_golite062009
  • protein homodimerization activity
    		•  0.176088530902184 bayes_pls_golite062009
  • identical protein binding
    		•  0.0880365341657661 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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