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Protein Overview: Sce-PA

General Information:
Name(s) found: Sce-PA / FBpp0084614 [FlyBase]
Description(s) found:
Found 24 descriptions.
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  • The gene Sex combs extra is referred to in FlyBase by the symbol Dmel\Sce (CG5595, FBgn0003330). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:23506126..23507746. It has the cytological map location 98B1. There is experimental evidence that it has the molecular function</span>: protein binding. There is experimental evidence that it is involved in the biological process</span>: germarium-derived female germ-line cyst encapsulation; ovarian follicle cell stalk formation; sex comb development; multicellular organismal development; chromatin silencing; sister chromatid cohesion; neurogenesis. 8 alleles are reported. The phenotypes of these alleles are annotated with: larval abdominal segment 7; metathoracic ventral denticle belt; abdominal 4 ventral denticle belt; prothoracic ventral denticle belt; embryonic thoracic segment; mesothoracic ventral denticle belt; embryonic abdominal segment; denticle belt. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 435 amino acids

    Gene Ontology:
    Cellular Component: PRC1 complex [TAS]
    cohesin complex [IDA]
    nucleolus [IDA]
    Biological Process: sister chromatid cohesion [IMP]
    ovarian follicle cell stalk formation [IMP]
    multicellular organismal development [IDA]
    germarium-derived female germ-line cyst encapsulation [IMP]
    sex comb development [IDA]
    neurogenesis [IMP]
    chromatin silencing [IDA]
    Molecular Function: zinc ion binding [IEA]
    protein binding [IPI]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTSLDPAPNK TWELSLYELQ RKPQEVITDS TEIAVSPRSL HSELMCPICL DMLKKTMTTK  60
   61 ECLHRFCSDC IVTALRSGNK ECPTCRKKLV SKRSLRADPN FDLLISKIYP SREEYEAIQE 120
  121 KVMAKFNQTQ SQQALVNSIN EGIKLQSQNR PQRFRTKGGG GGGGGGGNGN GAANVAAPPA 180
  181 PGAPTAVGRN ASNQMHVHDT ASNDSNSNTN SIDRENRDPG HSGTSAASAI TSASNAAPSS 240
  241 SANSGASTSA TRMQVDDASN PPSVRSTPSP VPSNSSSSKP KRAMSVLTSE RSEESESDSQ 300
  301 MDCRTEGDSN IDTEGEGNGE LGINDEIELV FKPHPTEMSA DNQLIRALKE NCVRYIKTTA 360
  361 NATVDHLSKY LAMRLTLDLG ADLPEACRVL NFCIYVAPQP QQLVILNGNQ TLHQVNDKFW 420
  421 KVNKPMEMYY SWKKT

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..175] PSI-BLAST 25.09691 No description for 2cklB was found.
    2 View Details [176..357] MSA 4.416997 View MSA. No confident structure predictions are available.
    3 View Details [358..435] deduced N/A No confident structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle