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Protein Overview: mGluRA-PA, FBpp0...

General Information:
Name(s) found: FBpp0305080 [FlyBase]
mGluRA-PA / FBpp0088248 [FlyBase]
Description(s) found:
Found 30 descriptions.
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  • type=protein; loc=4:join(959056..959743,960800..961343,963393..963646,963729..963835,964174..964299,964360..964879,964932..965227,966851..967246); ID=FBpp0305080; name=mGluR-PB; parent=FBgn0019985,FBtr0332858; dbxref=REFSEQ:NP_001259076,GB_protein:AGB96566,FlyBase:FBpp0305080,FlyBase_Annotation_IDs:CG11144-PB; MD5=3022f039c15b4e0a46edf5cb1019962c; length=976; release=r5.56; species=Dmel; [FlyBase]
  • The gene metabotropic glutamate receptor is referred to in FlyBase by the symbol Dmel\mGluRA (CG11144, FBgn0019985). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 4:957468..967451. It has the cytological map location 102F1-102F3. There is experimental evidence that it has the molecular function</span>: cholesterol binding; glutamate binding. There is experimental evidence that it is involved in the biological process</span>: regulation of synaptic transmission, glutamatergic; neuromuscular junction development. 7 alleles are reported. The phenotype of these alleles is annotated with: type I bouton. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 976 amino acids

    Gene Ontology:
    Cellular Component: integral to plasma membrane [NAS]
    membrane raft [IDA]
    integral to membrane [IEA][ISS]
    plasma membrane [IDA][NAS]
    Biological Process: neuromuscular junction development [IMP]
    G-protein coupled receptor protein signaling pathway [IEA]
    metabotropic glutamate receptor signaling pathway [ISS]
    regulation of synaptic transmission, glutamatergic [IMP]
    Molecular Function: G-protein coupled receptor activity [IEA][ISS]
    cholesterol binding [IDA]
    glutamate receptor activity [ISS][NAS]
    glutamate binding [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKQKNNNGTI LVVVMVLSWS RVVDLKSPSN THTQDSVSVS LPGDIILGGL FPVHEKGEGA  60
   61 PCGPKVYNRG VQRLEAMLYA IDRVNNDPNI LPGITIGVHI LDTCSRDTYA LNQSLQFVRA 120
  121 SLNNLDTSGY ECADGSSPQL RKNASSGPVF GVIGGSYSSV SLQVANLLRL FHIPQVSPAS 180
  181 TAKTLSDKTR FDLFARTVPP DTFQSVALVD ILKNFNWSYV STIHSEGSYG EYGIEALHKE 240
  241 ATERNVCIAV AEKVPSAADD KVFDSIISKL QKKPNARGVV LFTRAEDARR ILQAAKRANL 300
  301 SQPFHWIASD GWGKQQKLLE GLEDIAEGAI TVELQSEIIA DFDRYMMQLT PETNQRNPWF 360
  361 AEYWEDTFNC VLTSLSVKPD TSNSANSTDN KIGVKAKTEC DDSYRLSEKV GYEQESKTQF 420
  421 VVDAVYAFAY ALHNLHNDRC NTQSDQTTET RKHLQSESVW YRKISTDTKS QACPDMANYD 480
  481 GKEFYNNYLL NVSFIDLAGS EVKFDRQGDG LARYDILNYQ RQENSSGYQY KVIGKWFNGL 540
  541 QLNSETVVWN KETEQPTSAC SLPCEVGMIK KQQGDTCCWI CDSCESFEYV YDEFTCKDCG 600
  601 PGLWPYADKL SCYALDIQYM KWNSLFALIP MAIAIFGIAL TSIVIVLFAK NHDTPLVRAS 660
  661 GRELSYTLLF GILVCYCNTF ALIAKPTIGS CVLQRFGIGV GFSIIYSALL TKTNRISRIF 720
  721 HSASKSAQRL KYISPQSQVV ITTSLIAIQV LITMIWMVVE PPGTRFYYPD RREVILKCKI 780
  781 QDMSFLFSQL YNMILITICT IYAIKTRKIP ENFNESKFIG FTMYTTCIIW LAFVPIYFGT 840
  841 GNSYEVQTTT LCISISLSAS VALVCLYSPK VYILVFHPDK NVRKLTMNST VYRRSAAAVA 900
  901 QGAPTSSGYS RTHAPGTSAL TGGAVGTNAS SSTLPTQNSP HLDEASAQTN VAHKTNGEFL 960
  961 PEVGERVEPI CHIVNK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..611] PSI-BLAST 89.522879 No description for 2e4uA was found.
    2 View Details [612..976] FFAS03 1.3 Rhodopsin


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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