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Protein Overview: Acf1-PA

General Information:
Name(s) found: Acf1-PA / FBpp0085204 [FlyBase]
Description(s) found:
Found 21 descriptions.
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  • The gene ATP-dependent chromatin assembly factor large subunit is referred to in FlyBase by the symbol Dmel\Acf1 (CG1966, FBgn0027620). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:27619811..27625533. It has the cytological map location 100D2. There is experimental evidence that it has the molecular function</span>: protein binding; DNA binding. There is experimental evidence for 12 unique biological process</span> terms, many of which group under: anatomical structure development; chromatin organization; cellular macromolecular complex subunit organization; organelle organization; regulation of metabolic process; organ development; chromosome organization; system development; neuron differentiation; regulation of biological process. 13 alleles are reported. The phenotype of these alleles is annotated with: S phase. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1476 amino acids

    Gene Ontology:
    Cellular Component: chromatin assembly complex [NAS]
    ACF complex [IDA][IPI]
    chromatin accessibility complex [IDA][NAS]
    [NOT]NURF complex [IDA]
    Biological Process: negative regulation of gene-specific transcription [IMP]
    epidermis development [IMP]
    nervous system development [IMP]
    regulation of transcription, DNA-dependent [IDA]
    chromatin assembly or disassembly [NAS][TAS]
    neuron development [IMP]
    nucleosome assembly [IDA]
    nucleosome mobilization [IDA][TAS]
    dendrite morphogenesis [IMP]
    muscle organ development [IMP]
    regulation of ATPase activity [IDA]
    chromatin assembly [IDA]
    nucleosome positioning [IDA]
    Molecular Function: [NOT]histone acetyltransferase activity [IDA]
    DNA binding [IDA][TAS]
    zinc ion binding [IEA]
    protein binding [IPI]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPICKREGFD LNQKEGKNET FHDNDQVFCC YITKRIFRDY EHYFRHVMVI NSTVWQCEAT  60
   61 GKENLTYEEA VKSERAARKK MEQFKQSLRA PVLLVVEHAQ QSAVNTLNMI VAKFLRKRYF 120
  121 IGEEVSVQAK KNATYTVLGV KLDKNMPEPL NGIYEDTDNL VYRLRPNKGD PSAELDLPFR 180
  181 QLRRSRMEFN LENLSMFIKS NVSRVDGLLR PKPEAYKQYV TDPGVNFSTI FIGKMPRYSP 240
  241 AKIKKPDGKK QSTLNKYIVA GEATAAKSKA KAKSDAKSLA EELERVKREK EAKLIELEKQ 300
  301 KAEKKAQLIE RVENECNLLL QKTDDLERTD QKVLPRYRQI VTLLPEHLLG DAFMMREFMH 360
  361 TYTGLLSGIE VFRQNLSFYE MTRALTAREI AGPLSDILLV LLGTVFDLQK EEEEECAVTY 420
  421 LDRAAQTQEP YWSMAQAAKS HLYAKRHFSF KVNELPLDAL TLSEVLRLHL LGSGAFVNEK 480
  481 AERWRVMYRN GYSSKEDPGL ELRLEHSHIL RILKNHSVYQ LKFKDIMLLI RCLMSQIMTY 540
  541 SGTINLIEER MEQTAKARQD LRALVVGENK RLAAVEINRK KLTQMHHLEV NGVEPEKREA 600
  601 LVEKLKKSIA ELHAQSDQQH RKHELQMLKL HSQLFNFLVY LGMDRCYRKY YVLESMPGIF 660
  661 VEHSPDSLDT CLEQPITNKS QIEIRQQSAL PKNRKDLRVY LLKLYGDDEK KTKKKAKHSL 720
  721 ENKENQEHRL NGSAEPMDVE SDSPEAPTHF ELLMCSGDKR SCIVHDSRNG QRQRWAYIYK 780
  781 AEEIDELIKA LNPNGLREYE LLQELSVLRS LIEQHAKTCP VDLLSLENET MRKKFMAAME 840
  841 SETNRKYGEA NFGLPNGTDL NEVMRLHLVD RIIQFENDIY TGDLGRLKVK DMEKWRSDLL 900
  901 GGNYDAQCKL QWGPGGKLED EAGSDNESHE THEEDDGALL GKYARKPYRD PGMYLAASAD 960
  961 TKPLPDSDDE EDQHTNAVSI PIAVHNMASA LLQVEQAIGK RFLKEPYGMK KWDPKQEALK1020
 1021 LACDSRLHQW EVSLMESTSF AQVFLHLNIL HDCIQWRRST NKSLCKVCRR GSDPEKMLLC1080
 1081 DECNAGTHMF CLKPKLRSVP PGNWYCNDCV KSLGLSNGQN EKDKKQATKK KRKFIVEEED1140
 1141 DEATDEEEEE KKDDDMTDED AEHENEKHDE DVEDDESVTS TPSSSRVNGR ILRRPRTRPT1200
 1201 SRRLTSKEIE EHAQEDVDSG DVSDDASLTA GEDTIEDESD EEKVCQKCFY DGGEIKCVQC1260
 1261 RLFFHLECVH LKRPPRTDFV CKTCKPMPQR PRRRHSNMNG DHDRDEEEPK AKRPRNSLRL1320
 1321 SIDKTARPSN GNNNNNNNNS SVNNNNHRRS GRRTNEHMPL NSAALYDLLE QIMKHKAAWP1380
 1381 FLRPVLTSEV PDYHQIIKTP MDLAKIKSKL NMGAYQLNEE LLSDIQLVFR NCDLYNVEGN1440
 1441 EIYDAGCQLE RFVIDRCRDM QLPFRPSDMN GEVKAC

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..230] deduced N/A No confident structure predictions are available.
    2 View Details [231..429] PSI-BLAST 17.09691 Heavy meromyosin subfragment
    3 View Details [430..641] PSI-BLAST 3.39794 Crystal Structure Analysis of ClpB
    4 View Details [642..872] deduced N/A No confident structure predictions are available.
    5 View Details [873..933] deduced N/A No confident structure predictions are available.
    6 View Details [934..1022] deduced N/A No confident structure predictions are available.
    7 View Details [1023..1123] PSI-BLAST 38.154902 No description for 2i13A was found.
    8 View Details [1124..1400] PSI-BLAST 5.0 Hybrid domain of integrin beta; Integrin beta A domain; Integrin beta tail domain; Integrin beta EGF-like domains
    9 View Details [1401..1476] PSI-BLAST 10.39794 No description for 2f6jA was found.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle