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Protein Overview: HLHm7-PA

General Information:
Name(s) found: HLHm7-PA / FBpp0084334 [FlyBase]
Description(s) found:
Found 42 descriptions.
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  • The gene E(spl) region transcript m7 is referred to in FlyBase by the symbol Dmel\HLHm7 (CG8361, FBgn0002633). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:21862760..21863482. It has the cytological map location 96F10. There is experimental evidence that it has the molecular function</span>: sequence-specific DNA binding; transcription repressor activity. There is experimental evidence that it is involved in the biological process</span>: startle response; brain morphogenesis; negative regulation of transcription; dendrite morphogenesis; neuron development; locomotion involved in locomotory behavior. 24 alleles are reported. The phenotypes of these alleles are annotated with 17 unique terms, many of which group under: adult segment; peripheral nervous system; adult mesothoracic segment; nervous system; organ system; external compound sense organ; thoracic segment; integumentary plate; embryonic nervous system; multi-cell-component structure. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 186 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEA][NAS]
    Biological Process: locomotion involved in locomotory behavior [IMP]
    startle response [IMP]
    negative regulation of transcription [IDA]
    regulation of transcription, DNA-dependent [IEA]
    brain morphogenesis [IMP]
    neuron development [IMP]
    regulation of transcription [IEA]
    compound eye development [TAS]
    regulation of transcription from RNA polymerase II promoter [NAS]
    dendrite morphogenesis [IMP]
    Molecular Function: transcription factor activity [TAS]
    specific RNA polymerase II transcription factor activity [NAS]
    sequence-specific DNA binding [IDA]
    transcription repressor activity [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATKYEMSKT YQYRKVMKPL LERKRRARIN KCLDELKDLM AECVAQTGDA KFEKADILEV  60
   61 TVQHLRKLKE SKKHVPANPE QSFRAGYIRA ANEVSRALAS LPRVDVAFGT TLMTHLGMRL 120
  121 NQLEQPMEQP QAVNTPLSIV CGSSSSSSTY SSASSCSSIS PVSSGYASDN ESLLQISSPG 180
  181 QVWRPW

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..121] PSI-BLAST 12.39794 Myc prot-oncogene protein
    2 View Details [122..186] deduced N/A No confident structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle