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Protein Overview: Med-PB

General Information:
Name(s) found: Med-PB / FBpp0085177 [FlyBase]
Description(s) found:
Found 21 descriptions.
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  • The gene Medea is referred to in FlyBase by the symbol Dmel\Med (CG1775, FBgn0011655). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:27436787..27440927. It has the cytological map location 100C7-100D1. There is experimental evidence that it has the molecular function</span>: protein binding. There is experimental evidence for 13 unique biological process</span> terms, many of which group under: anatomical structure development; regulation of developmental process; reproductive process in a multicellular organism; regulation of biological process; regionalization; stem cell differentiation; organ morphogenesis; neuron differentiation; multicellular organism reproduction; cell proliferation; positive regulation of cellular component biogenesis; dorsal/ventral axis specification. 47 alleles are reported. The phenotypes of these alleles are annotated with 28 unique terms, many of which group under: organ system; adult segment; thoracic segment; appendage segment; adult mesothoracic segment; germarium; portion of tissue; metatarsus; cell component; midgut constriction; podocyte; t-bar; nervous system; cell cycle; synapse; imaginal precursor; spiracle; neuromuscular junction; late extended germ band embryo. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 697 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IPI][TAS]
    transcription factor complex [IEA]
    cytoplasm [IDA]
    Biological Process: cell proliferation [IMP]
    imaginal disc-derived leg morphogenesis [IMP]
    negative regulation of salivary gland boundary specification [TAS]
    retinal ganglion cell axon guidance [IMP]
    transforming growth factor beta receptor signaling pathway [IGI][IMP][ISS][TAS]
    imaginal disc-derived wing morphogenesis [IMP]
    germ-line stem cell division [IMP][TAS]
    regulation of transcription, DNA-dependent [IEA][NAS]
    dorsal/ventral axis specification [IMP]
    neuron development [IMP]
    positive regulation of synaptic growth at neuromuscular junction [IMP]
    dorsal/ventral pattern formation [IMP]
    heart development [TAS]
    germ-line stem cell maintenance [IMP]
    BMP signaling pathway [TAS]
    ovarian follicle cell development [IMP]
    somatic stem cell maintenance [IMP]
    Molecular Function: DNA binding [TAS]
    transcription factor activity [IEA]
    protein binding [IPI]
    RNA polymerase II transcription factor activity [NAS]
    transforming growth factor beta receptor, common-partner cytoplasmic mediator activity [NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGGGSGACPP AHMYGAVAPQ DIIVRDMVQM PPPPSNAPTS ADACLSIVHS LMCHRQGGES  60
   61 EGFAKRAIES LVKKLKEKRD ELDSLITAIT TNGAHPSKCV TIQRTLDGRL QVAGRKGFPH 120
  121 VIYARIWRWP DLHKNELKHV KYCAFAFDLK CDSVCVNPYH YERVVSPGID LSGLSLQSGP 180
  181 SRLVKDEYSA GPLVGSMDID GNDIGTIQHH PTQMVGPGGY GYPQGPSEYA VPHGMPGMPG 240
  241 PMNPGPVMAP PPPPQQAQNP QGNGVHHTQA NSPTDPASAL AMQQQQQQQQ QQQQQQQQQQ 300
  301 QQSGGVPNGS VNAGGGAAAG GQYYGQPPPV SQMQGAGGGG TSVAPSVHAQ QNGYVSQPGS 360
  361 AGSAPVGGGG VFGTAQPTPQ QPQQPPTGVQ ANTGSAGAQA GAGGGAAGTW TGPNTLTYTQ 420
  421 SMQPPDPRSL PGGFWNSSLS GDLGSPQQTP PQQQQQQQQP RLLSRQPPPE YWCSIAYFEL 480
  481 DTQVGETFKV PSAKPNVIID GYVDPSGGNR FCLGALSNVH RTEQSERARL HIGKGVQLDL 540
  541 RGEGDVWLRC LSDNSVFVQS YYLDREAGRT PGDAVHKIYP AACIKVFDLR QCHQQMHSLA 600
  601 TNAQAAAAAQ AAAVAGVANQ QMGGGGRSMT AAAGIGVDDL RRLCILRLSF VKGWGPDYPR 660
  661 QSIKETPCWI EVHLHRALQL LDEVLHAMPI DGPRAAA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..166] PSI-BLAST 47.045757 SMAD MH1 domain
    2 View Details [167..399] PSI-BLAST 5.0 Sec24
    3 View Details [400..456] deduced N/A No confident structure predictions are available.
    4 View Details [457..697] PSI-BLAST 83.522879 CRYSTAL STRUCTURE OF THE SMAD4 TUMOR SUPPRESSOR C-TERMINAL DOMAIN


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle