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Protein Overview: FBpp0306575, 5-H...

General Information:
Name(s) found: FBpp0306575 [FlyBase]
5-HT7-PA / FBpp0085108 [FlyBase]
Description(s) found:
Found 31 descriptions.
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  • type=protein; loc=3R:complement(26795606..26797300); ID=FBpp0306575; name=5-HT7-PB; parent=FBgn0004573,FBtr0334508; dbxref=FlyBase:FBpp0306575,FlyBase_Annotation_IDs:CG12073-PB,REFSEQ:NP_001263131,GB_protein:AGB96510; MD5=553600117b5c3c023fd1b6dc927bd269; length=564; release=r5.56; species=Dmel; [FlyBase]
  • The gene Serotonin receptor 7 is referred to in FlyBase by the symbol Dmel\5-HT7 (CG12073, FBgn0004573). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:26794864..26842569. It has the cytological map location 100B1. Based on sequence similarity, it is predicted to have molecular function</span>: G-protein coupled amine receptor activity; G-protein coupled serotonin receptor activity; serotonin receptor activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: serotonin receptor signaling pathway. 7 alleles are reported. The phenotype of these alleles is annotated with: Malpighian tubule. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 564 amino acids

    Gene Ontology:
    Cellular Component: integral to plasma membrane [NAS]
    integral to membrane [IEA][ISS]
    plasma membrane [ISS]
    Biological Process: activation of adenylate cyclase activity by serotonin receptor signaling pathway [NAS][TAS]
    serotonin receptor signaling pathway [ISS]
    Molecular Function: dopamine receptor activity [IEA]
    G-protein coupled serotonin receptor activity [ISS][NAS]
    serotonin receptor activity [ISS][TAS]
    G-protein coupled amine receptor activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALSGQDWRR HQSHRQHRNH RTQGNHQKLI STATLTLFVL FLSSWIAYAA GKATVPAPLV  60
   61 EGETESATSQ DFNSSSAFLG AIASASSTGS GSGSGSGSGS GSGSGSYGLA SMNSSPIAIV 120
  121 SYQGITSSNL GDSNTTLVPL SDTPLLLEEF AAGEFVLPPL TSIFVSIVLL IVILGTVVGN 180
  181 VLVCIAVCMV RKLRRPCNYL LVSLALSDLC VALLVMPMAL LYEVLEKWNF GPLLCDIWVS 240
  241 FDVLCCTASI LNLCAISVDR YLAITKPLEY GVKRTPRRMM LCVGIVWLAA ACISLPPLLI 300
  301 LGNEHEDEEG QPICTVCQNF AYQIYATLGS FYIPLSVMLF VYYQIFRAAR RIVLEEKRAQ 360
  361 THLQQALNGT GSPSAPQAPP LGHTELASSG NGQRHSSVGN TSLTYSTCGG LSSGGGALAG 420
  421 HGSGGGVSGS TGLLGSPHHK KLRFQLAKEK KASTTLGIIM SAFTVCWLPF FILALIRPFE 480
  481 TMHVPASLSS LFLWLGYANS LLNPIIYATL NRDFRKPFQE ILYFRCSSLN TMMRENYYQD 540
  541 QYGEPPSQRV MLGDERHGAR ESFL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..127] MSA 2.034987 View MSA. No confident structure predictions are available.
    2 View Details [128..438] PSI-BLAST 34.154902 Rhodopsin
    3 View Details [439..564] FFAS03 5.05 Rhodopsin


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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