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Protein Overview: FBpp0306613, Can...

General Information:
Name(s) found: FBpp0306613 [FlyBase]
CanA1-PA / FBpp0085094 [FlyBase]
Description(s) found:
Found 28 descriptions.
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  • type=protein; loc=3R:join(26865861..26866032,26867266..26867597,26867686..26867797,26868000..26868145,26868203..26868420,26868481..26868574,26868839..26868964,26869111..26869192,26869440..26869517,26869777..26869861,26869927..26870024,26871788..26872113); ID=FBpp0306613; name=CanA1-PD; parent=FBgn0010015,FBtr0334546; dbxref=FlyBase:FBpp0306613,FlyBase_Annotation_IDs:CG1455-PD,REFSEQ:NP_001247378,GB_protein:AFH06695; MD5=dda1cd5d116a8f151b8eb72e37f690e0; length=622; release=r5.56; species=Dmel; [FlyBase]
  • The gene Calcineurin A1 is referred to in FlyBase by the symbol Dmel\CanA1 (CG1455, FBgn0010015). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:26865098..26872546. It has the cytological map location 100B1. Based on sequence similarity, it is predicted to have molecular function</span>: calcium-dependent protein serine/threonine phosphatase activity; protein serine/threonine phosphatase activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: protein amino acid dephosphorylation. 6 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 622 amino acids

    Gene Ontology:
    Cellular Component: calcineurin complex [ISS][NAS]
    synaptic vesicle [NAS]
    Biological Process: vesicle-mediated transport [NAS]
    protein amino acid dephosphorylation [ISS][NAS]
    neurotransmitter secretion [NAS]
    Molecular Function: protein serine/threonine phosphatase activity [ISS][NAS]
    calcium-dependent protein serine/threonine phosphatase activity [ISS][NAS]
    hydrolase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSATSTRSSV TRKSSLSKSS SSDKSAKSSS NSSKSPTAAS GNKQKMQYTK TRERMVDDVP  60
   61 LPPTHKLTMS EVYDDPKTGK PNFDALRQHF LLEGRIEEAV ALRIITEGAA LLREEKNMID 120
  121 VEAPITVCGD IHGQFFDLVK LFEVGGPPAT TRYLFLGDYV DRGYFSIECV LYLWSLKITY 180
  181 PTTLSLLRGN HECRHLTEYF TFKQECIIKY SESIYDACME AFDCLPLAAL LNQQFLCIHG 240
  241 GLSPEIFTLD DIKTLNRFRE PPAYGPMCDL LWSDPLEDFG NEKTNEFFSH NSVRGCSYFF 300
  301 SYSACCEFLQ KNNLLSIVRA HEAQDAGYRM YRKNQVTGFP SLITIFSAPN YLDVYNNKAA 360
  361 VLKYENNVMN IRQFNCSPHP YWLPNFMDVF TWSLPFVGEK VTEMLVNILN ICSDDELVAG 420
  421 PDDELEEELR KKIVLVPANA SNNNNNNNTP SKPASMSALR KEIIRNKIRA IGKMSRVFSI 480
  481 LREESESVLQ LKGLTPTGAL PVGALSGGRD SLKEALQGLT ASSHIHSFAE AKGLDAVNER 540
  541 MPPRRPLLMS ASSSSITTVT RSSSSSSNNN NNNSNTSSTT TTKDISNTSS NDTATVTKTS 600
  601 RTTVKSATTS NVRAGFTAKK FP

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..622] PSI-BLAST 157.0 Protein phosphatase-2B (PP-2B, calcineurin A subunit)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphoprotein phosphatase activity
    		•  11.6417995308386 bayes_pls_golite062009
  • protein serine/threonine phosphatase activity
    		•  10.6440947462013 bayes_pls_golite062009
  • phosphatase activity
    		•  10.5525832502704 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  10.3702645338723 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  9.02791306892273 bayes_pls_golite062009
  • calcium-dependent protein serine/threonine phosphatase activity
    		•  7.59009048424811 bayes_pls_golite062009
  • myosin phosphatase activity
    		•  5.31703100176823 bayes_pls_golite062009
  • hydrolase activity
    		•  3.13006743434485 bayes_pls_golite062009
  • structural constituent of muscle
    		•  2.91086263632625 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.68552051869632 bayes_pls_golite062009
  • kinase activity
    		•  1.67788383575784 bayes_pls_golite062009
  • structural molecule activity
    		•  1.5850868178597 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.57807175808088 bayes_pls_golite062009
  • protein kinase activity
    		•  1.4514460578232 bayes_pls_golite062009
  • binding
    		•  1.44538582463569 bayes_pls_golite062009
  • catalytic activity
    		•  1.39852585255405 bayes_pls_golite062009
  • transferase activity
    		•  1.3407391509244 bayes_pls_golite062009
  • protein binding
    		•  1.33435965029646 bayes_pls_golite062009
  • transporter activity
    		•  1.24767072239634 bayes_pls_golite062009
  • signal transducer activity
    		•  1.08090214431427 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.08090214431427 bayes_pls_golite062009
  • calmodulin binding
    		•  0.77173071932406 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.66803085638835 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.528189469950839 bayes_pls_golite062009
  • protein transporter activity
    		•  0.10469955758282 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle