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View Structure Prediction Details

Protein: Actbeta-PA
Organism: Drosophila melanogaster
Length: 946 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Actbeta-PA.

Description E-value Query
Range
Subject
Range
gi|126002448, gi... - gi|54640007|gb|EAL29247.1| GA10734-PA [Drosophila pseudoobscura], gi|126002448|ref|XP_001352350.1| G...
839.0 [0..18] [946..1]

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Predicted Domain #1
Region A:
Residues: [1-219]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRFAFDSNHS QSGAPFKGSR CFFNCQCICC RQGCCVVVVK CCCCFNLNCC NSLGSRKSFP  60
   61 QPAAMRKKVA DLEVLRVSRF VAVILVLARW VTAVATLLTS CILLDIFSVP GQSGVADRSQ 120
  121 ASSRTVHVSV PTTPNETPSS TSETKLKLLY GYTSYDINND QQVKSNNLCR VLCKSRNRKR 180
  181 QRRRRRRRNH RRRRHRYTKR LHHLMQDNMS GFEQRLNFS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [220-351]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DAKCQSLETN YGTNYDLVQG GKLFSQSERS LLVSPLREIE APWPAIHGSM RNCSKIKRNR  60
   61 ANLIWLLIGL VWFEVKLINC NGISSSNYYA SNLESHKGCT LCHESGKPNI YTDKDNPHTD 120
  121 YNIYNKYHSN NN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [352-442]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FNKKTNQPHN NIAPSDEVRL ESIKRQILTK LGLSHKPNVS HPLPKQFIWE TIYRVDGGRM  60
   61 IPNNAFGSSG KNLDQKTIKL RAFASPGSHL F

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [443-564]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NGRGGRTDQR SERDPSHHKY RSPFDFTFNI SKNNVYGKVL RNRSLERIDK KNSFLNGWTE  60
   61 NRQLKINSQI ASMPIELKSH HNSSPKELKS GAVRKVNGIN GTQMNENALK KSTYPIDINH 120
  121 SI

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [565-651]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DNKTHTGKNG EMSHNDYEYF NDYSVQTHDK NRYHEGRSSI GYQPAIHNIE YENQKGHHES  60
   61 FADDHENIDH EDFFGNTQEI ITFAEEG

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [652-816]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TQYRQYRILE FSAQNRRVPS QKLSIRSAQI HIRIDKPHSL WIEKAKSLPE KHLLNTKRKW  60
   61 GANKPHHRIK IWVFQLSTSI NITEKGIDKA IIFRASFQVD PKNLGWQKFD LTDTIREWYG 120
  121 HTSHEKLRLL IDCTGCGGRY SLHLFQTSKL RGNSSDYLST NPNRP

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #7
Region A:
Residues: [817-946]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FLVLHTESSR TRRVRRRAVD CGGALNGQCC KESFYVSFKA LGWDDWIIAP RGYFANYCRG  60
   61 DCTGSFRTPD TFQTFHAHFI EEYRKMGLMN GMRPCCAPIK FSSMSLIYYG DDGIIKRDLP 120
  121 KMVVDECGCP 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 35.522879
Match: 1bmpA
Description: BONE MORPHOGENETIC PROTEIN-7
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
receptor binding 3.67407540757291 bayes_pls_golite062009
growth factor activity 3.00792386593701 bayes_pls_golite062009
binding 2.18106161869951 bayes_pls_golite062009
receptor serine/threonine kinase binding 2.01478614969692 bayes_pls_golite062009
protein binding 2.01254413740256 bayes_pls_golite062009
transforming growth factor beta receptor binding 1.87074199164241 bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase binding 1.87074199164241 bayes_pls_golite062009
cell surface binding 1.71347296916502 bayes_pls_golite062009
type II transforming growth factor beta receptor binding 1.60271967659465 bayes_pls_golite062009
vascular endothelial growth factor receptor binding 1.43930353468665 bayes_pls_golite062009
cytokine activity 1.29821582644036 bayes_pls_golite062009
platelet-derived growth factor receptor binding 1.02262292046677 bayes_pls_golite062009
neurotrophin receptor binding 0.81172494974121 bayes_pls_golite062009
heparin binding 0.8114984612971 bayes_pls_golite062009
vascular endothelial growth factor receptor 2 binding 0.808551053262969 bayes_pls_golite062009
glycosaminoglycan binding 0.79853499343535 bayes_pls_golite062009
polysaccharide binding 0.539968806788969 bayes_pls_golite062009
growth factor binding 0.49508779568124 bayes_pls_golite062009
protein dimerization activity 0.426935963412231 bayes_pls_golite062009
pattern binding 0.377711019199199 bayes_pls_golite062009
hormone activity 0.344797552374249 bayes_pls_golite062009
vascular endothelial growth factor receptor 1 binding 0.250978411198471 bayes_pls_golite062009
platelet-derived growth factor binding 0.186615795527151 bayes_pls_golite062009
protein homodimerization activity 0.176088530902184 bayes_pls_golite062009
identical protein binding 0.0880365341657661 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle