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Protein Overview: eIF4E-6-PC, eIF4...

General Information:
Name(s) found: eIF4E-6-PC / FBpp0291678 [FlyBase]
eIF4E-6-PB / FBpp0291677 [FlyBase]
eIF4E-6-PA / FBpp0084713 [FlyBase]
Description(s) found:
Found 31 descriptions.
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  • The gene eIF4E-6 is referred to in FlyBase by the symbol Dmel\eIF4E-6 (CG1442, FBgn0039622). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:24852161..24852896. It has the cytological map location 98F5. Based on sequence similarity, it is predicted to have molecular function</span>: RNA cap binding; translation initiation factor activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: translational initiation. 7 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
  • The gene eIF4E-6 is referred to in FlyBase by the symbol Dmel\eIF4E-6 (CG1442, FBgn0039622). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:24852161..24852896. It has the cytological map location 98F5. Based on sequence similarity, it is predicted to have molecular function</span>: RNA cap binding; translation initiation factor activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: translational initiation. 7 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
  • The gene eIF4E-6 is referred to in FlyBase by the symbol Dmel\eIF4E-6 (CG1442, FBgn0039622). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:24852161..24852896. It has the cytological map location 98F5. Based on sequence similarity, it is predicted to have molecular function</span>: RNA cap binding; translation initiation factor activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: translational initiation. 7 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 173 amino acids

    Gene Ontology:
    Cellular Component: eukaryotic translation initiation factor 4F complex [ISS]
    cytoplasm [IEA]
    Biological Process: translational initiation [IEA]
    Molecular Function: translation initiation factor activity [IEA][ISS]
    RNA binding [IEA]
    RNA cap binding [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MENLRQTKES SEFKMGTSLD NNKLASLGAT NKHRLQNTWT LWGVKYDPEI SWEDMLKEID  60
   61 SFNTVEDFWN LYFRIDTPSK LNRGCDYMLF KKGIRPMWED PPNKGGGRWT YKVDKRSTAE 120
  121 LDKTWLDVLL CMIGEACDHC DQICGAFVRI RKNINKISVW TKADAGDECN EQC

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..173] PSI-BLAST 56.69897 Translation initiation factor eIF4e

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • translation initiation factor activity
    		•  5.77463400860205 bayes_pls_golite062009
  • RNA cap binding
    		•  5.36300847021001 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  4.77719689034956 bayes_pls_golite062009
  • translation regulator activity
    		•  4.73214731999202 bayes_pls_golite062009
  • binding
    		•  1.48722651678341 bayes_pls_golite062009
  • RNA binding
    		•  0.95346802328085 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.60395382190349 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle