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Protein Overview: PH4alphaNE2-PA

General Information:
Name(s) found: PH4alphaNE2-PA / FBpp0085047 [FlyBase]
Description(s) found:
Found 18 descriptions.
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  • The gene prolyl-4-hydroxylase-alpha NE2 is referred to in FlyBase by the symbol Dmel\PH4Ã?&#142;Ã?±NE2 (CG9720, FBgn0039783). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:26335805..26337936. It has the cytological map location 99F6. Based on sequence similarity, it is predicted to have molecular function</span>: procollagen-proline 4-dioxygenase activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: peptidyl-proline hydroxylation to 4-hydroxy-L-proline. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 542 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum [IEA]
    procollagen-proline 4-dioxygenase complex [IC]
    Biological Process: oxidation reduction [IEA]
    peptidyl-proline hydroxylation to 4-hydroxy-L-proline [ISS]
    Molecular Function: procollagen-proline 4-dioxygenase activity [ISS]
    L-ascorbic acid binding [IEA]
    oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [IEA]
    iron ion binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLFWRLVLLG MLYLSLSFGQ LRENNAQQRF ARSVVNMDDM LNLEDDLVSN VEKLAEALAR  60
   61 KAKTIKWGVF KMMKRRQEYK SSMEIFANPI DTFSLIRHMQ SNWLMWLLYL ETPVGQEELF 120
  121 FVDSRMPLLP KYFDFIDAAE GIRKMQATYQ MFSSDIAKGL LDGVQYNSSL KPIDCLAIGL 180
  181 HLMNNSRWYA AEQWISASIE AYDQKSSQTD MELLRGPKLA DLCRILGQVQ MKQRNHEGAL 240
  241 QAYQVALKLS PHDPEIYEEY RILEKRDLTL SDIEPIEQDK DNSHERLVLP PCCSGRCQVP 300
  301 RNLSNLYCVY NHVTSPFLQL APIKTEILSI DPFVVLLHDM ISQKESTLIR TSSKEHMLPS 360
  361 ATTDPDASDD ETQVDTYRTS KSVWYSSDFN DTTKKITERL GDATGLDMNS TEFYQVINYG 420
  421 LGGFFETHLD MLLSEKNRFN GTSDRIATTL FYLNEVRQGG GTYFPRLNLT VFPQPGSALF 480
  481 WYNLDTKGND HMGSLHTGCP VIVGSKWVMS KWINDMGQEF TRPCVESSLS SNEVLSAERL 540
  541 II

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..313] PSI-BLAST 34.0 The superhelical TPR domain of O-linked GlcNAc transferase reveals structural similarities to importin alpha.
    2 View Details [314..542] FFAS03 5.66 No description for 2hbtA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • procollagen-proline 4-dioxygenase activity
    		•  7.0422525853653 bayes_pls_golite062009
  • procollagen-proline dioxygenase activity
    		•  7.0422525853653 bayes_pls_golite062009
  • peptidyl-proline dioxygenase activity
    		•  7.0422525853653 bayes_pls_golite062009
  • peptidyl-proline 4-dioxygenase activity
    		•  7.0422525853653 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
    		•  5.01373106146099 bayes_pls_golite062009
  • binding
    		•  2.09193012129784 bayes_pls_golite062009
  • protein binding
    		•  1.52807685989528 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH, with oxygen as acceptor
    		•  0.534990536504941 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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