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Protein Overview: MED26-PA, MED26-PB

General Information:
Name(s) found: MED26-PA / FBpp0088314 [FlyBase]
MED26-PB / FBpp0088313 [FlyBase]
Description(s) found:
Found 32 descriptions.
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  • The gene Mediator complex subunit 26 is referred to in FlyBase by the symbol Dmel\MED26 (CG1793, FBgn0039923). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 4:799080..809604. It has the cytological map location 102E1. Based on sequence similarity, it is predicted to have molecular function</span>: transcription factor activity; RNA polymerase II transcription mediator activity. There is experimental evidence that it is involved in the biological process</span>: phagocytosis, engulfment. 5 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
  • The gene Mediator complex subunit 26 is referred to in FlyBase by the symbol Dmel\MED26 (CG1793, FBgn0039923). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 4:799080..809604. It has the cytological map location 102E1. Based on sequence similarity, it is predicted to have molecular function</span>: transcription factor activity; RNA polymerase II transcription mediator activity. There is experimental evidence that it is involved in the biological process</span>: phagocytosis, engulfment. 5 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1483 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEA]
    mediator complex [ISS]
    Biological Process: phagocytosis, engulfment [IMP]
    transcription [IEA]
    transcription initiation from RNA polymerase II promoter [ISS]
    Molecular Function: DNA binding [IEA]
    transcription factor activity [ISS]
    protein binding [IEA]
    transcription regulator activity [IEA]
    RNA polymerase II transcription mediator activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNQIEIQELT THLSQALDQN YDVVNMDAVL CVICALEGTT ITKEQLEATR LAKYINQLRR  60
   61 RTKNEHLARR AKSLLKKWRE MVGIQQTATE NLAHPSQISS SQPALDLVKS PITSFITEPI 120
  121 APSQQIVSDL HSNIDSAEPP LSGEHTLLHP NFSNLVNSIK DSDRHENIAI TTLHTHKDRR 180
  181 HSHSIRSCHV ASPQPIVIDH SVNSVINLTD DSTVKINEAS VVIDIASDSD ENDNNGSLNP 240
  241 KKLNSIVPAP LPIPSTPSSR QRKLKKEKRS KEREGQVATN TRFGAKASDG FQQAALTTDS 300
  301 EIFSLSNSSM SSIVSGDATS SYSQNKSRLN SNELTFTGRF KAVDHLFRST ESGKHKIDEY 360
  361 SAYDSNASCS RLSPSTVDEV KKAEHLFDAQ LTNTTANQIP MSAVSIGYES NTRHEYLESD 420
  421 SPSQIPKRRG RKKGSKGVDA LIAKESSSLS QQIFFGGSTV KKVKTTKELF NEIQSRKLSV 480
  481 SMQSSASNLS NSSTNRDLPS HTTFPRQTSS CSDTSMNSPH ILETLSGSAI FASKIDDLGN 540
  541 TDSDTVTSDP SHDSNKSQEI KECTSLDSNS NSIQSLPLAN NRENLIPTNV NDITTQLMHL 600
  601 IHSLNSPLSE IEIERVYQEK IIPCTCIVIE GVQGTLGESN NSTLDEQSYN AKISLNSKDN 660
  661 LSCHNQDNYS TSQRSVNGEV IDTQPKLVKS IFDLDFDDND DPLYFIMDEI QKPIARADEL 720
  721 KNNKSDTKNI NFGASAQNAS LNIIHFNDDA QQDNSNQERG KNETQNAIPA FTVHEDPDCL 780
  781 ARQRFYIQTN KVTSFHINAL HNYYIPNING NWDSVESFTS FQSEHTIMDT MESYTVTNGA 840
  841 DVVPKYGLLT SDRIRKDLSS LKSIKPYRVK NFTSLISPFL GVAKCLPTCR RARRRFKNFV 900
  901 NSSTANDKIS NNFESLENMK TSFKNCNPLN VKIDGTTSAI YSHNENHVPM QVNTNVEQLP 960
  961 PSQSFSSNAI SYNLLKLADD KVCHDGISDK SSNTGCQGNS PYSSSSSSSY SGRKEDQHII1020
 1021 TKNLQNKNIQ LNSRKSDMKR RKRIYLENDS KKKKHYRKRI KTAVNRTFSN LHRNLYSIDS1080
 1081 ENGMKNDYKN EYGNSNNEEY AIVQRPAGDG ENCSNHIVLT IKKTPSKINS PANSMTAFSP1140
 1141 PSTSDGANLQ KSILDLRLED TNISQSITEI PQKKDLSKTD RIVHQSRSSA YRRIFRKPDK1200
 1201 SQTKFIDLDL KHLFHLKANS PCISANAKLH NKLFFPHELS RDNTSGIRER LINYSSSSSS1260
 1261 SYDDDSEVEN TSFLKKANVN KFSASNNRNL KTETETCAAT AISEFKFESD EDSILTSLGD1320
 1321 SDIDIQDEIQ VINDKVDYCN DFQNNKMLES FNSIFVDSLR TNTKNASDNM GSSAHITSLE1380
 1381 SLKPENADAI TRYCNNNNLG VNLSNELSNI SAKPLKSFDS TMKLPSLGIE HCTGIKTSSD1440
 1441 MASTNIAEKK LTRIQQFKEW HQVLQLRSYN NEPLIVLPYV LLE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..362] PSI-BLAST 15.30103 RNA polymerase II-TFIIS complex
    2 View Details [363..538] MSA 3.400996 View MSA. No confident structure predictions are available.
    3 View Details [539..777] deduced N/A No confident structure predictions are available.
    4 View Details [778..1008] deduced N/A No confident structure predictions are available.
    5 View Details [1009..1141] deduced N/A No confident structure predictions are available.
    6 View Details [1142..1370] deduced N/A No confident structure predictions are available.
    7 View Details [1371..1483] deduced N/A No confident structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle