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Protein Overview: PH4alphaSG1-PA

General Information:
Name(s) found: PH4alphaSG1-PA / FBpp0085048 [FlyBase]
Description(s) found:
Found 20 descriptions.
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  • The gene prolyl-4-hydroxylase-alpha SG1 is referred to in FlyBase by the symbol Dmel\PH4Ã?&#142;Ã?±SG1 (CG31014, FBgn0051014). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:26329385..26331371. It has the cytological map location 99F6. Based on sequence similarity, it is predicted to have molecular function</span>: procollagen-proline 4-dioxygenase activity. There is experimental evidence that it is involved in the biological process</span>: salivary gland morphogenesis. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 540 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum [IEA]
    procollagen-proline 4-dioxygenase complex [IC]
    Biological Process: oxidation reduction [IEA]
    peptidyl-proline hydroxylation to 4-hydroxy-L-proline [ISS]
    salivary gland morphogenesis [IMP]
    Molecular Function: procollagen-proline 4-dioxygenase activity [ISS]
    L-ascorbic acid binding [IEA]
    oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [IEA]
    iron ion binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFRLSIILSL LCVFPVNGDY YSAISELERL LDVEAFIVEK FDEYLERAQQ EQENLKRFLD  60
   61 QIDEQQNDRG DLEEYFGNPI NAFITIKRLV HDWKFNVFDP VFDSSNFETY KNNLSDSLEK 120
  121 INFKGPTQED LHGATRALLR LQNMYQLNTD HLASGVLHPG EKNALGTSLS ASDCFELGKN 180
  181 LCEIKEYSYG SEWLLEARKR LHGKPLGFIS PNVSDVEILE HLSSAFNGLG NLKLAYKLNN 240
  241 EILDKKPDHE EALKNKILYE GQLARERSFA PRKQVELPQI AEKEQKESYK LYTQVCRGEL 300
  301 HQSPREQRNL RCWLYHQGVP YYRLSPFKIE QLNVDPYVAY VHEVLWDSEI DTIMEHGKGN 360
  361 MERSKVGQSE NSTTSEVRIS RNTWLWYDAN PWLSKIKQRL EDVTGLSTES AEPLQLVNYG 420
  421 IGGQYEPHFD FVEDDGQSVF SWKGNRLLTA LFYLNDVALG GATAFPFLRL AVPPVKGSLL 480
  481 IWYNLHSSTH KDFRTKHAGC PVLQGSKWIC NEWFHVGAQE FRRPCGLSSD EGKFLHLKDI 540
  541

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..270] PSI-BLAST 28.39794 The superhelical TPR domain of O-linked GlcNAc transferase reveals structural similarities to importin alpha.
    2 View Details [271..387] PSI-BLAST 4.30103 Crystal structure of the CHIP U-box E3 ubiquitin ligase
    3 View Details [388..540] PSI-BLAST 6.045757 No description for 2g1mA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • procollagen-proline 4-dioxygenase activity
    		•  7.0422525853653 bayes_pls_golite062009
  • procollagen-proline dioxygenase activity
    		•  7.0422525853653 bayes_pls_golite062009
  • peptidyl-proline dioxygenase activity
    		•  7.0422525853653 bayes_pls_golite062009
  • peptidyl-proline 4-dioxygenase activity
    		•  7.0422525853653 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
    		•  5.01373106146099 bayes_pls_golite062009
  • binding
    		•  2.09193012129784 bayes_pls_golite062009
  • protein binding
    		•  1.52807685989528 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH, with oxygen as acceptor
    		•  0.534990536504941 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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