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View Structure Prediction Details

Protein: Actbeta-PA
Organism: Drosophila melanogaster
Length: 946 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Actbeta-PA.

Description E-value Query
Range
Subject
Range
gi|126002448, gi... - gi|54640007|gb|EAL29247.1| GA10734-PA [Drosophila pseudoobscura], gi|126002448|ref|XP_001352350.1| G...
839.0 [0..18] [946..1]

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Predicted Domain #1
Region A:
Residues: [1-219]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRFAFDSNHS QSGAPFKGSR CFFNCQCICC RQGCCVVVVK CCCCFNLNCC NSLGSRKSFP  60
   61 QPAAMRKKVA DLEVLRVSRF VAVILVLARW VTAVATLLTS CILLDIFSVP GQSGVADRSQ 120
  121 ASSRTVHVSV PTTPNETPSS TSETKLKLLY GYTSYDINND QQVKSNNLCR VLCKSRNRKR 180
  181 QRRRRRRRNH RRRRHRYTKR LHHLMQDNMS GFEQRLNFS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [220-351]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DAKCQSLETN YGTNYDLVQG GKLFSQSERS LLVSPLREIE APWPAIHGSM RNCSKIKRNR  60
   61 ANLIWLLIGL VWFEVKLINC NGISSSNYYA SNLESHKGCT LCHESGKPNI YTDKDNPHTD 120
  121 YNIYNKYHSN NN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [352-442]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FNKKTNQPHN NIAPSDEVRL ESIKRQILTK LGLSHKPNVS HPLPKQFIWE TIYRVDGGRM  60
   61 IPNNAFGSSG KNLDQKTIKL RAFASPGSHL F

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [443-564]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NGRGGRTDQR SERDPSHHKY RSPFDFTFNI SKNNVYGKVL RNRSLERIDK KNSFLNGWTE  60
   61 NRQLKINSQI ASMPIELKSH HNSSPKELKS GAVRKVNGIN GTQMNENALK KSTYPIDINH 120
  121 SI

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [565-651]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DNKTHTGKNG EMSHNDYEYF NDYSVQTHDK NRYHEGRSSI GYQPAIHNIE YENQKGHHES  60
   61 FADDHENIDH EDFFGNTQEI ITFAEEG

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [652-816]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TQYRQYRILE FSAQNRRVPS QKLSIRSAQI HIRIDKPHSL WIEKAKSLPE KHLLNTKRKW  60
   61 GANKPHHRIK IWVFQLSTSI NITEKGIDKA IIFRASFQVD PKNLGWQKFD LTDTIREWYG 120
  121 HTSHEKLRLL IDCTGCGGRY SLHLFQTSKL RGNSSDYLST NPNRP

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #7
Region A:
Residues: [817-946]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FLVLHTESSR TRRVRRRAVD CGGALNGQCC KESFYVSFKA LGWDDWIIAP RGYFANYCRG  60
   61 DCTGSFRTPD TFQTFHAHFI EEYRKMGLMN GMRPCCAPIK FSSMSLIYYG DDGIIKRDLP 120
  121 KMVVDECGCP 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 35.522879
Match: 1bmpA
Description: BONE MORPHOGENETIC PROTEIN-7
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
receptor binding 3.67407540757291 bayes_pls_golite062009
growth factor activity 3.00792386593701 bayes_pls_golite062009
binding 2.18106161869951 bayes_pls_golite062009
receptor serine/threonine kinase binding 2.01478614969692 bayes_pls_golite062009
protein binding 2.01254413740256 bayes_pls_golite062009
transforming growth factor beta receptor binding 1.87074199164241 bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase binding 1.87074199164241 bayes_pls_golite062009
cell surface binding 1.71347296916502 bayes_pls_golite062009
type II transforming growth factor beta receptor binding 1.60271967659465 bayes_pls_golite062009
vascular endothelial growth factor receptor binding 1.43930353468665 bayes_pls_golite062009
cytokine activity 1.29821582644036 bayes_pls_golite062009
platelet-derived growth factor receptor binding 1.02262292046677 bayes_pls_golite062009
neurotrophin receptor binding 0.81172494974121 bayes_pls_golite062009
heparin binding 0.8114984612971 bayes_pls_golite062009
vascular endothelial growth factor receptor 2 binding 0.808551053262969 bayes_pls_golite062009
glycosaminoglycan binding 0.79853499343535 bayes_pls_golite062009
polysaccharide binding 0.539968806788969 bayes_pls_golite062009
growth factor binding 0.49508779568124 bayes_pls_golite062009
protein dimerization activity 0.426935963412231 bayes_pls_golite062009
pattern binding 0.377711019199199 bayes_pls_golite062009
hormone activity 0.344797552374249 bayes_pls_golite062009
vascular endothelial growth factor receptor 1 binding 0.250978411198471 bayes_pls_golite062009
platelet-derived growth factor binding 0.186615795527151 bayes_pls_golite062009
protein homodimerization activity 0.176088530902184 bayes_pls_golite062009
identical protein binding 0.0880365341657661 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle